ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Systemic haemodynamics, plasma catecholamine levels and diurnal variation of arterial pressure were studied in a 20-year-old patient with hypertension during Guillain Barre syndrome after complete resolution of the illness. Transient arterial hypertension during the course of Guillain Barre syndrome is characterized by an increased total peripheral resistance associated with elevated circulating norepinephrine levels, suggesting an over-activity of the sympathetic nervous system as the underlying mechanism of the elevated blood pressure.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Fifty-four children aged 10-15 years were studied. Twenty-two children had mothers who had sustained hypertension after a hypertensive pregnancy (HT) and 17 had normotensive mothers who had previously had a hypertensive pregnancy (NT). A control group consisted of 15 children with normotensive mothers (C). Blood pressure was significantly higher in the HT group in comparison with the C group (P <0.01). Erythrocyte sodium (Na+) and potassium (K+) concentrations were similar in all groups and not related to blood pressure. The Na+K+ATPase activity in erythrocyte membranes was lower in the- HT group than in the NT group (P<0.02), but not significantly different from the C group. There was no statistically significant correlation between Na+K+ATPase activity and blood pressure. blood pressure.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Electrolytic lesions of the A1 noradrenaline cells in the caudal ventrolateral medulla cause transient hypertension and bradycardia in the conscious rat, as previously described in the rabbit. The lesions produced 100-fold increases in plasma arginine vasopressin, 40-fold increases in plasma adrenaline and fourfold increases in plasma noradrenaline levels. Absence of circulating vasopressin [homozygous diabetes insipidus rats (Dl)] or circulating adrenaline (adrenalectomized rats) did not affect A1 hypertension, but sympathectomy with systemic 6-hydroxydopamine (6-OHDA) significantly attenuated A1 hypertension. A factorial experiment was performed to assess the relative contributions of these three peripheral effector mechanisms in a quantitative manner, with combined deficiencies of any two or of all three of these effector systems. Results suggest A1 hypertension in the rat to be primarily mediated through increased sympatho-adrenal activity. The largest component of hypertension (66%) results from increased sympathetic vasoconstrictor nerve activity, and a smaller part (34%) reflects the action of circulating adrenaline. Increases in vasopressin levels do not contribute to A1 hypertension, although vasopressin makes a major contribution to A1 lesion bradycardia.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]iis associated with high blood pressure, we measured [Ca2+]iin the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i(thrombin, adenosine diphosphate, serotonin and ionomycin). Despite clear-cut changes in [Ca2+]iduring these manipulations, there were no differences between the SHR and WKY rats in baseline levels of [Ca2+]ior in the kinetics of changes in [Ca2+]i. These results do not support the hypothesis that high levels of [Ca2+]iat rest or abnormal kinetics of changes in [Ca2+]iplay a pathophysiological role in the hypertension of SHR.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Male Dahl-S rats were randomly assigned to either normal chow (NC) or high-salt (HS) diets to induce hypertension. Animals were further subdivided into trained (NCT, HST) and untrained (NCN, HSN) groups. Trained groups were exercised on a rodent treadmill 5 days per week for 12 weeks at a constant workload of 26.4 m/min, 5% grade, while duration progressed from 7.5 to 115 min/day.Arterial blood pressure was measured under anaesthesia by direct catheterization of femoral arteries after 4 and 8 weeks, and terminally via the carotid artery. Training resulted in significantly lower systolic and diastolic blood pressure in trained groups compared with untrained. The trained animals also had significantly lower body weights. Analysis of regressed organ weights adjusted for differences in final body weight revealed that the NCT animals had heavier hearts and kidneys than the NCN animals. The HST animals had heavier hearts and lighter kidneys than the HSN animals.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Cardiovascular and neuroendocrine reactivity during arithmetic task performance were studied in 24 patients with borderline hypertension and normotensive controls. Personal control (self-paced versus externally paced performance) resulted in an attenuated blood pressure (BP) response to task performance in normotensives but not in borderline hypertensives. In response to self-paced work, systolic blood pressure (SBP) reactivity was significantly greater in borderline hypertensives, but the heart rate (HR) reactivity was similar in borderline hypertensives and normotensives under the different pacing conditions. Task difficulty (pace variation during external pacing) did not differentially affect reactivity in borderline hypertensives and normotensives. Venous plasma noradrenaline and adrenaline were unaffected by task performance. At rest after the task performance plasma noradrenaline was elevated in both normotensives and borderline hypertensives. The latter group also showed a persistent elevation of diastolic blood pressure after task performance, suggesting a prolonged vasoconstrictor response.The present findings indicate that, in terms of circulatory responses, borderline hypertensives may profit less than normotensives from personal control over environmental demands.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

