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1. |
Drug Induced Immune-Thrombocytopenia |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 1-2
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ISSN:0001-5792
DOI:10.1159/000206940
出版商:S. Karger AG
年代:1982
数据来源: Karger
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2. |
Surface la-Like Expression and MLR-Stimulating Capacity of Human Leukemic Myeloblasts: Implications for Immunotherapy and Prognosis |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 3-13
T.D. Miale,
L.Å.L. Stenke,
J.B. Lindblom,
A.-M. Sjögren,
P.G. Reizenstein,
A.-M. Udén,
D.L. Lawson,
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摘要:
Surface la-positive cells were found to vary from 0 to 100% in initial blood specimens from 37 adults with acute myelogenous leukemia (AML). When myeloblasts from 19 patients were tested against panels of lymphocytes from 5 to 19 normal donors, mean stimulation indices ranged from 1 to 60. Some leukemic myeloblasts strongly stimulated most allogenic responder lymphocytes whereas others produced almost no stimulation. The addition of antibody against human la to 28 mixed leukocyte reaction (MLR) combinations resulted in significant inhibition (p < 0.001) of 3 50% la-positive myeloblasts had a significantly longer survival than patients with fewer la-positive myeloblasts (p < 0.04).
ISSN:0001-5792
DOI:10.1159/000206941
出版商:S. Karger AG
年代:1982
数据来源: Karger
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3. |
Bone Marrow Biopsy in Solid Cancer |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 14-19
Yoram Cohen,
Jamal Zidan,
Dan McShan,
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摘要:
205 patients with solid cancer, underwent bone marrow biopsy using a Jamshidi needle, regular type. 32 (16%) biopsies were positive for bone marrow metastases. Results were correlated with those of skeletal radioisotope scans, X-ray films and the complaint of bone pain, alone or combined. 27 of 131 (17.5%) patients with positive X-ray film and 31 of 110 patients (28.1%) who complained of bone pain had a positive bone marrow biopsy. 17 of 46 (36.9%) patients with 3 positive parameters had a positive bone marrow biopsy as compared with none of 18 patients whose these 3 parameters were negative. Average values of Hb, WBC, serum alkaline phosphata.se and calcium did not differ between patients with positive or negative bone marrow biopsy. 86 patients were diagnosed to have bone metastases and 35 more patients were diagnosed within a year following the biopsy. Of these 121 patients, 46 of 46 with positive scan, X-ray and pain were diagnosed to have bone metastases as compared to 27 of 30 patients with a positive scan with pain but negative X-ray film. Only 1 of 18 patients with negative parameters was diagnosed as having bone metastases within a year from biopsy. In our experience, it is of no value (unlike in malignant lymphoma and oat cell carcinoma of lung) to obtain a bone marrow biopsy for the detection of bone marrow micrometastases in asymptomatic cancer patients with negative skeletal radioisotope scan and negative bone X-ray films.
ISSN:0001-5792
DOI:10.1159/000206942
出版商:S. Karger AG
年代:1982
数据来源: Karger
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4. |
Group-Specific Auto-Immune Antibodies Directed to Granulocytes as a Cause of Chronic Benign Neutropenia in Infants |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 20-27
L.J.M. Sabbe,
F.H.J. Claas,
J. Langerak,
G. Claus,
L.W.A. Smit,
J.H. de Koning,
C.H. Schreuder,
J.J. van Rood,
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摘要:
Chronic benign neutropenia of infancy is a disease which develops a few months after birth and which is characterized by a severe selective neutropenia, accompanied by benign but persisting infections. The cause of the disease is still unknown. The sera from 5 such patients were tested for the presence of granulocyte antibodies as a possible cause of the disease. For the detection of these antibodies immunofluorescence, agglutination and granulocytotoxicity were used. All sera contained antibodies which reacted both with the neutrophils of one or both parents of the patient and a part of a panel of unrelated donors. From the reaction patterns against the panel we could identify the specificity of three sera. Two sera were directed to the neutrophil-specific antigen NA2, and the third one reacted with a hitherto not yet recognized neutrophil-specific alloantigen which we called NE1. In 4 patients we could confirm the autoimmune character of the disease by demonstrating the antibody on the patients’ own granulocytes. These results suggest that autoimmunity may be the cause of many cases of benign infantile neutropeni
ISSN:0001-5792
DOI:10.1159/000206943
出版商:S. Karger AG
年代:1982
数据来源: Karger
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5. |
Use of Antithrombin Concentrate in Stable Diffuse Intravascular Coagulation |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 28-33
Hans L. Haak,
Jean C. Stolk,
Jan W. Gratama,
Harry van Hulsteyn,
Ernest Briet,
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摘要:
A case report is presented of a 39-year-old woman suffering from a myelodysplastic syndrome, who developed a moderately severe stable diffuse intravascular coagulation (DIC) during an uneventful pregnancy. Intravenous administration of antithrombin III concentrate was attempted to combat the DIC. Improved survival of platelet transfusions, facilitating supportive care, suggested some therapeutic benefit. In contrast, only minimal effects on the results of the coagulation tests were observed.
