摘要:

The biosynthesis in vitro of immunoglobulins was studied in 13 patients with primary immunological deficiencies. Bone marrow, tonsils, lymhocytes, intestinal mucosa of congenital agammaglobulinaemic, and acquired hypogammaglobulinaemicpatients showed a very marked reduction of H- and L-immunoglobulin chains. In 3 patients with dysgammaglobulinaemia, there was a selective deficiency of the H-chain restricted to classes lacking in the serum, whereas in 1 patient with absence of IgA serum, the tissue culture of lymphocytes was positive for this immunoglobulin. These results are discussed with respect to the pathogenesis of immunological defects.

ISSN:0001-5792    

DOI:10.1159/000208448

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Plasma radioactivity following the simultaneous oral administration of vitamin B12 labelled with 2 test isotopes of cobalt (‘Dicopac’ test) was measured in 19 control subjects and in 19 patients suffering from pernicious anaemia. One isotope (58Co) was free, while the other (57Co) was bound to normal human gastric juice. Results of diagnostic value were obtained on 80% of occasions; misleading results occurred in the other 20%. It is concluded that this test is of little value in routine diagnostic haematol

ISSN:0001-5792    

DOI:10.1159/000208449

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

α2-Macroglobulin, a carrier of folic acid activity (FAA), was isolated from fresh human serum by DEAE Sephadex A-50 gel chroma-, tography. The FAA content of the maximum with α2-macroglobulin was 136 pg/mg protein and constituted 42% of the FAA eluated with the totalproteins from the chromatography column. Theresults was corroborated by controlled retestin

ISSN:0001-5792    

DOI:10.1159/000208450

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

For the first time the distribution of pecific cholinesterases in cells of the intact bone marrow (megakaryocytes and precursor cells) of the penis bone of rats and mice is presented. Theresults are compared with findings in particles ofbone marrow already published.

ISSN:0001-5792    

DOI:10.1159/000208451

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The in vitro 3H-TdR labelling index of eosinophil myelocytes in normal human bone marrow was 16.1%. A similar value was observed in with eosinophilia. Considerably higher – belling indices were seen in the eosinophil myelo- cytes of 1 folate deficient and 2 vitamin B12 deficient patients. Another 6 patients with megaloblastic haemopoiesis showed normal or near-normal eosinophil myelocyte labelling indices despite the presence of elevated labelling indices in the neutrophil promyelocyte-myelocyte pool in 5 of them. The results indicate some differences in the cytokinetic disturbances affecting neutrophil and eosinophil granulocytopoiesi

ISSN:0001-5792    

DOI:10.1159/000208452

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The content of phosphate compounds in blood conserved at 2–4 °C in ACD, ACD with adenosine and ACD with adenosine and persantin has been investigated. The decomposition of high-energy phosphate compounds (and 2,3-DPG) was much slower in the solution containing adenosine withpersantin than in two other media during the 6-week period of blood conservation. The clinical importance of the application of persantin for the prolongation of blood conservation is discuss

ISSN:0001-5792    

DOI:10.1159/000208453

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Two unrelated black children (male and female) mild diathesis were found to be factor V deficient «1 and 2.5%). One was agnosed at one week of age, the other later in included umbilical hemorrhageepistaxisgas Platelet function trointestinal bleeding and hemorrhage following oral mucous membrane lacerations. The factor V level in the mother of one patient was borderline low while factor V levels in the parents of the other child were normal. studies on both children were normal

ISSN:0001-5792    

DOI:10.1159/000208454

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

A case of fast, deadly cryoglobulinemia is described. From the gradient separation, the dissolved cryogel resulted in 2 peaks (21–22S and 7S). Both fractions showed a double immuiseases nological specifity (IgM and IgG). The heavy peak contained complexes of 19S and 7S with very stable bond, not belonging to the ‘rheumatoid factor’ IgG-type. The presence of a component of IgM specifity in the 7S fraction, probably consisting of catabolic products of pathological macroglobulins, corresponds to the high catabolic rate of labelled heavy fra

ISSN:0001-5792    

DOI:10.1159/000208455

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208456

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208457

出版商:S. Karger AG    

年代:1972

数据来源: Karger