摘要:

Lymphocytes from 107 healthy individuals and 34 patients with lung cancer were cultured and stimulated with PHA. Wide variation in lymphocyte transformation reactivity was observed, ranging from significantly low responses to high blastogenesis. Low spontaneous blastogenic responses were not always associated with a simultaneous decrease in PHA-induced lymphocyte transformation in the same individuals. The results are presented by the (disintegrations per minute) values of the stimulated and nonstimulated cultures and by the stimulation index. A new index termed the Blastogenic Cumulative Index is proposed. It is defined as the sum of the logarithms of the values of the spontaneous and the PHA-induced lymphocyte transformation. A better relationship was observed in immunocompetent and in immunodepressed individuals between the dpm values and Cumulative Indices than between the dpm and the Stimulation Indices.

ISSN:0001-5792    

DOI:10.1159/000207101

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The incidence of the blood committed granulocyte progenitor cells (CFU-C) before and after epinephrine administration has been studied in 10 normal, 16 splenomegalic and 8 splenectomized subjects through a double-layer agar culture system. A significant increase of the mean values of CFU-C per milliliter of blood has been observed after epinephrine administration in normal and in splenomegalic subjects. In splenectomized patients the baseline mean values of CFU-C per milliliter of blood were higher than those observed in the other groups of subjects, but they did not increase after epinephrine infusion. The concentration of CFU-C per 106 total blood leukocytes was the same in all three groups of subjects and it was not modified by epinephrine administration. Our results seem to indicate that the CFU-C are distributed in two blood compartments, the spleen representing an important section of the marginal compartment of the blood CFU-C.

ISSN:0001-5792    

DOI:10.1159/000207102

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Creatine in density-fractionated red cells is not only a useful criterion of cell age but also an excellent indicator of erythropoietic dnyamics particularly under the influence of present and past hypoxia. This is documented on patients with cardiac hypoxia. A histogram is proposed which permits the simultaneous evaluation of four parameters: (1) the creatine concentration of each separate fraction, (2) the absolute density of a given cell fraction, (3) the percentage distribution of cells over the whole gradient and within the different fractions and (4) the general position of the red cell population with respect to its median density, which serves to characterize the overall age of a red cell population. Creatine histograms on fractionated red cells are shown to be useful aids for diagnosis and prognosis in hypoxic clinical states. They may also give retrograde information on past stimulation of erythropoiesis.

ISSN:0001-5792    

DOI:10.1159/000207103

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A longitudinal study has been conducted on serum ferritin concentrations in children with thalassemia major treated with desferrioxamine (DFO), both intramuscularly and by continuous subcutaneous infusion, in order to evaluate the time interval after which iron chelation becomes effective. In a first group of 19 children, treated intramuscularly with DFO at a dose of 20 mg/kg for 20 days a month, ferritin levels were followed for 739 days and a progressive increase with a significant linear correlation with time was seen. The daily increase was calculated to be 8.53 ± 1.95 ng/ml. In the second group of 12 children treated with DFO by continuous subcutaneous infusion (≥ 20 mg/kg/day for 6 days a week), the increase in ferritin was markedly lower, the mean daily value being 4.77 ± 3.30 ng/ml. Only after the first 360 days of treatment did the serum ferritin decrease, by 1.95 ± 3.32 ng/ml/day, in spite of a mean daily iron contribution from blood transfusions of 7.09 ± 2.69 mg/day. These changes in serum ferritin led us to conclude that one can only expect to obtain a decrease in the body’s iron overload after more than a year of treatment with subcutane

ISSN:0001-5792    

DOI:10.1159/000207104

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

This work was carried out to demonstrate the possibility of beneficial therapeutic effects of aspirin in sickle cell anaemia patients. Two groups of 50 patients each, with haemoglobin genotype SS were studied, one group receiving soluble aspirin daily for 6 weeks, while the other was used as a control. There was evidence of increase in oxygen affinity, in haemoglobin levels, and in the life span of RBC, probably due to acetylation of HbS.

ISSN:0001-5792    

DOI:10.1159/000207105

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

This report is concerned with the evaluation of hematological parameters and the percentage level of the abnormal hemoglobin (Hb) G San José as found in 4 heterozygous carriers from a family of Sicilian origin. Biosynthetic studies and in vitro recombination experiments strongly indicate that abnormal β chains are synthesized at lower rate than βA chains and exhibit a minor affinity (relative to β chains) for complementary chains in a condition of relative αA chain deficiency. The possibility that the low affinity of βG chains for α chains may play a decisive role in controlling the level of the abnormal Hb in the peripheral blood of the present non-α-thalassemic abnormal Hb carriers is therefore di

ISSN:0001-5792    

DOI:10.1159/000207106

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The concentrations of serum immunoglobulins were determined in 44 adults with idiopathic thrombocytopenic purpura. A significant reduction of the mean IgA level was observed, while no differences were demonstrated as concerns IgG and IgM levels.

ISSN:0001-5792    

DOI:10.1159/000207107

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Three infusions of vincristine-loaded platelets were carried out in a young man with acute idiopathic thrombocytopenic purpura (ITP) refractory to steroids. This procedure, used until now only for chronic refractory ITP, insured a remission without side effects. After 2 years of follow-up the patient has not had relapse. A potentially dangerous splenectomy was thus avoided in a phase of the disease in which a spontaneous remission was still very probable.

ISSN:0001-5792    

DOI:10.1159/000207108

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Different patterns of acid alpha-naphthyl-acetate esterase (ANAE) positivity in lymphocytes have been related to distinct functional lymphocyte subpopulations. A case of T-ALL with a cytochemical and immunological phenotype consistent with a T-suppressor cell leukemia is reported. In particular a specific pattern of Golgi-ANAE positivity is probably characteristic of TG cells, which include a subset with suppressor function.

ISSN:0001-5792    

DOI:10.1159/000207109

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Anomalous cells of the Pelger-Huët type appear mainly in diseases affecting granulopoiesis such as myeloproliferative disorders, aplastic anemia and agranulocytosis [1]. The association of this anomaly with disorders of the lymphatic system is rare and had been described only in 1 patient with chronic lymphocytic leukemia [2]. Recently we have encountered another patient with chronic lymphocytic leukemia and acquired Pelger-Huët anomal

ISSN:0001-5792    

DOI:10.1159/000207113

出版商:S. Karger AG    

年代:1981

数据来源: Karger