摘要:

Discoloration, pigmentation and even caries-like lesions have been reported in teeth subsequent to per oral administration of antibiotics. The present in vitro study examines the possible medicament/tooth reaction by exposing plane, polished enamel surfaces to aqueous solutions or oily suspensions of/various commonly used penicillin compounds, or to solutions of tetracycline sodium.The teeth were examined by visual inspection, microhardiness tests, scanning electron microscopy and microradiography. pH and |Ca2+of the test solutions were analyzed by potentiometry. Surface or subsurface lesions and a dec-lino in mierohardness were found in (most) enamel specimens exposed to aqueous solutions of the medicaments. Similar changes were found in test specimens immersed in deionized water, while saliva, oily suspensions of the medicaments and aqueous solutions made from ordinary Ca-peniciilin had no adverse effect on the enamel. The most serious destruction was seen in enamel specimens submerged in watery solutions made from effervescent (citrate-containing) (a-pcnicillin, or from tetracycline. A slight deeline in pH was observed in the aqueous solutions during the experiment. The calcium ion concentration did not increase parallel to enamel destruction.

ISSN:0001-6357    

DOI:10.3109/00016358209024079

出版商:Taylor&Francis    

年代:1982

数据来源: Taylor

摘要:

The effect of the major phenytoin metabolite 5-(parahydroxyphenyl)-5-phenyl-hydantoin (p-HPPH) was studied on cultures on human fibroblast-like cells grown out from explanted gingival biopsies. The explants were taken from children undergoing phenytoin medication. The results showed that the number of cells per culture decreased whereas the protein and DNA- contents remained relatively unaffected. This effect was most pronounced at the concentrations of 0.20 /μg/ml p-HPPH. The results indicate that the metabolite interfere with cell division without affecting protein or DNA synthesis.

ISSN:0001-6357    

DOI:10.3109/00016358209024080

出版商:Taylor&Francis    

年代:1982

数据来源: Taylor

摘要:

The present summary and the following papers (I-VIII) are submitted in partial fulfillment of the requirements for the degree of Doctor Philosophiae at the University of Oslo.I. Composition of dental resin and composite materials. Acta Odontol. Scand. 1981, 39, 133–146Co-author: I.J. SjøvikII. Remaining methacrylate groups in composite restorative materials. Acta Odontol. Scand. 1978, 36, 75–87Co-author: S.A. SvendsenIII. Conversion in different depths of ultraviolet and visible light activated composite materials. Acta Odontol. Scand. 1982. 40, 179–192 Co-author: H.øysædIV. Compressive creep of light cured resin based restorative materials. Acta Odontol. Scand. 1982. 40, 319–324Co-author: H.øysædV. Flexural properties of denture base polymers. J. Prosthet. Dent. 1980, 43. 95–104Co-author: S.A. SvendsenVI. Compressive creep of denture base polymers. Acta Odontol. Scand. 1980, 38, 169–177Co-author: S. EspevikVII. Conversion in denture base polymers. J. Biomed Mater. Res. In press Co-author: H.øysædVIII. Release of formaldehyde from denture base polymers. Acta Odontol. Scand. 1980, 38, 17–27In this summary these papers will be referred to as Papers I-VIII. Other literature cited will be referred to in the conventional manner.

ISSN:0001-6357    

DOI:10.3109/00016358209024081

出版商:Taylor&Francis    

年代:1982

数据来源: Taylor

ISSN:0001-6357    

DOI:10.3109/00016358209024082

出版商:Taylor&Francis    

年代:1982

数据来源: Taylor