摘要:

In 45 splenectomized individuals without malignancies, residual splenic tissue was detected by 99mTc-scanning using reinjection of labelled heat-damaged autologous erythrocytes. The angiotensin-converting enzyme in serum (SACE) and the blood monocyte count were measured in order to demonstrate an eventual association between these parameters as well as the influence of residual splenic tissue. In 20 patients with detectable spleen tissue SACE was normal (26.2 ± 4.4 U/ml), but in 25 patients without residual spleen tissue SACE was slightly elevated (28.7 ± 6.4 U/ml; p 36.8 U/ml) as found in sarcoidosis but no signs of this disease could be demonstrated. It is concluded that splenectomy must be taken into account when the significance of raised SACE is evaluated. It may be suggested that the spleen exerts an effect on the metabolism of SACE or on the ACE-producing cells in the organi

ISSN:0001-5792    

DOI:10.1159/000207040

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Two rare cases of aplastic anemia after prolonged ingestion of indomethacin are described. One patient recovered spontaneously within several weeks following discontinuation of the drug while the second one died. The aplastic anemia may be related to the inhibitory effect of indomethacin on prostaglandins and cyclic nucleotides which have a regulatory role in erythropoiesis and myelopoiesis.

ISSN:0001-5792    

DOI:10.1159/000207041

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207042

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207043

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207044

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207045

出版商:S. Karger AG    

年代:1982

数据来源: Karger