摘要:

18 patients with malignant lymphoma ‘histiocytic type’ were investigated for the bone marrow involvement. Bone marrow aspirates and needle biopsies were used. Smears and sections of the aspirates were examined. The findings in the sections of both aspirates and biopsies were complementary and far more valuable than the bone marrow smears alone. It is concluded that bone marrow examination is helpful in determining the spread of the disease and should be repeated during the course of lymph

ISSN:0001-5792    

DOI:10.1159/000208044

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The erythropoietic part of the bone marrow has been morphologically analysed in 34 untreated, anaemic patients with acute myeloid leukaemia and in 17 healthy controls. In the patients with leukaemia the percentage of basophilic erythroblasts was abnormally high and elevated mitotic indices of the erythroblasts were recorded. The accumulation of basophilic erythroblasts and a high frequency of megaloblastoid changes of the cells may indicate ineffective erythropoiesis. A threefold increase of ‘erythroblastic islands’, i. e. erythroblasts in contact with reticulum cells were recorded in the patients with erythroleukaemia and a twofold increase in the patients with acute myeloid leukaemia. The erythroblastic islands may indicate phagocytosis of defective erythroblasts and an intramedullary haemolysis may thus contribute to the development of anae

ISSN:0001-5792    

DOI:10.1159/000208045

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Investigations with the electron microscope on peripheral blood of patients with Hodgkin’s disease revealed parallel tubular structures in the cytoplasm of the lymphocytes, similar to those described in the literature. In normal subjects 2–9% of the lymphocytes were found to contain these structures. The number of such lymphocytes is increased in most patients as compared to normals. A correlation between an increase of inclusions containing lymphocytes and the histological or clinical classifications could not be established. An elevation of lymphocytes with tubular structures could be found in both favourable and unfavourable histological and clinical subgroups of Hodgkin patients, but especially in all groups with an unfavourable prognosis. The origin and function of the parallel tubular structures is still unknown, but their increase in lymphocytes of patients with Hodgkin’s disease is of some interest in view of the involvement of these

ISSN:0001-5792    

DOI:10.1159/000208046

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

In patients with HBAg-positive and HBAg-negative viral hepatitis the etiocholanolone test showed a decrease of the bone marrow granulocyte reserve at the height and, though at a lower degree, at the end of the disease. These results are discussed in relation with the incidence of aplastic anemia following viral hepatitis.

ISSN:0001-5792    

DOI:10.1159/000208047

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

In a series of 18 known and 14 possible carriers of haemophilia A the factor VIII-related antigen was assayed. Comparison of results with the biological activity of factor VIII detected correctly 17 of 18 known carriers. On the other hand the carrier state was detected in 8 of 14 possible carriers. The results are similar to those of other investigators.

ISSN:0001-5792    

DOI:10.1159/000208048

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Glomerulonephritis in idiopatic mixed cryoglobulinemia represents perhaps a glomerular damage by immune complexes. In this study, a sigmoidal-like curve was obtained after addition of 13 different mixed cryoglobulins to both autologous and isologous platelet-rich plasma, tested in platelet aggregometer. The lag phase of the curve corresponds to platelet phagocytosis of cryoglobulin-binding ferritin, as shown in electron microscopy and the optical density decrease phase corresponds to the aggregation of platelets that shows the same ultrastructural characteristics of ADP-induced platelet aggregation. This platelet aggregation is inhibited by different drugs. Intraglomerular platelet aggregation by cryoglobulins might play a key role in determining the glomerular damage in cryoglobulinemia by the release of nucleotides and vasoactive amines.

ISSN:0001-5792    

DOI:10.1159/000208049

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The influence of Peptichemio® (m-dichloroethyl-amino-1-phenylalanyl-peptide complex) on the following platelet functions was studied: aggregation, release of platelet factor 4, availability of platelet factor 3, acid phosphatases and reptilase clot retraction. Concentrations of the drug corresponding to that found in plasma of treated patients did not significantly influence platelet functions. Concentrations 10 times higher brought about an inhibition. It is concluded that after current dosage of Peptichemio, bleeding disorders caused by impairement of platelet functions are improbable

ISSN:0001-5792    

DOI:10.1159/000208050

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The electrophoretically fast-moving hemoglobin variant Hb Camden [β 131 (H9) glnn→ glu] has been found in a middle-aged female suffering from pulmonary disease, and Hb Hope [β 136 (H14) gly→asp] which migrates just ahead and very close to Hb A was present in a young obstetrical patient with a mild hemolytic a

ISSN:0001-5792    

DOI:10.1159/000208051

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudodiploidy: one of the chromosomes 12 was missing and one submedian marker chromosome of medium size and atypical morphology appeared.

ISSN:0001-5792    

DOI:10.1159/000208052

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208053

出版商:S. Karger AG    

年代:1975

数据来源: Karger