ISSN:0001-5792    

DOI:10.1159/000206187

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Prostaglandin E (PGE) production was evaluated in 18 normal subjects and 29 patients with Hodgkin’s and non-Hodgkin’s lymphomas. Plasma PGE levels of patients were found to be highly increased. Increased PGE synthesis was demonstrated in conditioned media from peripheral blood and bone marrow mononuclear cells, arising from the adherent cell fraction enriched in monocytes. No relationship with clinical or pathological findings was obse

ISSN:0001-5792    

DOI:10.1159/000206188

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

In recent years we have had the occasion to observe hyperthyroidism in 6 patients with Hodgkin’s disease. All patients had received Mantlefïeld irradiation and were disease-free when hyperthyroidism appeared. Hyperthyroidism allows three different pictures to be distinguished: 1 case report of Graves’ disease without ophthalmopathy, 1 case report of Hashimoto’s thyroiditis corresponding to a particular form called hashitoxicosis, and 4 case reports of atypical silent thyroiditis. Reports concerning case studies of postirradia-tion Graves’ disease or Hashimoto’s thyroiditis during Hodgkin’s disease are only to be found exceptionally. Atypical silent thyroiditis was recently individualized, but no postirradiation case studies have been reported. It is suggested that these 6 cases represent a radiation-induced immune thyroid disease: physiopathology and predisposing factors

ISSN:0001-5792    

DOI:10.1159/000206189

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Ten patients (9 adults, 1 child) with severe aplastic anaemia (SAA) were treated with anti-thymocyte globulin (ATG). All patients developed serum sickness. No long-term adverse sequelae attributable to ATG were noted. Fifty percent of patients are alive at 1 year post-ATG. One patient received an allogeneic bone marrow transplant because of failure to respond to ATG. One long-term survivor is severely thrombocyto-penic and requires support, and one patient has mild thrombocytopenia requiring oxymetholone therapy

ISSN:0001-5792    

DOI:10.1159/000206190

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Out of 60 patients with acute myeloid leukemia not preceded by chronic myelocytic leukemia or any preleukemic phase, 7 had both lymphoid and myeloid markers. All patients expressed common acute lymphatic leukemia antigen (CALLA) in 20% or more of their leukemic cells, which also showed positive peroxi-dase reaction. In addition, 4 patients had Auer rods. Two additional patients had morphologically clear acute monocytic leukemia (FAB M5b) and cells expressing CALLA. In 4 of the 7 patients the sum of the percentages of peroxidase or Leu Ml + and CALLA-positive blast cells exceeded 100%, suggesting that at least some of the cells had both myeloid and lymphoid markers. Moreover, out of 3 patients where double staining with the CALLA antibody J5 and the myeloid marker Leu M1 was performed, 2 had both markers on the same cells

ISSN:0001-5792    

DOI:10.1159/000206191

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Myeloperoxidase (MPO) activity was studied in adults with iron deficiency anemia (IDA) or anemia of chronic disorders (ACD). MPO activity (biochemical quantitation) was found to be decreased in IDA when compared to the control group (p 0.05). MPO scores (MPO staining) were significantly lower in IDA and ACD subjects than in the healthy control group (p < 0.05). A significant positive correlation was noted between ferritin (R = 0.40) and percent transferrin saturation (R = 0.37) and MPO activity (p < 0.001) in IDA and for the healthy controls

ISSN:0001-5792    

DOI:10.1159/000206193

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The influence of the α-thalassaemia gene on the haematological, biochemical and clinical presentation of sickle cell anaemia (SC A) was investigated in Saudi patients with 1 or 2 α-gene deletions. The results were compared to the results obtained in SCA patients without α-thalassaemia. In SCA patients with 2 gene deletions (homozygous α-thalassaemia 2), the mean cell volume, mean cell haemoglobin and Hb F were significantly lower (p < 0.05), while packed cell volume and Hb A2 level were considerably higher (p < 0.05) than in the SCA patients without α-thalassaemia. RBC and haemoglobin were higher in the former group, but the difference was not statistically significant. Patients with 1 gene deletion had intermediate values. Among the biochemical parameters, the bilirubin level was highest in patients with 1 gene deletion. Triglyceride, cholesterol, creatinine and urea levels were lower in all SCA patients, while alkaline phosphatase (ALP) and transaminases were elevated. The increase in the levels of ALP, SGOT and SGPT was maximum in the SCA patients with 2 gene deletions, but except for SGOT, the increase was not statistically significant. The retrospective analysis of the clinical data revealed that SCA patients with α-thalassaemia had fewer complications and had received fewer blood transfusions than the patients without α-thala

ISSN:0001-5792    

DOI:10.1159/000206194

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Isolated and washed cryoglobulins obtained from 30 patients with different diseases were studied for the presence of fibronectin by immunoelectrophoresis. Two of the isolated cryoglobulins were of the type I, 3 were of the type II, while the other 25 were of type III. Despite extensive washing, fibronectin was detected in all the cryoprecipitates. Our results indicate the constant presence of fibronectin in the cryoprecipitates from patients with different diseases and types of cryglobulin. The possible mechanisms by which fibronectin could act in the precipitation of immunoglobulins are discussed

ISSN:0001-5792    

DOI:10.1159/000206197

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

We describe a patient with hemophagocytic syndrome resembling malignant histiocytosis which was complicating myelodysplastic disease of 3 years duration. Detailed morphological and ultrastructural studies indicate that the histiocytic component did not demonstrate features of malignancy. A review of other known malignancies ending up in the hemophagocytic syndrome is given, and the significance of this syndrome is discussed

ISSN:0001-5792    

DOI:10.1159/000206198

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A 59-year-old woman was treated with surgery followed by monthly injections of the alkylating agent thiotepa for a granulosa cell tumor of the left ovary. Chemotherapy was continued for 22 years. At the age of 84, chronic myelogenous leukemia (CML) developed. Cytogenetic studies revealed incomplete trisomy of the long arm of chromosome No. 1 as the only karyotypic abnormality. No Philadelphia chromosome was detected. The significance of trisomy lq as an isolated cytogenetic abnormality in CML and the occurrence of CML following treatment of ovarian cancer are discussed

ISSN:0001-5792    

DOI:10.1159/000206200

出版商:S. Karger AG    

年代:1985

数据来源: Karger