摘要:

Non-T, non-B acute lymphoblastic leukemia (ALL) in children can be further subdivided into common, null/undifferentiated and pre-B ALL. The overall labelling indices (LI) showed comparable values for these 3 subtypes of ALL. By sequential immunological, cytochemical and cytokinetic studies on single bone marrow cells, combined with morphological evaluation, blast cells could be attributed to the compartments of E-Ia+sIgM- and E-Ia-sIgM- cells, in pre-B/B ALL also to the compartment of E-Ia+sIgM+ cells. In all 30 patients investigated, the LI of Ia+ blast cells was higher than the LI of la- blast cells (p < 0.001). However, no correlation between the percentage of Ia+ 0.1).

ISSN:0001-5792    

DOI:10.1159/000206347

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Capping with concanavalin A (ConA) and monoclonal anti-HLA-ABC backbone was studied in childhood acute lymphoblastic leukemia (ALL). Capping with ConA and HLA gave quite different results, both in common ALL and T-ALL. With ConA most cases capped poorly, comparable to results described in chronic lymphatic leukemia and lymphoma, but in several cases capping was comparable to that of normal lymphocytes. In HLA capping T-ALL cells capped better than common ALL cells. HLA capping of T-ALL cells is comparable to that of normal lymphocytes. HLA capping results in handmirror cell formation giving support to the hypothesis that capping and motility are associated events.

ISSN:0001-5792    

DOI:10.1159/000206348

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The 4th case of plasma cell neoplasm associated with a hypereosinophilic syndrome is described and compared with the previous reports. Hypereosinophilia in the present patient displayed some borderline traits with eosinophilic leukemia. Myeloproliferative disorders of the eosinophilic line often present as a precancerous state, but sometimes they seem to acquire malignant independence. In our patient the occurrence of a plasmocytoma with a dramatic course leads to suspect an underlying complex genetic aberration.

ISSN:0001-5792    

DOI:10.1159/000206349

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A case is reported of idiopathic hypereosinophilic syndrome involving many organs and systems and with a wide range of clinical findings: hematologic, cardiovascular, skin, pulmonary, spleen, liver, and gastrointestinal. Mortality in such patients is very high, but aggressive medical treatment (vincristine 2 mg/week for 5 weeks) produced a significant clinical benefit and considerably improved our patient’s prognosi

ISSN:0001-5792    

DOI:10.1159/000206350

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A patient with polycythemia vera showed marked elliptocytosis in the peripheral blood, 2 years after the diagnosis was established. 4 years later on, the patient developed myelofibrosis. The significance of elliptocytosis, which appears during the course of polycythemia vera, as an early indicator for the development of myelofibrosis is discussed.

ISSN:0001-5792    

DOI:10.1159/000206351

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A family with hereditary spherocytosis is described in which 3 sisters had haemolytic episodes during six pregnancies. None was treated with splenectomy and each pregnancy has resulted in the birth of mature live infants. Other members of the family were asymptomatic. When not pregnant, the 3 sisters were also asymptomatic. The spectrum of clinical and haematological features in hereditary spherocytosis is discussed. In patients presenting with hereditary spherocytosis and haemolysis during pregnancy, the necessity for splenectomy is assessed.

ISSN:0001-5792    

DOI:10.1159/000206352

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

In this study we have correlated the presence/absence of rare red blood cells with HbH inclusions with the α-globin genotype in a group of Sardinian α-thalassemia carriers, whose genotype have been defined by α-globin gene mapping. We found that the majority of the carriers investigated, including those with the deletion of a single or two α-globin genes and those with non-deletion lesions, have rare red blood cells with inclusions, with no significant difference in the frequency of positive finding related to the α-globin geno

ISSN:0001-5792    

DOI:10.1159/000206353

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-chromosomal-linked abnormality often associated with hemoiytic anemia. The G6PD variants obtained from 2 unrelated males, one associated with enzyme deficiency and history of hemoiytic jaundice, and the other associated with enzyme deficiency but no hemoiytic problems, were examined. Although the 2 subjects have no known consanguinity, the two enzymes could not be distinguished from each other in respect to their electrophoretic mobilities and kinetic properties, both exhibiting slower than normal anodal electrophoretic mobility, lower Km for G6P and NADP and higher rate of utilization of 2-deoxy-G6P and deamino-NADP. An unique double-banded pattern was observed in starch gel electrophoresis at pH 7.0 and pH 8.6. The variant is distinguished from all reported Gd variants, and it is designated Gd (-) Santamaria.

ISSN:0001-5792    

DOI:10.1159/000206354

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

A new case of refractory anemia with excess of blasts (RAEB) with acquired Hemoglobin H disease (HbH) evolving into acute nonlymphoid leukemia (ANLL) is reported. In this patient, both family and personal history were negative for alpha thalassemia. At time of diagnosis of RAEB, ‘golf ball’ erythrocytic inclusions, typical of HbH, were found. The cellulose acetate electrophoresis (pH 8.9) revealed a fast moving band, corresponding to HbH. An evolution into ANLL, Mi subtype, 25 months later, has been documen

ISSN:0001-5792    

DOI:10.1159/000206355

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

An unusual case of a 61-year-old woman with Burkitt-like acute lymphoblastic leukemia (ALL) is presented. The disease was confined to peripheral blood and bone marrow. Clinical features and diagnostic criteria as reviewed from the literature are described. Burkitt-like ALL seems to be a separate entity in the spectrum of B-cell diseases.

ISSN:0001-5792    

DOI:10.1159/000206356

出版商:S. Karger AG    

年代:1984

数据来源: Karger