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11. |
Perinephritis hypertension inMacaca fascicularis(cynomolgus monkey)studies of the renin–angiotensin–aldosterone axis and renal hemodynamic function |
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Journal of Hypertension,
Volume 7,
Issue 9,
1989,
Page 763-763
Jack DeForrest,
Robert Scalese,
Robert Oehl,
Thomas Waldron,
Susan Mitch,
Russell Brittain,
Charles Free,
Magdi Asaad,
Dennis Burkett,
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摘要:
The purpose of the present study was to characterize the etiology of bilateral perinephritis hypertension in the non-human primate. Hypertension was induced in female cynomolgus (Macaca fascicularis) monkeys by wrapping both kidneys under sterile surgical procedures. Mean arterial pressure (MAP), plasma renin activity (PRA), plasma aldosterone concentration (ALDO), para-aminohippurate (PAH) clearance, glomerular filtration rate (GFR), urine volume, and sodium and potassium excretion were measured before and weekly after induction of the hypertension. MAP increased progressively from 108 ± 1 to 135 ± 4mmHg during the first 6 weeks thereafter, MAP remained at this elevated level. PRA was elevated two- to fivefold for up to 10 weeks after the hypertension and ALDO was elevated during 1 (139%), 4 (60%), 6 (196%), 8 (249%) and 10 (148%) weeks of the hypertension. PAH clearance and GFR were significantly reduced during week 1 of the hypertension, but returned to control values by week 2. Urine volume was increased significantly during the first week of the hypertension, while sodium and potassium excretion were not changed. Captopril (15 μmol/kg, intravenously) normalized the blood pressure regardless of the severity or duration of the disease. Additionally, captopril lowered ALDO and increased PRA. It is concluded that bilateral perinephritis hypertension in the monkey is dependent on increased activity of the renin–angiotensin–aldosterone axis.
ISSN:0263-6352
出版商:OVID
年代:1989
数据来源: OVID
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12. |
Comparison of parameters for assessing blood pressure and heart rate variability from non‐invsasive twenty‐four‐hour blood pressure monitoring |
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Journal of Hypertension,
Volume 7,
Issue 9,
1989,
Page -
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PDF (982KB)
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ISSN:0263-6352
出版商:OVID
年代:1989
数据来源: OVID
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