To determine whether there is a change in the sensitivity of the osmotic control of vasopressin release in deoxycorticosterone (DOC)-salt hypertension, experiments were performed in unilaterally nephrectomized rats that were either normotensive or were made hypertensive with DOC and given 1 % saline to drink. After 3 weeks of treatment, 2.5 mol/l NaCI was infused i.v. into conscious normotensive and hypertensive rats. Increases in both plasma osmolality and plasma vasopressin concentration were similar throughout the course of this infusion in the two groups of rats. Hypertonic saline infusion increased the mean arterial blood pressure in the two groups of rats, but this increase was partially attenuated by the i.v. injection of a vasopressin pressor antagonist. In conclusion, vasopressin release in response to osmotic stimulation was similar in normotensive and hypertensive rats. The pressor response to hypertonic saline in both groups of rats could be partially attributed to the increased plasma vasopressin concentration.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

It has been suggested that alterations in cell membrane proteins may play a role in changes of erythrocyte membrane structure and function in hypertension. In order to characterize the structure of membrane proteins of erythrocytes from spontaneously hypertensive rats (SHR) the spin-label technique with a maleimide spin-label was used. A significant difference was observed in the characteristic electron-spin resonance (e.s.r.) spectrum of the label between samples from normotensive rats and SHR. The difference was eliminated and the spectrum significantly changed after treatment of the labelled membrane with EDTA followed by washing out the EDTA extracts, whereas the same treatment with EDTA without the following washing had no effect on the e.s.r. spectrum. It is concluded that the EDTA extracts different substances in the different rat groups. The spin-label technique is a useful method for distinguishing cell membrane properties in SHR and normotensive rats.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

We studied the effects of training by forced swimming on plasma lipid and lipoprotein concentrations in the Lyon genetically hypertensive rats (LH), its normotensive (LN) and low blood pressure (LL) controls. Training was carried out 5 days a week for 5 weeks. The duration of daily training sessions was increased 15 min per day, from 2 to 6 h/day. Following training low density lipoprotein-cholesterol (LDL-C) was significantly lower ( P <0.01) in LL, and the very low density lipoprotein (VLDL-C) was also lower in LN (P We studied the effects of training by forced swimming on plasma lipid and lipoprotein concentrations in the Lyon genetically hypertensive rats (LH), its normotensive (LN) and low blood pressure (LL) controls. Training was carried out 5 days a week for 5 weeks. The duration of daily training sessions was increased 15 min per day, from 2 to 6 h/day. Following training low density lipoprotein-cholesterol (LDL-C) was significantly lower ( P <0.01) in LL, and the very low density lipoprotein (VLDL-C) was also lower in LN (P We studied the effects of training by forced swimming on plasma lipid and lipoprotein concentrations in the Lyon genetically hypertensive rats (LH), its normotensive (LN) and low blood pressure (LL) controls. Training was carried out 5 days a week for 5 weeks. The duration of daily training sessions was increased 15 min per day, from 2 to 6 h/day. Following training low density lipoprotein-cholesterol (LDL-C) was significantly lower ( P < 0.01) in LL, and the very low density lipoprotein (VLDL-C) was also lower in LN (P<0.01) and LH (P < 0.05) rats compared with their sedentary controls. High density lipoprotein-cholesterol (HDL-C) was not significantly increased after training in all strains. Compared with controls, plasma total cholesterol, plasma triglycerides and phospholipids were not modified by training. The reduction of LDL-C, VLDL-C as well as the increase of the HDL-C:VLDL-C ratio suggest a beneficial effect of training on atherosclerosis and perhaps coronary heart disease risk. 0.01) and LH (P <0.05) rats compared with their sedentary controls. High density lipoprotein-cholesterol (HDL-C) was not significantly increased after training in all strains. Compared with controls, plasma total cholesterol, plasma triglycerides and phospholipids were not modified by training. The reduction of LDL-C, VLDL-C as well as the increase of the HDL-C:VLDL-C ratio suggest a beneficial effect of training on atherosclerosis and perhaps coronary heart disease risk. 0.01) and LH (P < 0.05) rats compared with their sedentary controls. High density lipoprotein-cholesterol (HDL-C) was not significantly increased after training in all strains. Compared with controls, plasma total cholesterol, plasma triglycerides and phospholipids were not modified by training. The reduction of LDL-C, VLDL-C as well as the increase of the HDL-C:VLDL-C ratio suggest a beneficial effect of training on atherosclerosis and perhaps coronary heart disease risk.

ISSN:0263-6352    

出版商:OVID    

年代:1986

数据来源: OVID