摘要:

We have demonstrated the log normality of the distribution of sheep rosette-forming cells and mouse rosette-forming cells’ values obtained with lymphocytes isolated from the peripheral blood of 135 healthy human beings and 57 patients suffering from chronic lymphocytic leukemia and well differentiated lymphocytic lymphosarcoma with bone marrow infiltration either in evolution or in remission. In evolutive cases, the absolute numbers of mouse rosette-forming cells rose as well as the lymphocytosis, whereas the absolute numbers of sheep rosette-forming cells were normal or even increased in spite of an impressive drop of their percentage. In nonevolutive cases, the absolute numbers of sheep rosette-forming cells and mouse rosette-forming cells were lowered to half of the normal values as a consequence of the lymphopenia induced by chemotherapeutic agent

ISSN:0001-5792    

DOI:10.1159/000207783

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Thalassaemia with normal levels of Hb A, and Hb F and with an α/β ratio higher than 1 is described in 4 families. 3 of these families show direct or indirect signs of the presence of the δ-thalassaemia gene along with the β-thalassaemia gene. The fourth family leaves the question as to whether there is a single mutation of the δβ tract or a β + δ-thalassaemia in coupling unanswered. The necessity of knowing of the existence of this thalassaemia which conceals the presence of a β-thalassaemia gene, is stressed, above all in view of the danger that mating between a carrier of this thalassaemia and a carrier of classical β-thalassaemia could result in the birth of children with Cooley

ISSN:0001-5792    

DOI:10.1159/000207784

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The haematological findings resulting from the interaction of Hb A2Indonesia trait with β-thalassaemia trait and HbA2Indtrait with Hb E trait are discussed. A person doubly heterozygous for Hb A2Ind and β-thalassaemia had mild haematological abnormalities essentially similar to those found in persons with β-thalassaemia trait alone. A carrier for both Hb A2ιnd trait and Hb E trait had essentially normal haematological findi

ISSN:0001-5792    

DOI:10.1159/000207785

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Methemoglobinemia and mental retardation associated with NADH-diaphorase deficiency was found in a 2-year-old girl of Spanish origin. She showed no NADH-diaphorase activity in either erythrocytes or leukocytes, but electrophoretic studies of the hemolysate showed traces of an enzyme with normal mobility. Cytochrome b5 reductase activity was also found to be absent in the leukocytes of the propositus. Intermediate NADH-diaphorase activity was found in erythrocytes and leukocytes in her parents and her sister in accordance with the autoso-mal recessive mode of inheritance of this enzymopathy. The relationship between a generalized cytochrome b5 reductase deficiency and the progressive neurological involvement in our patient is discussed briefly.

ISSN:0001-5792    

DOI:10.1159/000207786

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A patient with chronic myelocytic leukemia in whom a clinical and hematological remission occurred after a single course of busulfan is described. The remission lasted for a period of 13 years and during that lapse of time, she gave birth to a healthy child. Afterwards, acute myeloblastic leukemia was diagnosed. Following treatment with rubidomycin and arabinoside C another remission was achieved, lasting already for 18 months.

ISSN:0001-5792    

DOI:10.1159/000207787

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207788

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207789

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207790

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207791

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207782

出版商:S. Karger AG    

年代:1978

数据来源: Karger