摘要:

Proliferation of blood leucocytes in cord blood and during the first 12 days of life was studied by autoradiography after a brief in vitro labelling with 3H-thymidine. Large numbers of labelled erythroid precursors were present in cord blood. During the first 3 days of life, the majority of labelled cells were immature myeloid cells. The percentage of labelled lymphoid cells rose more than tenfold 4-7 days after birth without any concomitant increase in the absolute numbers of blood lymphocytes. Most of the labelled lymphoblasts were able to form rosettes with sheep erythrocytes. Such a physiological neonatal lymphoblast response would appear to be a manifestation of cellular rather than humoral immunity and probably represents an immunological response to the antigenic challenge encountered after intrauterine life.

ISSN:0001-5792    

DOI:10.1159/000208173

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Lymphocytes obtained from fresh blood of patients suffering from chronic lymphatic leukemia have a lower intracellular potential than normal lymphocytes. Compared to normal lymphocytes, the intracellular potential in leukemic lymphocytes behaves differently in environments with a changing concentration of K and Cl ions.

ISSN:0001-5792    

DOI:10.1159/000208174

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The enzymes of blood and marrow neutrophils can be used to aid in the determination of the cell’s maturity. The enzyme marker which signals the production of secondary granules, leukocyte alkaline phosphatase (LAP), was found to be inactivated by aldehyde fixation, but minimal fixation of cells gave adequate marphological preservation and good enzyme activity. Notably, LAP activity was found to be present in neutrophils from the marrow myelocyte stage to the blood neutrophil stage, and high levels were found in the synthetic organelles of some circulating matureneutrophils. These observations at the electron microscopic level confirm the classical light microscopic histochemical finding

ISSN:0001-5792    

DOI:10.1159/000208175

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Eryhrocyte glucose-6-phosphate dehydrogenase (G-6-PD) of 370 randomly selected patients referred to the pediatric service of Pahlavi Medical Center, Tehran, was studied. A deficiency was found in 42.7%. Erythrocyte G-6-PD of the 58 subjects with normal level of the enzyme and 31 patients with deficiency had the electrophoretic mobility of variant B. Fast electrophoretic band (105-110% of normal) was present in 8 and slow mowing band (85-93% of normal) in 7 cases.

ISSN:0001-5792    

DOI:10.1159/000208176

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Following the demonstration of the ability of aqueous extracts of Fagara zanthoxyloides root to reverse sickling, toxicological studies in duck and chick embryos as well as in mice have shown these extracts to be non-toxic. Preliminary clinical trials demonstrated a significant diminution in the incidence of painful episodes in Fagara-treated individuals.

ISSN:0001-5792    

DOI:10.1159/000208177

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The in vitro effect of acetylsalicylic acid, phenylbutazone and indomethacin on the electrophoretic pattern of the red cell membrane proteins is described by using the vertical urea starch-gel electrophoresis. Normally 8 bands are visible. Acetylsalicylic acid and phenylbutazone bring about the disappearance of 5 bands and indomethacin that of 6 bands.

ISSN:0001-5792    

DOI:10.1159/000208178

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Adult albino rats were given intracardiac injections of copper sulphate, phenylhydrazine and antiserum to produce equivalent hemolysis. After 24, 48 and 72 h, 5 and 7 days the reticuloendothelial cells in the marginal zone of the spleen were studied. After copper sulphate these cells proliferate rapidly to form a band 8-10 layers wide after the 5th day. On the 7th day the perivascular lymphoid cells are almost completely replaced. Mitoses are prominent, and stem and plasmacytoid cells are formed as in an antigenic response. Phenylhydrazine and antiserum produced comparatively low proliferation. It is concluded that copper produces a prominent proliferative activity due to its stimulant action on cellular metabolism.

ISSN:0001-5792    

DOI:10.1159/000208179

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Three young unrelated propositi had β-thalassaemia trait (β-th-t) and chronic unconjugated hyperbilirubinaemia (UH). Red blood cell 51Cr t/2 was slightly reduced (from 19.0 to 22.8 days), liver function and histology, and iron metabolism included ferrokinetics and iron-chelation with Desferrioxamine B were normal. Bone marrow smears did not show features of dyserythropoiesis. Out of 20 relatives with normal liver function, β-th-t was present in 7, UH in 7, and β-th-t and UH in 3, while the remaining 3 subjects were normal. UH was chronic, benign, familial, without overt signs of haemolysis and with normal liver function, (and histology in 3 propositi); it was therefore of Gilbert’s type. Bromsulphophthalein kinetics and the reduced caloric intake test confirmed the diag

ISSN:0001-5792    

DOI:10.1159/000208180

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

After a 4 years’ course a granulocytic leukemia terminated as a Ê»microkaryoblastic leukemia’. Morphology and cytochemistry of the microkaryoblasts are desc

ISSN:0001-5792    

DOI:10.1159/000208181

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208182

出版商:S. Karger AG    

年代:1975

数据来源: Karger