摘要:

Serum muramidase values were greatly increased in all patients with monocytic leukemia, moderately elevated in chronic myelocytic leukemia, and only slightly increased in acute myelocytic leukemia. Serial estimations in patients with monocytic leukemia disclosed a sharp rise in urinary muramidase levels at the initial stages of many patients, while the change in serum muramidase levels was less marked. In remission, serum muramidase returned to normal and muramidasuria disappeared. When relapse developed, serum and urinary muramidase increased to lower levels than those at the initial maximum ones. Mature monocytes were demonstrated to contain a greater amount of muramidase than those of immature monocytes.

ISSN:0001-5792    

DOI:10.1159/000208584

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Serum immunoglobulin (IgG, IgA, IgM) levels have been determined in 22 splenectomized and 50 nonsplenectomized patients with β-thalassaemia major. Compared with 29 control subjects, all 3 immunoglobulins were statistically increased in the two thalassaemic groups. Splenectomized pa tients had higher levels of IgG and IgA, while IgM levels were found almost the same in both groups

ISSN:0001-5792    

DOI:10.1159/000208585

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The sequence of changes in the CFU content of murine bone marrow has been studied during the brief units period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment

ISSN:0001-5792    

DOI:10.1159/000208586

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Administration of phytohemagglutinin to protein-fasted and polycythemic mice results in a striking increase of spleen response to erythropoietin. An opposite ef- s feet was found in bone marrow. In transplant experiments, treatment of prospective cells donors with phytohemagglutinin produces a substantial increase of the cloning efficiency of the spleen cells with little if any effect on bone marrow cells. Results of this study also demonstrate a good correlation between the time course of cytomorphological changes induced by phytohemagglutinin on spleen lymphocytes and increase of hemopoietic stem cell concentration in this organ.

ISSN:0001-5792    

DOI:10.1159/000208587

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The influence of esterases and antiproteases on lymphocytes cultures has been investigated. Phytohaemagglutinin (PHA) and certain PHA fractions exhibited antiprotease activity. Some plant- and animal-antiproteases showed growth promoting activity in stimulated lymphocyte cultures, an effect which could be reduced considerably by incubation with trypsin. Cell homogenates and cell-free supernatants from stimulated lymphocyte cultures contained esterase activity. There is some evidence that these esterases are bound to antiproteases, a process which might be necessary for optimal lymphocyte growth.

ISSN:0001-5792    

DOI:10.1159/000208588

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

In a thalassaemic female carrying a 46, XX/46, XXqi mosaic, the occurrence of acute myeloblastic leukaemia was observed. Karyotype analysis of several bone marrow aspirates disclosed, besides both normal metaphases and metaphases containing the isochromosome, a line characterised by a supernumerary chromosome in the C group (C trisomy). A clonal proliferation of the leukaemic line from normal precursors was suggested since no cells carrying the isochromosome and the C trisomy together were found. In the course of the disease a remarkable plasma-cellular proliferation brought about a hyperglobulinaemia of monoclonal aspect (IgG, λ-type). Since the chromosomal analysis demonstrated that the presence of a C trisomy might also be present in the plasma cells, a close proliferative connection has been put forward for the stem cells differentiating along both the granulocytic and the plasmacytic line

ISSN:0001-5792    

DOI:10.1159/000208589

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The case is reported of a 25-year-old male patient who died of an acute blastocytosis after suffering for 4 years from osteomyelosclerosis. Cytochemical examination of the pathological blood cells revealed a pattern differing from all closely defined forms of haematoblastosis with immature cells, so that it was not possible to ascribe the blastocytes to a particular cell series. The possibility is discussed of their being a genetically non-homogeneous cell population, made up of undifferentiated white and red forms.

ISSN:0001-5792    

DOI:10.1159/000208590

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208591

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208592

出版商:S. Karger AG    

年代:1971

数据来源: Karger