摘要:

89 patients with acute leukemia were studied for the frequencies of HLA-A and HLA-B antigens. In this series, the frequency of the antigen A2 was increased in children with acute lymphoblastic leukemia and that of B12 in adults with acute lymphoblastic leukemia. No precise antigen was associated with acute myeloblastic leukemia at presentation, but survival analysis showed that patients positive for the antigen(s) A2 and/or B12 did significantly better in terms of mean survival. Mechanisms by which HLA antigens may interact with the established disease and with the treatment are discussed.

ISSN:0001-5792    

DOI:10.1159/000207154

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Of 46 adult patients with active leukaemia whose white cells were examined using a Hemalog D automated differential leucocyte counter, 45 showed abnormalities indicative of their disease, and the odd one out would not have been missed due to associated thrombocytopenia. Sequential studies while on chemotherapy allowed rapid and accurate neutrophil counts to be performed even in the presence of profound leucopenia and the re-emergence of blast cells in some cases was detected 2–3 weeks earlier than by microscopy. These findings indicate that the Hemalog D is reliable in the detection and can be useful in the follow-up of patients with leukaemi

ISSN:0001-5792    

DOI:10.1159/000207155

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Daily urinary colony-stimulating factor (CSF) output was tested in 16 patients with chronic myeloid leukemia, 12 of which were in stable phase and 4 in blast crisis of the disease. The CSF of stable-phase patients varied within normal range, while all patients in blast crisis had values lower than normal. Also the number of CFUC ranged within normal values in stable-phase patients, while no colony growth was detectable in blast-crisis patients. Sequential studies (28 or 11 months) of 2 patients revealed an inverse relation between daily urinary CSF and presence of peripheral immature or blast cells in the patient in stable or blast phase, respectively.

ISSN:0001-5792    

DOI:10.1159/000207156

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In a retrospective study 37 patients who fitted into the clinical spectrum of myelodysplastic syndrome were reviewed. Special attention was paid to the influence of monocyte count, degree of blastic infiltration and ring sideroblasts and on the clinical presentation and the course of the disease. Monocyte count clearly distinguishes between two groups of patients with different haematological profile and clinical course. The patients with monocytosis frequently changed to acute myeloid leukaemia and had shorter survival rates compared with those without monocytosis. The degree of blastic infiltration does not affect the haematological presentation and the frequency of acute leukaemia evolution. However, increased blastic infiltration is associated with shorter survival. Patients with ringed sideroblasts presented with profound anaemia but the clinical course of the disease did not differ from the remainder.

ISSN:0001-5792    

DOI:10.1159/000207157

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Plasma cell acid phosphatase has been studied in 51 patients, 30 of whom were affected with multiple myeloma (MM) and 21 with nonmyelomatous monoclonal immunoglobulinemias (NMMI). Scoring of results displayed a highly significant difference between the median of the MM and NMMI group (343 vs. 204). The use of plasma cell acid phosphatase as a further criterion in the differential diagnosis of monoclonal immunoglobulinemiasis emphasized.

ISSN:0001-5792    

DOI:10.1159/000207158

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The components of the peripheral white blood cells (WBC) were determined before and after 10 min of submaximal ergometric work in two groups of subjects: 34 healthy Yemenite Jews with benign familial leukopenia (BFL) and 34 healthy Yemenite Jews without BFL. The mean ± SEM of the increase in the peripheral WBC following the effort in the control group was 2,606 ± 1,272 cells/mm3, due to the relative rise in the neutrophils, eosinophils, monocytes and lymphocytes. The identical ergometric work, performed by BFL subjects, brought about a significantly lower increase (700 ± 865 cells/ mm3) in the peripheral WBC, the majority of which were lymphocytes. It seems that subjects with this form of BFL lack granulocytes in the marginal po

ISSN:0001-5792    

DOI:10.1159/000207159

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Guinea pig bone marrow basophils were cultivated in vitro and morphological observations were made by light and electron microscopy. Maturation of basophils in vitro is supported by electron microscopic evidence for the development of a prominent Golgi zone with granule formation, nuclear chromatin changes, and specific periodicity of the intragranular matrix. Histochemical staining distinguishes these cells from other granulocytes, and mitotic basophils are recognizable on light microscopy. These methods allow more detailed study of the orderly growth and development of the basophil in a system where basophilopoiesis is actively taking place.

ISSN:0001-5792    

DOI:10.1159/000207160

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Neutrophil peroxidase activity was determined before delivery in 46 pregnant women. 36 of these women were also tested on the 1st day and 30 on the 3rd day after delivery. A significant increase in the average values of neutrophil peroxidase activity was found in all parturients as compared with the controls. The highest peroxidase activity was observed before parturition. The possible mechanism of these changes is discussed.

ISSN:0001-5792    

DOI:10.1159/000207161

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The cytostatic effects of Adriamycin® on PHA-stimulated lymphocyte incubates are inhibited by the simultaneous administration of heparin. Simultaneous administration of heparin, therefore, might also interfere with the tumoricidal effect of Adriamycin® in patients receiving antitumor therap

ISSN:0001-5792    

DOI:10.1159/000207162

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Acute lymphoblastic leukaemia, defined by immunological markers as a non-T, non-B, which occurred in a patient with breast cancer 2 years after the end of radiotherapy and CMF adjuvant chemotherapy, is reported.

ISSN:0001-5792    

DOI:10.1159/000207163

出版商:S. Karger AG    

年代:1981

数据来源: Karger