摘要:

Lymphocytes forming spontaneous rosettes with sheep red blood cells (RFL) have been studied in normal individuals and patients with malignant lymphomas. Rosette formation was temperature dependent and was inhibited by sodium azide or trypsin treatment of -, but not by preincubation with an anti-hu- lymphocytes man immunoglobulin IgG preparation. In normals, 45–80% of peripheral blood lymphocytes formed rosettes, whereas patients with chronic lymphocytic leukemia and a patient with leukemic IgM-producing malignant lymphoma had an extremely reduced percentage of RFL (3–9%). In patients with Hodgkin’s disease, lymphocytic lymphosarcoma, ‘reticulum-cell sarcoma’, giant follicular lymphoma, Ig-producing lymphoma, and multiple myeloma, the proportion of RFL was either diminished or within the normal range

ISSN:0001-5792    

DOI:10.1159/000208278

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

In vitro blastic phytohaemagglutinin (PHA) transformation of blood and lymph node lymphocytes from cases of lymphadenitis, malignant lymphomas, and chronic lymphocytic leukaemia (CLL) has been studied. In lymphosarcoma and CLL the percentage of PHA-transformed lymph node lymphocytes was low, thus suggesting that such lymphocytes are of the B type. In Hodgkin’s disease, blood and lymph node lymphocytes gave PHA transformation nearly as high as in controls; this suggests that T lymphocytes are not necessarily involved in Hodgkin’s dise

ISSN:0001-5792    

DOI:10.1159/000208279

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Lymphocyte β-glucuronidase activity of 50 normal controls and of 101 patients with benign or malignant lymphatic processes, using Lorbacher’s technique, was studied. A constant and statistically significant decrease has been found in chronic lymphocytic leukaemia. This and other results are briefly discussed. The study of lymphocytic β-glucuronidase can provide useful information in the diagnosis of both peripheral and central lymphocyto

ISSN:0001-5792    

DOI:10.1159/000208280

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

In a study of 26 cases of myeloid splenomegaly with myelofibrosis, the authors find a large incidence of immunization anomalies, principally: positive latex reaction in 8 cases; monoclonal proteins in 3 cases; anti-erythrocyte antibodies in 6 cases. Anti-muscle antibodies, quantitative changes of the immunoglobulins and the presence of cryoglobulin are also observed. In a control group of 28 patients of identical age distribution, afflicted with various types of hemopathies, immunization anomalies are encountered far more rarely. The significance of immunization anomalies in the course of myeloid splenomegaly with myelosclerosis is discussed especially in its relationship with the development of medullary fibrosis.

ISSN:0001-5792    

DOI:10.1159/000208281

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The capacity of rat haemopoietic colony-forming units (CFU) to produce differentiated progeny has been investigated. The colony differential of primary colonies in the spleen was dependent on whether spleen or bone marrow was used as the l source of the CFU. However, both bone marrow and spleen derived colonies showed increases in the proportion of undifferentiated colonies and in the number of both surface and total colonies as the time of colony development was extended. On the other hand, the colony differential of primary colonies in the bone marrow was independent of the source of the CFU. Colonies in the bone marrow did not change in number or histological type as the period of colony development was extended. Since differentiation of CFU was more complete in the bone marrow compared to the spleen, it is suggested that the bone marrow in rats represents the better site to study stem cell differentiation. Calculations based on the results of individual colony transplant experiments suggest that approximately 30% of rat bone marrow CFU do not form colonies in the spleen because they differentiate.

ISSN:0001-5792    

DOI:10.1159/000208282

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The distribution of colony-forming cells in mouse bone marrow was studied using the modified exocolonizing test and the incorporation of 59Fe into spleens of recipient mice. It has been found that the colony-forming cells are distributed in the bone marrow of femora and lumbar vertebrae rather randomly and not accumulated near the endosteal surface and in the marrow of trabecular bone.

ISSN:0001-5792    

DOI:10.1159/000208283

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The case of a patient with infectious mononucleosis and acute myelocytic leukemia is presented. The course of the leukemia seems not to have been influenced beneficially by the infection. The total survival time was 11 months. The data of this patient are discussed in relation to those of other patients with concurrent infectious mononucleosis and acute leukemia, reported in the literature.

ISSN:0001-5792    

DOI:10.1159/000208284

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208285

出版商:S. Karger AG    

年代:1974

数据来源: Karger