摘要:

In vitro autohaemolysis with and without the addition of glucose was performed on normal pregnant women chosen at random and on non-pregnant women of comparable age. Autohaemolysis was significantly greater in the pregnant than the non-pregnant. The relationship between the stage of gestation and in vitro autohaemolysis in normal pregnancy may be fitted by a quadratic curve.

ISSN:0001-5792    

DOI:10.1159/000207425

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

This report is concerned with the evaluation of hematological parameters and of both relative (%) and absolute (mean pg/cell) quantities of the abnormal Hemoglobin (Hb) Hasharon in 53 heterozygous carriers and 7 double heterozygotes for Hb Hasharon and β-Thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an α-thalassemia-2 determinant closely linked to the αHasharon-chain locus. Selective advantage of heterozygotes carrying such α-haplotype would explain the relatively high frequency of Hb Hasharon (0.23%) in northeastern Italy, a past-endemic malaria region. The interaction between Hb Hasharon and β-Thalassemia results in preferential decrease of the abnormal Hb l

ISSN:0001-5792    

DOI:10.1159/000207426

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The buoyant densities of human erythrocytes with normal (HbAA) and abnormal heterozygous haemoglobins (HbSS, HbAS, HbSC) as well as erythrocytes from guinea pig and pigeon were determined by centrifugation in discontinuous density gradients of metrizamide. Guinea pig, pigeon and human erythrocytes from normal human adult (HbAA) and from heterozygote HbAS were found to have the same density of 1.1381 g/cm3, while erythrocytes from a sickle-cell patient (HbS) and from a heterozygote HbSC, HbSS and HbSC, which are known to have a higher lipid content than isovolumic normal cells, had a lower density of 1.1261 g/cm3. When centrifugation was carried out under non-equilibrium conditions (rate zonal), several sedimentation bands were obtained from each erythrocyte preparation. Differences in the sedimentation rates were unrelated to the haemoglobin composition of the erythrocytes. It is suggested that the lower density of the erythrocytes associated with sickle-cell disease may have significant consequences in the circulation of such cells and in the clinical sequence of the sickling process.

ISSN:0001-5792    

DOI:10.1159/000207427

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

75 cases of acute myeloid leukaemia were retrospectively classified according to the French-American-British (FAB) classification. It was found that: (1) the proposed classification was easily applicable and reproducible; (2) M2 subtype was the most frequent (48%(3) splenomegaly was absent in M1 subtype, and (4) in M2 subtype, a considerable number of cases presented with normal neutrophil and platelet counts.

ISSN:0001-5792    

DOI:10.1159/000207428

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The isoenzymes of nonspecific esterases have been examined with polyacrylamide gel electrophoresis in 10 patients with chronic myelocytic leukemia (CML) and 10 with blastic crisis (BC) in respect to normal subjects. In patients with active CML the recurrent loss of fast bands was detected, while in patients in remission the isoenzyme variants are similar to those found in normal subjects. Different isoenzyme variants which are similar to those found in acute leukemia were detected in patients with BC of different morphological type with the exception of BC of megakaryoblastic type. The possible meaning of such variants in relation to an early identification of malignant proliferating clones, is discussed.

ISSN:0001-5792    

DOI:10.1159/000207429

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Postphagocytic chemiluminescence of neutrophils was evaluated in infants throughout the 1st month of life, in their mothers and healthy adults to investigate further the defective chemiluminescence of neonatal neutrophils described by earlier studies. Maternal and adult values were similar and served as controls. Abnormalities both of peak chemiluminescence and of the kinetics of light emission were detected in infant neutrophils throughout the 1st month of life. Infant responses were variable, particularly at birth, when neutrophils of some infants performed comparably to those of controls.

ISSN:0001-5792    

DOI:10.1159/000207430

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The occurrence of Burkitt’s lymphoma (BL) following Hodgkin’s disease (HD) has not yet been reported. A patient treated for HD by chemotherapy-radiotherapy association developed a BL 6 years later: it was demonstrated by cytological, cytochemical, immunological and cytogenetical – translocation t (8; 14) – characteristics. Our hypothesis is that, in this case, BL may be the consequence of chemotherapy-radiotherapy asso

ISSN:0001-5792    

DOI:10.1159/000207431

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Two patients with factor VII Padua abnormality were studied during prophylactic administration of factor VII concentrates for tooth extractions. The amounts administered were 15.8 and 17.2 units/kg body weight in 30 and 20 min, respectively. The end infusion factor VII activity levels were 55 and 64%, respectively. Survival times of the exogenous components were 6.5 and 6 h, respectively. Satisfactory hemostasis was obtained in both instances.

ISSN:0001-5792    

DOI:10.1159/000207432

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protamine test but a normal antithrombin III level. These observations suggest that coagulation abnormalities appearing in acute leukemia are not necessarily due to diffuse intravascular coagulation.

ISSN:0001-5792    

DOI:10.1159/000207433

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207434

出版商:S. Karger AG    

年代:1980

数据来源: Karger