ISSN:0001-5792
DOI:10.1159/000206944
出版商:S. Karger AG
年代:1982
数据来源: Karger
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6. |
Factor VII Padua Defect: The Heterozygote Population |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 34-38
A. Girolami,
Dal Bo Zanon,
F. Zanella,
M. Procidano,
G. Ruffato,
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摘要:
14 heterozygote patients, belonging to three families with factor VII Padua defect were investigated. All patients were asymptomatic but presented a mild prolongation of prothrombin time. Factor VII activity varied between 45 and 61% of normal and no overlap was found with the homozygous or the normal populations. On the contrary, factor VII cross-reacting material was normal. A good negative correlation was found between factor VII level and prothrombin times. All patients came from the same valley of northeastern Italy. This valley, the Piave river valley, is not far from the valley.where the factor X Friuli defect was found. The significance of this peculiar geographical distribution of the two abnormalities is unknown.
ISSN:0001-5792
DOI:10.1159/000206945
出版商:S. Karger AG
年代:1982
数据来源: Karger
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7. |
Effect of Glucocorticosteroids on Some Coagulation Tests |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 39-42
Kaj Anker Jørgensen,
Per Sørensen,
Leif Freund,
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摘要:
To investigate the influence of glucocorticosteroids on the coagulation system, some coagulation tests were performed before, after 2 days’ and after 6 weeks’ treatment with Prednisone® in 23 patients with collagen or hematological diseases. The prothrombin and proconvertin (P&P), plasma antithrombin III (AT-III), and factor VIII related antigen increased significantly, while the activated partial thromboplastin time (APTT), fibrinogen and plasminogen decreased significantly upon Prednisone treatment. Investigations on fibrinolysis were inconclu
ISSN:0001-5792
DOI:10.1159/000206946
出版商:S. Karger AG
年代:1982
数据来源: Karger
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8. |
Haemoglobin Disorders: A Pattern for Thalassaemia and Haemoglobinopathies in Arabia |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 43-51
M.A.F. El-Hazmi,
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摘要:
The mild course of the diseased state of haemoglobinopathies and the thalassaemias in Arabia and the interaction of the genetic abnormality and environmental factors are particularly interesting as the Peninsula exhibits a diverse climate and topography that encourages study of thei interactions between various genetic and environmental factors.The present study is aimed at elucidating the incidence and frequency of these genetic abnormalities in various regions of Saudi Arabia. The relationship between haemoglobinopathies, thalassaemia and glucose-6-phosphate dehydrogenase deficiency on the one hand and malaria parasites on the other are elucidated. The results are presented in the light of the environmental factors prevailing in the area.
ISSN:0001-5792
DOI:10.1159/000206947
出版商:S. Karger AG
年代:1982
数据来源: Karger
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9. |
Ultrastructural and Chromosomal Studies in a Patient with Hypergranular (M3) Promyelocytic Leukemia with Two Abnormal Clones |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 52-57
I. Zahavi,
F. Shabtai,
S. Appel,
C. Rudniki,
M. Djaldetti,
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摘要:
The internal and surface ultrastructural features of the white blood cells of a patient with hypergranular (M3) promyelocytic leukemia are described. Cytogenetical studies of the patient’s cells revealed the presence of two abnormal clones: the first, 45, XY, -7, and the second with an interstitial deletion in the long arm of chromosome 15 with break points at q22 and q2
ISSN:0001-5792
DOI:10.1159/000206948
出版商:S. Karger AG
年代:1982
数据来源: Karger
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10. |
Spontaneously Acquired Factor VIII Inhibitor in a 7-Year-Old Girl |
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Acta Haematologica,
Volume 68,
Issue 1,
1982,
Page 58-62
Koji Nakashima,
Taeko Miyahara,
Shinya Fujii,
Kohei Kaku,
Noboru Matsumoto,
Toshio Kaneko,
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摘要:
The youngest case with spontaneously acquired inhibitor to factor VIII is reported. A 7-year-old girl without any previous disorders presented with a hemarthrosis in the left knee and developed a rapidly expanding hematoma on the right arm, shoulder and chest after an initial infusion of factor VIII concentrate (1,000 units). Circulating anti-factor VIII antibody was detected. Her coagulopathy was successfully managed with an additional massive infusion of factor VIII concentrate (7,500 units) and combination therapy of prednisolone and cyclophosphamide.
ISSN:0001-5792
DOI:10.1159/000206949
出版商:S. Karger AG
年代:1982
数据来源: Karger
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