摘要:

A retrospective analysis was performed on 32 patients suffering from Hodgkin’s disease with bone marrow involvement treated between 1972 and 1976. After 6 courses of chemotherapy (MOPP for 25 patients), we observed 20 complete remissions (62.5%), 8 lymph node partial remissions (bone marrow sterilization but persistence of pathological lymph nodes) and 4 failures. Among the 28 complete or partial responders, 17 received maintenance chemotherapy alone, 9 were submitted to 40 Gy and 2 to 20 Gy irradiations. 15 patients died and 8 relapses occurred – all in previously involved lymph node areas. Survival of complete and partial responders is significantly different (p = 0.01) according to whether they received maintenance chemotherapy alone (34.5%) or irradiation (75.7%). Disease-free duration is also significantly different (p = 0.05) according to whether the patients received maintenance chemotherapy alone (42.1%) or 40 Gy irradiation (10

ISSN:0001-5792    

DOI:10.1159/000207125

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Experiments measuring the sensitivity of mouse bone marrow stem cells (CFU-S) and granulopoietic progenitor cells (CFU-C) to γ-rays and neutrons are described. Both populations are more sensitive to neutrons than to γ-rays, and in each case CFU-S are more sensitive than CFU-C. The CFU-C (but not CFU-S) show a biphasic dose-response curve to γ-rays, and the data suggest that 20–50% of CFU-C in normal mice are more resistant to γ-rays than the rest, possibly due to hypoxia. This difference between the two cell populations may be related to differences in spatial location in the bone marrow. The recovery of these cells following γ-rays is consistent with previous data which suggests that CFU-C are not self-maintaining, but require to be fed in from the stem

ISSN:0001-5792    

DOI:10.1159/000207126

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Chronic myelogenous leukaemia (CML) rarely occurs in children. This study, the only Indian one in which Philadelphia (Ph′) chromosome was studied, lasted over 10 years and comprises 7 cases of CML out of 88 leukaemias in infancy and childhood. In 5 of these 7 cases, Ph′ chromosome was studied and was found to be negative in all 5. The Indian and the Western literature is reviewed and the rarity of the disease emphasised along with the higher incidence among Indian children, compared to the W

ISSN:0001-5792    

DOI:10.1159/000207127

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The ability of human bone marrow cells to metabolise ethanol has been studied. After incubation of suspensions of bone marrow cells with [1–14C] ethanol (0.1 mg/ml) for 1.5 h, radioactivity was present in the evolved CO2 and in the cellular lipids. Only a part of the 14CO2 generated was dependent on the presence of contaminating blood cells in the marrow cell suspensions. These findings indicate that one or more cell types in the marrow are capable of oxidising ethanol to acetaldehyde and acetate. Our data raise the interesting possibility that the effects of chronic alcoholism on the bone marrow may not be caused by a direct action of ethanol, but may be related to some intracellular or extracellular changes resulting from the metabolism of ethanol within the marrow cells themselve

ISSN:0001-5792    

DOI:10.1159/000207128

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Iron overload is a constant and the most important complication in thalassemia. Serum ferritin concentration accurately reflects body iron stores. A total of 245 thalassemic patients aged 12–55 years were examined, 71 having Hb H disease and 174 β-thalassemia/ Hb E disease. The patients received minimal or no blood transfusions. 73 patients with β-thalassemia/Hb E were studied 1–28 years after splenectomy. The serum ferritin levels in both Hb H and β-thalassemia/Hb E patients were higher than normal. They were higher in β-thalassemia/Hb E than in Hb H disease. Most striking was the significantly higher serum ferritin levels in splenectomized patients with β-thalassemia/Hb E disease than in the non-splenectomized ones. This observation is compatible with previous observations that splenectomy in thalassemia is associated with increased iron deposition and increased transferrin iron saturation. The further increase in iron overload after splenectomy in thalassemia should be borne in mind in considering removal of th

ISSN:0001-5792    

DOI:10.1159/000207129

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In order to measure platelet-associated IgG (PAIgG), we devised a solidphase enzyme immunoassay employing a competitive binding of peroxidase-conjugated anti-IgG antiserum between platelets and polystyrene tubes coated with IgG. The amounts of peroxidase bound to the tubes were measured in a spectrophotometer by an enzymatic reaction. This method is highly sensitive, reproducible and can be carried out more simply. The PAIgG values of normal controls averaged 21.6 ± 6.6 (SD) ng/l0τ platelets. 27 (93%) of 29 patients with idiopathic thrombocytopenic purpura (ITP), who had a platelet count of less than 15×104/μl, had PAIgG values greater than those of controls by 2 SD and averaged 205.5 ± 323 ng. There was a significant inverse correlation between platelet count and PAIgG value of ITP patients. The PAIgG values of patients with aplastic anemia were within normal r

ISSN:0001-5792    

DOI:10.1159/000207130

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In 1969, Ogston et al. reported that the normal activation of fibrinolysis by surface contact requires, in addition to Hageman factor and plasminogen, a HF cofactor which is present in the euglobulin fraction and other factor(s) present in the supernatant. It has also been suggested that the glass-treated plasma is deficient in HF cofactor. In our laboratory the glass-treated plasma was found not to be deficient in HF or in a strepto-kinase-activated proactivator or m plasminogen. The glass-treated plasma was found deficient in prekallikrein in kininogen and in clotting factors XI, IX, VIII and V. The results presented indicate that HF cofactor activity is not different from that of kallikrein and that HF cofactor does not act as a plasminogen proactivator. Furthermore, the results indicate that the ‘other factors’ present in the supernatant are not involved in contact-activated fibrinoly

ISSN:0001-5792    

DOI:10.1159/000207131

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A case of fatal pulmonal infection with Mycobacterium intracellulare in a patient with hairy-cell leukaemia is reported. 2 years after diagnosis and splenectomy chronic fever and progressive infiltration of the superior lobe of the left lung developed. Direct microscopical examination of bronchial aspirate detected acid-fast bacilli. Despite vigorous treatment with antituberculosis drugs the patient died shortly after the diagnosis of the infection. The bacteria were post mortem classified as Mycobacterium intracellulare, belonging to Runyon group III. The role of monocytopenia and/or depressed monocyte function in hairy-cell leukaemia is discussed.

ISSN:0001-5792    

DOI:10.1159/000207132

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207133

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207134

出版商:S. Karger AG    

年代:1981

数据来源: Karger