摘要:

A trinitrophenyl derivative of urinary trypsin inhibitor (TNP-UTI) was found to demonstrate approximately 50 times stronger antiplasmin fibrinolysis than the intact UTI. Almost no change in antitrypsin or antichymotrypsin activity occurred as a result of the UTI modification. TNP-UTI was also shown to be a strong inhibitor of nonplasmin mediated fibrinolysis

ISSN:0001-5792    

DOI:10.1159/000205882

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Motility of leukemic cells was measured in a three-dimensional collagen matrix assay. Leukemic cells from 16 children with acute lymphoblastic leukemia (ALL) and normal peripheral blood lymphocytes (NPBL) from 6 healthy volunteers, were allowed to migrate into this collagen matrix for 48 h at 37 °C. NPBL migrated much further (300–600 μm) than leukemic cells (0–200 μm). Among the leukemic cases, only common ALL and one case of null ALL showed some migration (0–200 μm). T-All cells did not migrate at all under the circumstances of this

ISSN:0001-5792    

DOI:10.1159/000205883

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Intermediate dose intravenous melphalan at a dose of 15 mg/m2 × 4 given at 21-day intervals has been evaluated in 20 consecutive patients. The aims were to assess the time to obtain maximal response, duration of response and response to reintroduction of intravenous melphalan on relapse. Median time to maximal response was 17 weeks. Four patients achieved a complete response with complete disappearance of parapro-tein. On relapse, reintroduction of intravenous melphalan was unsuccessful in causing a reduction of parapro-tein, suggesting that resistance to this dose of melphalan occurs early even in responding patient

ISSN:0001-5792    

DOI:10.1159/000205884

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Simultaneous evaluation of bone marrow plasma cell thymidine labelling index (LI) and serum beta-2-microglobulin (SB2M) was performed in 146 patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance (MGUS). Eighty patients had MM on diagnosis, 11 were in relapse and 12 were in remission phase; 43 patients had MGUS. All the evalued patients had normal renal function with a creatinine level 2% at relapse of MM. SB2M correlated best with the stage of disease and tumor burden. These two factors therefore have different clinical utility: LI is a useful parameter to detect disease stability (e.g., MGUS) or highly proliferative disease (aggressive MM at diagnosis or early relapse). SB2M remains the best single predictor of patient tumor burden and associated survival durati

ISSN:0001-5792    

DOI:10.1159/000205885

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The in vitro immune functions of peripheral blood lymphocytes have been studied in 12 children with ^-thalassaemia major and hypersplenism. The study was performed prior to splenectomy and on the 2nd, 6th, 15th and 30th day after splenectomy. It was found that before splenectomy, patients had low numbers of blood leucocytes, normal rosette and T3 lymphocyte counts, low T4 and normal T8 lymphocyte counts with a T4/T8 ratio below 2, impaired T lymphocyte mitogenic responses induced by PHA, increased numbers of polyvalent and monovalent B lymphocytes and normal immunoglobulin levels of IgG and IgA. After splenectomy, especially on the 2nd day, leucocytosis, a significant decrease of T cells and their subsets and a reduction of the IgM levels were found. These parameters, except the IgM levels, increased until the 30th day after splenectomy and reached presplenectomy values. On the 2nd day after splenectomy, large mononuclear cells behaving like immunocytes appeared in the peripheral blood. They had the phenotype of T3, T4, T8, B lymphocytes and OKM1 monocytes. All the large mononuclear cells increased significantly on the 6th day after splenectomy and remained elevated during the whole study (30 days). The T4/T8 ratio was increased, but no increase was found in the functional responses of T lymphocytes

ISSN:0001-5792    

DOI:10.1159/000205886

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

We studied the prevalence of thalassemia trait in a group of Italian male myocardial infarction (MI) patients and an ethnically similar group of men admitted for other conditions. Italian men constituted approximately 13% of each group. Of 359 Italian men with a MI, only 2 had thalassemia trait. In contrast, of 330 adult Italian males in the non-MI group (mean age 59.6 years), 11 had thalassemia trait. Because the frequency of thalassemia trait was significantly (p < 0.01) lower in the myocardial infarct group, we conclude that thalassemia trait may be a protective attribute as regards MI. A prospective study of individuals with thalassemia minor is indicated to elucidate the mechanism for the observed protective effect and to determine what risk factors may offset the protective effect in those that do experience MI

ISSN:0001-5792    

DOI:10.1159/000205887

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Bone marrow biopsies from 30 alcohol-dependent individuals hospitalized for detoxification were investigated. Typical alcohol-induced bone marrow changes were found and served to define alcohol-induced bone marrow damage as a nosological entity. The findings took the form of heightened ineffective erythropoie-sis associated with impaired iron utilization, vacuolated proerythroblasts, multinuclear erythroblasts, megalo-blasts and iron-containing plasma cells as well as vacuolated precursor cells of the granulocytopoietic series. In the differential diagnosis, alcohol-induced bone marrow damage is to be distinguished from the myelodysplas-tic syndrome of the RA and RARS form. Alcohol-induced bone marrow damage is reversible. Bone marrow cell cultures performed in our cases are normal, showing that the toxic defect probably does not reside in the stem cell but is more peripheral. Normal bone marrow cell culture may be a typical feature of alcohol-induced bone marrow damage

ISSN:0001-5792    

DOI:10.1159/000205888

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A patient with acquired von Willebrand’s syndrome associated with polycythemia rubra vera is described. Ristocetin cofactor activity was decreased, while the levels of vWF:Ag and VIIL·C were normal. Crossed immunoelectrophoretic analysis showed that vWF: Ag was composed of much more anodic component. The mixture study using pooled normal plasma and the patient IgG fractions showed the inhibition of ristocetin cofactor and the decrease of less anodic parts of vWF: Ag in normal plasma. After l-deamino-8-argi-nine vasopressin (DDAVP) infusion the marked increases of vWF:Ag, VIII·C and ristocetin cofactor and a rapid return of ristocetin cofactor to the baseline were observed. Transient increase of vWF: Ag after DDAVP infusion showed less anodic forms and in the relative proportion as normal plasma. The present study showed that the patient IgG fractions had the specific inhibitory activity against the antigenic sites on the active sub-fractions of von Willebrand’s

ISSN:0001-5792    

DOI:10.1159/000205889

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000205890

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000205891

出版商:S. Karger AG    

年代:1987

数据来源: Karger