摘要:

When red cell mean corpuscular volume (MCV) is determined by use of the Coulter counter, the blood sample is first diluted in a solution with fixed osmolality (Isoton). Therefore we studied the interference of blood osmolality with MCV measured by this method. In 14 patients with hyposmolality, the correction of osmolality was accompanied by an increase in MCV of 4.7% (p < 0.001) and a decrease in mean corpuscular hemoglobin concentration (MCHC) of 4.8% (p < 0.001). In 9 patients with hyperosmolality the decrease in MCV was of 5% (p < 0.001) and the rise in MCHC of 4% (p < 0.001) after osmolality correction. Before correction of hyposmolality, 1 patient had false microcytosis and 3 had masked macrocytosis. In the hypertonic group 3 patients had initially false macrocytosis. Red blood cells (RBC) from hypotonic patients probably shrink when they are acutely placed in the Isoton which is a hypertonic solution (330 mosm/kg H2O). Conversely RBC from patients with severe hyperosmolality swell in the same conditions. The patients osmolality must be considered to interpret the MCV measured by the Coulter counter correctly, as a 10-mosm/kg H2O change in serum osmolality is responsible for an artefactual change in MCV of 1 f1.

ISSN:0001-5792    

DOI:10.1159/000207026

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

40 patients, 15 females and 25 males, with biopsy-proven non-Hodgkin’s lymphoma within the age range of 2–16 years were included in this study. The mean serum zinc level in 38 untreated patients was 78.95 ± 18.80 μg% and significantly lower than in controls (p < 0.001). The mean serum copper level in 40 untreated patients was 205.32 ± 49.44 μg% and significantly higher than in controls (p < 0.001). The mean copper/zinc ratio in these patients was 2.75 and was found to be significantly higher than in controls (p < 0.01). Copper levels were lower during remission (p < 0.05). Our data indicate that serum copper levels and the copper/zinc ratio might be indicators for disease activity in children with non-Hodgkin’s

ISSN:0001-5792    

DOI:10.1159/000207027

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207028

出版商:S. Karger AG    

年代:1982

数据来源: Karger