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1. |
Proliferation Disturbances of Erythroblasts in Congenital Dyserythropoietic Anemia Type I and II |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 65-76
W. Queisser,
E. Spiertz,
E. Jost,
H. Heimpel,
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摘要:
DNA synthesis of erythroblasts in congenital dyserythropoietic anemia (CDA) type I and II was studied. In CDA type I, hypertetraploid and octoploid cells are present in all stages of maturation. In polychromatic normoblasts, only a few labelled cells are observed and the majority of cells show DNA values in the pretetraploid range. The results suggest a disturbance of mitotic division which becomes apparent already in the basophilic stage, and an arrest of DNA synthesis in the more mature nucleated red cells, dependent from cytoplasmic hemoglobin concentration. In CDA type II, a shift of the G1/S ratio was observed in mononucleated and binucleated polychromatic cells consistent with repression of DNA synthesis-induction earlier than normal. The binucleated cells are probably the result of normal karyokinesis not followed by cytoplasmic division
ISSN:0001-5792
DOI:10.1159/000208608
出版商:S. Karger AG
年代:1971
数据来源: Karger
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2. |
Decreased Hemoglobin A2Concentration in Iron Deficiency Anemia |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 77-81
J. Steiner,
H.R. Marti,
D. Dean,
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摘要:
A comparison of the Hb A2 concentration in 100 patients with iron deficiency anemia and 100 healthy adults shows a significant decrease in cases with iron deficiency (p = < 0.05). The mean value was 1.8% for the iron deficient patients and 2.3% for controls. The 2s range was found to be 1.1–2.4% and 1.7–2.9% respectively. No correlation between the amount of Hb A2 decrease and the degree of anemia and hypochromia could be demonstr
ISSN:0001-5792
DOI:10.1159/000208609
出版商:S. Karger AG
年代:1971
数据来源: Karger
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3. |
RNA and Protein Synthesis in Proliferating and Non-Proliferating Blast Cells of Human Acute Leukaemia |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 82-88
B.W.B. Chan,
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摘要:
Cell size can be used to distinguish between the proliferative and the non-proliferative or resting cells in human acute leukaemia. The large, proliferative blast cells not only have a higher rate of RNA synthesis, but also synthesise more labile RNA, compared to the smaller, resting cell. No difference in the life-time of templates was found between the two cell types
ISSN:0001-5792
DOI:10.1159/000208610
出版商:S. Karger AG
年代:1971
数据来源: Karger
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4. |
Lymphoid Myelofibrosis |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 89-98
G. Duhamel,
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摘要:
Lymphoid myelofibrosis represents an anatomoclinical syndrome of constant symptomatology characterized predominantly by splenomegaly, few lymphadenopathies, pancytopenia with blood lymphocytosis, and a hypoplastic myelogram comprising lymphocytes and histiocytes. Histological study of bone marrow biopsy shows association of lymphoid proliferation as well as network cell proliferation, giving rise to a dense lattice of reticulum and collagen fibers, without osteosclerosis. The cytology of the syndrome and its relationship to lymphoid leukemia, Waldenström’s disease and those syndromes termed reticuloendotheliosis or malignant histiocytosis is discussed. It is not easy to evaluate the efficiency of therapeutic measures, since myelofibrosis precludes that kind of chemotherapy as is currently used in lymphoproliferative syndromes; therefore, prognosis is incertain although clinical evolution is s
ISSN:0001-5792
DOI:10.1159/000208611
出版商:S. Karger AG
年代:1971
数据来源: Karger
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5. |
Significance of Abnormal LDH Isoenzyme Pattern in Human Platelets |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 99-105
Finn Ursin Knudsen,
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摘要:
The distribution of lactate dehydrogenase (LDH) isoenzymes in platelets from 41 normal persons and 59 patients was studied by disc polyacrylamide electrophoresis. The results were analysed statistically. Compared to the normal controls, a group of bleeding/ surgical patients, expected to exhibit a predominance of young platelets, showed a significant decrease in the ratio between H and M monomers (decrease in T-value). Within a group of myelo- and lymphoproliferative disorders, normal T-values were found in essential thrombocythaemia, chronic myeloid leukaemia, blastic leukaemia, and chronic lymphatic leukaemia. In myelofibrosis, T-values were significantly decreased, while in polycythaemia vera they were increased
ISSN:0001-5792
DOI:10.1159/000208612
出版商:S. Karger AG
年代:1971
数据来源: Karger
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6. |
Carrier Proteins of Folic Acid Activity in Human Serum |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 106-111
T. Markkanen,
O. Peltola,
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摘要:
The natural folic acid activity (FAA) in the serum, on Sephadex® G-200 gel filtration, is divided into 3 fractions: the first in the band of largemolecular proteins; the second in that of small-molecular proteins; and the third outside the protein band. The second fraction, in the present study, was purified by hydroxyapatite chromatography, with the result that FAA emerged over a narrow area of fractions. In immunoelectrophoresis anddisc electrophoresis this area contained only albumi
ISSN:0001-5792
DOI:10.1159/000208613
出版商:S. Karger AG
年代:1971
数据来源: Karger
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7. |
The Occurrence of Homozygous Hemophilia in the Female |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 112-119
H. Morita,
M. Kagami,
Y. Ebata,
H. Yoshimura,
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摘要:
A case of homozygous hemophilia in a female is reported. Her father was hemophiliac and her mother was carrier of hemophilia. She has 2 sons who are both hemophiliacs. The patient has had many bleeding episodes. The laboratory studies revealed that the patient has impaired clotting mechanism attributable only to factor VIII deficiency
ISSN:0001-5792
DOI:10.1159/000208614
出版商:S. Karger AG
年代:1971
数据来源: Karger
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8. |
Prophylaxis of Joint Hemorrhages in Hemophilia |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 120-127
S. van Creveld†,
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摘要:
A description of the continued experience acquired by transfusion of cryoprecipitates respectively 2 and 3 times a week in the prophylactic treatment of 2 young patients with hemophilia A now extending over periods of almost 3 years and more than 2½ years. The conclusion that with 3 transfusions per week of one cryoprecipitate, equivalent to 900–1,500 U of AHF weekly, effective prophylaxis of joint hemorrhages is achieved in these patients, seems justified. During these periods hospital admissions were reduced to a few only, and were with one exception on account of a trauma. Radiologically the changes in the joints already existing before prophylactic treatment was started, showed practically no progress
ISSN:0001-5792
DOI:10.1159/000208615
出版商:S. Karger AG
年代:1971
数据来源: Karger
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9. |
Libri |
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Acta Haematologica,
Volume 45,
Issue 2,
1971,
Page 128-128
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ISSN:0001-5792
DOI:10.1159/000208616
出版商:S. Karger AG
年代:1971
数据来源: Karger
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