摘要:

Myelopoiesis has been studied using quantitative cytochemical, cytometric and autoradiographic techniques. The earlier speculation that normal small myelocytes were mainly in Gt and early S has been confirmed. The distribution of promyelocytes and myelocytes between the different stages of interphase was normal in β-thalassaemia major and acquired sideroblastic anaemia; the disturbance in cell proliferation in these disorders being confined to erythropoiesis. The mean labelling index of promyelocytes and myelocytes in patients with a reactive neutrophil leucocytosis was 15% higher than the mean for normal marrow, indicating a significant increase in proliferation. Myelocyte labelling indices above 50% were seen in megaloblastic haemopoiesis due to vitamin B12 and folate deficiency and were rarely encountered in other diseases

ISSN:0001-5792    

DOI:10.1159/000208574

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The main clinical and haematological features of the onset of the acute myeloblastic crisis in patients with chronic myeloid leukaemia are presented. The main haematological feature was a fall of Hb and haematocrit in 11, a fall of WBC in 6, a fall of platelets in 2, a rise of WBC in 3, a rise of myeloblasts in 5 and a rise of WBC and myeloblasts in 8 patients.

ISSN:0001-5792    

DOI:10.1159/000208575

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

In the treatment of acute leukaemia in 12 adult patients, an initial course of 6-mercaptopurine (6-MP) 500 mg/day for 5 days was given, later reducing the maintenance dosage to tolerance. A complete remission could not be achieved in any case, but a partial remission resulted in 50% of the cases. The median survival period was only 50 days. It is likely that the results of 6-PM treatment for acute leukaemia in adults cannot be improved by a higher dosage. As more effective combinations of drugs are now available for induction treatment of acute leukaemia, the role of 6-PM seems to be centred on the maintenance of the remissions.

ISSN:0001-5792    

DOI:10.1159/000208576

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The anemia in experimental cholestatic jaundice has been studies in rabbits. A decreased erythrocyte deformability has been found in bile duct ligated animals and failed to be traceable in sham-operated ones. The deteriorated deformability of the red cells in a first step is caused by the action of surface active substances and secondly by other factors as a possibly deranged cell metabolism. Both factors will deteriorate the flexibility and thus the erythrocyte life-span.

ISSN:0001-5792    

DOI:10.1159/000208577

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

A 43-year-old female, when subjected to splenectomy for obscure splenomegaly, gradually developed an increasing bleeding diathesis. About 20 months after splenectomy, her platelets numbered 1.3 millions/mm3 and showed complete absence of aggregation Tby ADP, epinephrine and nor epinephrine but a normal reaction towards collagen; the activity of platelet factor 3 was also poor. After an inadvertent overdosage of myelo-suppressive therapy she went into a thrombocytopenic phase but the platelets readily recovered to a normal number and function on steroid therapy. The patient has been maintaining a normal platelet status since December, 1969.

ISSN:0001-5792    

DOI:10.1159/000208578

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

After one or two days, blood loss causes thrombocytosis and in the serum of exsanguined experi- mental animals a thrombocytosis-producing factor ap- pears. Splenectomy, adrenalectomy and hypophysectomy do not suspend the appearance of the serum factor. After exsanguination following nephrectomy by 2–18 h, the serum factor inducing thrombocytosis does not appear, whereas animals with ureter ligation react like those not operated upon. During the phase of isolated thrombocytopenia produced by intravenous administration of thromboplastin, the serum of nephrectomized animals shows a thrombocytosis-producing activit

ISSN:0001-5792    

DOI:10.1159/000208579

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

A Sinhalese family with hereditary elliptocytosis is been described. Three of the members had thalassaemia trait and 2 had CDue chromosome. There was no abnormality due to the elliptocytosis nor to the presence of the thalassaemia trait. Both genes had not interacted. The osmotic fragility was markedly decreased in 2 members before and after incubation.Two members did not show any haptoglobin bands.

ISSN:0001-5792    

DOI:10.1159/000208580

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

A case of congenital factor V deficiency is presented. The proposita is a 40-year-old female who has a prolonged prothrombin time corrected by the addition of adsorbed plasma but not by the addition of normal serum, a prolonged partial thromboplastin time and an abnormal thromboplastin generation corrected by the substitution of the patient’s adsorbed plasma with adsorbed normal plasma. The factor V level in the patient’s plasma is 6% of normal. Bleeding tendency was mild. Menstruation was almost always normal. No hemarthrosis ever occurred. The patient’s mother and one of her siblings were considered to be heterozy

ISSN:0001-5792    

DOI:10.1159/000208581

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208582

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208583

出版商:S. Karger AG    

年代:1971

数据来源: Karger