摘要:

The uptake of serum-bound 57Co-B12 by freshly aspirated human bone marrow cells is an active, calcium-dependent process requiring the presence of cellular respiration, oxidative phosphorylation and free sulphydryl groups. In contrast, serum-mediated uptake of 57Co-B12 by reticulocytes and erythrocytes has been reported to be an energy-independent, surface-adsorption phenomenon. Bone marrow cells also take up 57Co-B12 in the absence of serum. Such uptake is dependent on cellular respiration but not on calcium ions or free sulphydryl groups. The average value for the uptake of serum-bound 57Co-B12 by vitamin B12-deficient bone marrow cells was 2.7 times greater than that for normoblastic marrow cells.

ISSN:0001-5792    

DOI:10.1159/000208386

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Using blood which was anticoagulated with heparin the Heinz body susceptibility against acetyln phenylhydrazine of adult donor erythrocytes increased only slightly in the circulation of newborn infants within 30 h after exchange transfusion. The high susceptibility of the donor erythrocytes found by Kleihauer et al. using ACD for anticoagulation 12 h after exchange transfusion might be due to the effect of Ca++ given during exchange transfusion. During in vitro incubations, the addition of Ca++ increased the Heinz body susceptibility of adult erythrocytes to the level known from newborn infants.

ISSN:0001-5792    

DOI:10.1159/000208387

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In 3 patients with myeloma and paraprotein containing cells in the peripheral blood, we demonstrated by an immunofluorescent technique an increase in the number of lymphocytes and plasma cells with immunoglobulin determinants of paraprotein class specificity. Lymphocytes found with mebranous and intracytoplasmic paraprotein content were considered as intermediate forms in plasma cell development. Some possible disturbances of cell proliferation known in lymphoproliferative diseases are discussed.

ISSN:0001-5792    

DOI:10.1159/000208388

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Components of the fibrinolytic enzyme systern were measured in 40 patients with malignant lymphomas. Fibrinolytic activity, as assessed by the euglobulin clot lysis time, was reduced in the majority of patients. The mean fibrinogen level was elevated in patients with Hodgkin’s disease and reticulum cell sarcoma. Four patients in the terminal phase of their illness had a marked reduction in plasminogen. α1-Antitrypsin and serum activation inhibitor levels were increased; α2-macroglobulin levels were normal. No patient had conclusive evidence of disseminated intravascular coagulat

ISSN:0001-5792    

DOI:10.1159/000208389

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

An easy, economic and standardised method of orientation about the 3 most important platelet functions, out of a small quantity of blood is described. In order to examine the reliability of this method a comparative study between the aggregation results in the counting chamber and the platelet aggregation test (PAT) according to BreddIN was carried out. To obtain an exact determination of aggregation in the counting chamber not only the classification into aggregation grades (visual criterium) was taken but also after counting the ‘free platelets’ the aggregation index (PAgI) according to Reuter et al. was calculated. The good concordance of the comparative results of these 2 technically totally different methods are discus

ISSN:0001-5792    

DOI:10.1159/000208390

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Severe factor IX deficiency (Christmas disease) in a phenotypically normal girl prompted a cytogenetic study of the proband and her parents which showed, in the patient, a karyotype with 46 chromosomes (XX ring) and a karyotype comprised of 45 chromosomes with a single X chromosome (45XO). The parents were cytogenetically normal. The activity of factor IX in the patient was markedly abnormal (less than 1%). It is suggested that XX (ring)XO mosaicism permitted expression of the abnormal X-linked gene.

ISSN:0001-5792    

DOI:10.1159/000208391

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A new case with the abnormal factor X (factor X Friuli) coagulation disorder is presented: a 32-year- old female who was born outside Friuli and who complained of a bleeding tendency since childhood. The main laboratory features are prolonged prothrombin time, prolonged partial thromboplastin time, abnormal thromboplastm generation and normal Stypven-cephalin clotting time. The prothrombin time and the thromboplastin generation were corrected by the addition of normal serum. Factor X was low only when assayed using whole tissue or partial thromboplastin. It was normal using the Stypven-cephalin mixture. The cross-over electrophoresis showed a normal factor X band in the patient’s plasma, whereas no band was present in Mr. Stuart’s plasma. The father and a cousin of the patient are heterozygotes for the abnormality. This is the first family reported to have the abnormal factor X (factor X Friuli) disorder outside Fri

ISSN:0001-5792    

DOI:10.1159/000208392

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

An 18-year-old man was bitten by Echis colorata in his left ankle. The patient was followed for 4 days without any therapy and coagulation studies proved fibrinolysis without disseminated intravascular coagulation.

ISSN:0001-5792    

DOI:10.1159/000208393

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208394

出版商:S. Karger AG    

年代:1973

数据来源: Karger