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1. |
Fibrinolysis in Myelomatosis |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 65-70
F.E. Preston,
D. Lee,
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摘要:
The fibrinolytic system has been studied in 12 patients with myelomatosis. Ten had some impairment of their fibrinolytic mechanisms and 4 of these had laboratory evidence of intravascular coagulation. Defective fibrinolysis may be an important factor in the pathogenesis of thromboembolicphenomena in myelomatosis.
ISSN:0001-5792
DOI:10.1159/000208497
出版商:S. Karger AG
年代:1972
数据来源: Karger
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2. |
L-Asparaginase Effect on the Erythrocyte-Immunoglobulin Binding in Acquired Hemolytic Anemia |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 71-80
J. Mirecka,
G. Astaldi,
Z. Szmigiel,
J. Lisiewicz,
M. Wazewska-Czyzewska,
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摘要:
The possibility of direct release of immunoglobulin from the erythrocyte surfaces due to the break of the erythrocyte-immunoglobulin binding after the i.v. administration of L-asparaginase has been shown in patients with acquired hemolytic anemia of IgG and IgA type. These studies were carried out by means of immunofluorescent observation, the determination ofthe immunoglobulin content in the serum, and the direct antiglobulin test.
ISSN:0001-5792
DOI:10.1159/000208498
出版商:S. Karger AG
年代:1972
数据来源: Karger
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3. |
‘Prophylactic’ Treatment of Meningeal Leukemia in Children by Intrathecal Methotrexate |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 81-88
I. Wahidijat,
A.H. Markum,
Maria Abdulsalam,
S. Muslichan,
O. Odang,
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摘要:
The survival period of children suffering from leukemia could be prolonged by using the new antileukemic agents. On the other hand, the frequency of central nervous system involvement as a complication of this disease was very high, i.e. 10 of 19 cases. Six showed signs of meningeal leukemia while they were in hematologic remission and the other 4 were within acute stage. Nine children were given methotrexate intrathecally as a prophylactic measure at the time when diagnosis of leukemia was confirmed, and did not suffer from this complication during follow-up to 6–13 months. From these data we conclude that the regular administration of methotrexate intrathecally to leukemic patients as a prophylactic measure, with routine spinal fluid examinations, is very useful in preventing or in reducing the central nervous system involvemen
ISSN:0001-5792
DOI:10.1159/000208499
出版商:S. Karger AG
年代:1972
数据来源: Karger
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4. |
Eine einfache Methode der Knochenmarkkurzzeitkultur |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 89-97
G. Bach,
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摘要:
A rapid method of culturing bone marrow fragments in liquid medium under standard conditions is described. The suitability of various media has been investigated, and these are characterized according to their morphological features, cell counts and determination of the mitotic index.
ISSN:0001-5792
DOI:10.1159/000208500
出版商:S. Karger AG
年代:1972
数据来源: Karger
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5. |
The Urinary Excretion of Haemoglobin in the Isolated Normothermic-Perfused Dog Kidney |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 98-108
J. de Schepper,
J. van der Stock,
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摘要:
The isolated kidney handles haemoglobin in the same manner as the kidney in vivo. There is no excretion of haemoglobin when the haemoglobin-binding capacity is not saturated. When this is done and a free plasma haemoglobin level exists, the clearance of free haemoglobin had an average value of 3.24 ± 2.92 ml/min. The glomerular clearance ratio of haemoglobin averaged 0.10 ± 0.06. The calculated rate of tubular reabsorption of haemoglobin was 2.06 ± 3.12 mg/min. The graphic relationship between urinary excretion and plasma levels of free haemoglobin was linear. The theoretical plasma level above which haemoglobinuria occurred was 64.0 ± 35.2 mg%. These last two data are more suggestive of tubular reabsorptive activity than the calculated val
ISSN:0001-5792
DOI:10.1159/000208501
出版商:S. Karger AG
年代:1972
数据来源: Karger
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6. |
Endocrine Studies in a Case of Congenital (Erythroid) Hypoplastic Anaemia |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 109-117
C.M. Steel,
S.T.G. Butterworth,
A.J. Keay,
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摘要:
Congenital (erythroid) hypoplastic anaemia was diagnosed in a newborn male infant whose progress was followed until death at the age of 18 years. He received a total of 456 units of blood and developed obvious transfusion haemosiderosis. He showed total arrest of growth from the age of 9 years and remained sexually infantile. These features are common accompaniments of this haematological disorder. In addition, our patient became severely hypothyroid. Endocrine studies provided limited evidence for an anterior pituitary lesion and at post mortem, the pituitary gland, in common with all the internal organs, was found to contain haemosiderin deposits. The suggestion is made that endocrine features in this condition are secondary to iron overload rather than part of the fundamental disorder. A therapeutic trial of human growth hormone may prove of value in such patients.
ISSN:0001-5792
DOI:10.1159/000208502
出版商:S. Karger AG
年代:1972
数据来源: Karger
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7. |
Thalassaemia Major with Complete Suppression of HbA Production in a Ghanaian Girl |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 118-126
Bela Ringelhann,
Ann L. Rudwick,
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摘要:
A 7-year-old Ghanaian girl showed severe hypochromic anaemia, hepatosplenomegaly, widening of the diploic space and a hair on end appearance on a skull X-ray. Hb electrophoresis revealed only one thick band, which was HbF, no HbA was present. Both the mother and her brother are β-thalassaemia traits; it was impossible to investigate the father. Very few communications are available on thalassaemia major among Negroes. The view is expressed that there is a heterogeneity of the thalassaemia gene in Africans, and all the cases published previously have HbA in addition to HbF. The present case belong to another group where the β -chain is suppressed completely. It is assumed that in Africa, children with thalassaemia major die in early childhood without proper diagnosis and only those survive who have a milder course, however, those may also die before they reach the end of the first decade. Further case reports and clinical and laboratory studies are necessary to obtain more information on thalassaemia major in African
ISSN:0001-5792
DOI:10.1159/000208503
出版商:S. Karger AG
年代:1972
数据来源: Karger
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8. |
Libri |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 127-127
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ISSN:0001-5792
DOI:10.1159/000208504
出版商:S. Karger AG
年代:1972
数据来源: Karger
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9. |
Varia |
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Acta Haematologica,
Volume 47,
Issue 2,
1972,
Page 128-128
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ISSN:0001-5792
DOI:10.1159/000208505
出版商:S. Karger AG
年代:1972
数据来源: Karger
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