摘要:

A 3-year-old child diagnosed as having acute lymphatic leukemia (ALL), developed meningeal leukemia 36 months after the onset of the disease. He was twice subjected to cranial irradiation plus intrathecal methotrexate (i.t. MTX). Skull radiology showed bilateral gyriform calcification of both cerebral hemispheres. Hematological relapse was first detected 5 years after diagnosis and the child died 5 months later. The most striking findings of a right frontal lobe biopsy and the postmortem examination were wide calcium deposits located in the cortex and in the adjacent white matter. Intense demyelination as well as areas of neuron poverty were apparent in the necropsy but not in the biopsy specimen. The possible interrelationship between such deposition and cranial irradiation and/or i.t. MTX suggests a new iatrogenic disorder.

ISSN:0001-5792    

DOI:10.1159/000207762

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

13 children affected by acute lymphoblastic leukemia in advanced stage of illness received a sequential therapy with daunorubicin and L-asparaginase. During daunorubicin therapy a significant decrease of bone hypercellularity as well as circulating cells occurred, a further cycle with a scarcely myelotoxic drug, L-asparaginase, was administered: a 10/13 (76.9%) remission of the disease was then achieved. This therapeutic trial was well accepted and could be more extensively used in the patients in relapse. A remission lasting between 4 and 28 weeks was observed.

ISSN:0001-5792    

DOI:10.1159/000207763

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Mixed-type cryoproteins, consisting of IgG and IgM, were demonstrated in the sera of four sisters. While the IgG component was polyclonal in every instance, in two of them the IgM component was found to be monoclonal with type κ light chains. Clinical diagnoses included the purpura-weakness-arthralgias syndrome, posthepatitis cirrhosis, congestive heart failure and mitral stenosis. The cryocrit differed in the four sisters, ranging from 3 to 16%; in addition, rheumatoid factor activity was consistently associated with both washed cryoprecipitates and their isolated IgM components. Endomembraneous deposits of IgG and IgM were revealed by immunofluorescent studies of the renal biopsy specimen from one patient. A genetic abnormality, possibly of the autosomal recessive type, is suggested in this instance of familial cryoglobulinemia

ISSN:0001-5792    

DOI:10.1159/000207764

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The erythropoietin responsive cells (ERC) in suspension cultures (ERCSC) of fetal mouse liver and the cells producing erythroid colonies in 2-day plasma clot cultures (CFU-E) sediment at similar rates. However, the sedimented fractions containing the majority of nucleated cells show minimal sensitivity to erythropoietin (Ep) and these cells sediment at a slower rate than the ERCSC. The studies suggest that in short-term suspension cultures of fetal mouse liver, Ep acts on morphologically unrecognizable cells to increase the number of hemoglobin-synthesizing cells rather than by increasing the quantity of hemoglobin synthesized per cell. This effect is similar to the principal in vivo action of Ep.

ISSN:0001-5792    

DOI:10.1159/000207765

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Aspirates from bone marrow, spleen and liver were analysed in 10 untreated patients with idiopathic myelofibrosis (MF). The proportion of erythroblasts was higher in the spleen and the liver than in the bone marrow. The mitotic indices of the erythropoietic precursor cells were subnormal in the extrameduUary sites and significantly lower in the liver compared with the spleen. There was a ‘shift to the left’ within the liver erythropoiesis and a significant megaloblastosis in the spleen. The same tendencies have formerly been found in patients with chronic myeloid leukemia and it is suggested that the discrepancies may be due to differences in the microenvironment of the erythropoietic ce

ISSN:0001-5792    

DOI:10.1159/000207766

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Arabs living near the Sea of Galilee were found to be homozygous for hemoglobin S. Studies of solubility, mechanical precipitability, electrophoretic mobility on starch-gel and citrate agar media, minimum gelling concentration, and peptide mapping of the hemoglobin β-chain confirmed complete identity of the hemoglobin with that found in Afro-American hemoglobin S homozygotes. A comparison of Arab Hb S homozygotes with Afro-American Hb S patients showed no significant differences in hemoglobin levels, red cell indices or morphology. Hb F averaged 4.4% in Arab patients. The 2,3 diphosphoglycerate levels were increased approximately twofold in Arabs, whereas in Afro-Americans, it was increased by only 7% in females and 20% in males

ISSN:0001-5792    

DOI:10.1159/000207767

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

This report describes an unusual case of Waldenström’s macroglobulinaemia, in which the sole demonstrable clinical manifestations were pleural effusion and ascites. Bone marrow aspirates and bone biopsy revealed no increase in lymphocytes. The case responded to a combination therapy of melphalan, cyclophosphamide and prednisolo

ISSN:0001-5792    

DOI:10.1159/000207768

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The clinical history of a 33-year-old man suffering from an autoerythrocyte sensitization syndrome due to hemoglobin sensitivity is presented.

ISSN:0001-5792    

DOI:10.1159/000207769

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207770

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207771

出版商:S. Karger AG    

年代:1978

数据来源: Karger