摘要:

Characterization of C-type RNA viruses suggested that genetic and environmental factors are involved in the expression of the leukemia viruses. A reverse transcriptase in C-type viruses, in human and animal leukemic leukocytes provides a mechanism by which an RNA tumoral virus may transform permanently a normal cell. However, it has been found the presence of reverse transcriptase in normal and different hematological conditions. The study of the genome of human leukemic cells is also related with the characterization of satellite DNAs, which are families of nucleotide sequences having different repetition frequencies. Experimental evidence obtained in animals make it possible that satellite DNA might be a point of insertion of viral gene in the cell to be transformed.

ISSN:0001-5792    

DOI:10.1159/000208413

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In 7 cases of untreated and 2 cases of treated acute leukaemia (AL) the erythropoietic cell proliferation was studied by the combined method using AFeulgen-cytophotometry and autoradiography after labelling with 3H-TdR in vivo (1 h after intravenous injection) or in vitro. A proliferation disturbance was observed, which was almost limited to the early polychromatic erythroblasts, consisting of an accumulation of diploid and unlabelled cells and a decreased proportion of cells in S. This proliferation defect was not present during complete remission. The results indicate the existence of out-of-cycle cells (G0-cells) in the erythroblasts of AL, which may be responsible for ineffective erythropoiesis in this disease.

ISSN:0001-5792    

DOI:10.1159/000208414

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

With repeated intravenous administrations of DMBA transplantable myeloid rat leukaemia has been induced. In the course of transplantations 2 forms have developed: (1) the subacute form maintained with liver and spleen cell suspensions yielding a true leukaemic blood picture; (2) the acute ascitic form without leukaemic blood picture. The subacute form of leukaemia following serial transplantation has kept its original character.

ISSN:0001-5792    

DOI:10.1159/000208415

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A case report of a patient that developed acute myelomonocytic leukemia after Hodgkin’s disease, treated with total nodal irradiation, is presented. The relationships between Hodgkin’s disease and leukemia and in particular radiation leukemoge nesis are discussed and it is concluded that treatment with ionizing radiation is the single most important etiological fac

ISSN:0001-5792    

DOI:10.1159/000208416

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In a case of chronic myelogenous leukemia with an acquired sex chromosome mosaic (45, XO, PhV46, XY, Ph1), variant cells, developed after blast crisis, were evidenced to have been originated from a 46, XY, Ph1+ clone because of the constant presence of a Y chromosome in them. This strongly suggests that acute transformation has occurred selectively in a single clone.

ISSN:0001-5792    

DOI:10.1159/000208417

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The influence of the salts of saturated and non-saturated fatty acids from C8 to C22 on the aggregation of human platelets is compared within the framework of 2 different techniques: the test of filtration pressure, in correlation with the classical photometric test of aggregation. Thus, with the technique of filtration pressure of platelet-rich plasma, one finds an increase in filtration pressure as a function of the number of carbon molecules in the chain used. The presence of a double bond generally results in a decrease in filtration pressure. In the classical photometric test the fatty acids induce a progressive and irreversible deviation curve, demonstrating both the aggregation of platelets and the probable bonding of the fatty acids with plasmatic proteins. The presence and intensity of platelet aggregation are related to the molecular weight of the chain of fatty acids under consideration and inhibited by the presence of double bonds. From the similarity of the results obtained with the 2 techniques, one might surmise that the filtration pressure test is a new approach to platelet aggregation.

ISSN:0001-5792    

DOI:10.1159/000208418

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Following the failure to discover significant factor VIII and IX levels in a 14-week male fetus, from a pregnancy terminated because the mother was a known carrier of Christmas disease, these factors were measured in 10 other apparently normal fetuses. In no case was the level above 1%. Factors VIII and IX, therefore, do not to be synthesised in early pregnancy, so itis not possible to differentiate normal from haemophilia and Christmas disease males by present techniques during the early stages of pregnancy when termination would be acceptable.

ISSN:0001-5792    

DOI:10.1159/000208419

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208420

出版商:S. Karger AG    

年代:1973

数据来源: Karger