摘要:

Untreated patients with acute granulocytic leukemia showed impairment of microbicidal activity and, in one, this was associated with myeloperoxidase deficiency and staphylococcal infection. In chronic granulocytic leukemia, there was no significant impairment of microbial killing. However, reduction in the capacity to reduce nitro-blue tetrazolium indicated some disturbance of neutrophil function in this disorder.

ISSN:0001-5792    

DOI:10.1159/000207920

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The ability of blood and bone marrow neutrophils to reduce nitroblue-tetrazolium both before and after stimulation with Escherichia cσli endotoxin was investigated. The polymorphonuclear cells of the bone marrow are less able to reduce the dye than blood cells. This difference is maintained after stimulation by endotoxin. Early forms of neutrophils (myelocytes and metamyelocytes) have some reducing ability but this is more marked after stimulation with endotoxin

ISSN:0001-5792    

DOI:10.1159/000207921

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Ten patients with Ph1 chromosome-positive chronic myelogenous leukemia entering the acute stage were divided hematologically into two different groups. One was characterized by a predominance of myeloblasts in marrow and was cytogenetic either by diploid or hypodiploid, whereas the other had generally low myeloblast counts without significant differences between the peripheral blood and the bone marrow, and was characterized by hyperdiploidy. It is suggested that an extramedullary acute transformation in the spleen occurs primarily in most cases of the latter group.

ISSN:0001-5792    

DOI:10.1159/000207922

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Residues 124 and 125 of the β-chain of human haemoglobin are prolyl-prolyl. In the δ-chain, one of these positions is occupied by a glutaminyl, and there has been uncertainty as to which of the two residues is the prolyl and which the glutaminyl. The sequence has now been established to be δ124 Pro – 125

ISSN:0001-5792    

DOI:10.1159/000207923

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

By means of ferrokinetic investigations three different stages of myelosclerosis can be defined: stage I with shortened plasma iron disappearance half-time, increased plasma iron turnover and normal activities in surface-scanning; stage II with ferrokinetically detectable extrameduUary erythropoiesis and normal utilisation of plasma iron; stage III with ineffective erythropoiesis. This classification seems to correlate better with the clinical course of the disease than the histological staging and, furthermore, seems to have some prognostic relevance.

ISSN:0001-5792    

DOI:10.1159/000207924

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Platelet and leukocyte counts and leukocytotoxic and platelet antibodies were studied in 32 patients with autoimmune hemolytic anemia (AHA). Leukopenia was present in 59.4%, thrombocytopenia in 59.4% and leukothrombo-cytopenia in 40.5% of the cases. Specific antibodies for granulocytes were found in 81.3%, platelet antibodies in 90.6%. The AHA, leukopenia and thrombocytopenia generally presented a dissociated evolution and a different response to immunosuppressive treatment. The leukopenia of 2 and the thrombocytopenia of 6 patients appeared at variable time intervals after the AHA or the detection of leukocyte and platelet antibodies. Thrombocytopenic purpura was present in 6 patients, and in 2 of these since infancy. AHA may thus be a complex autoimmune syndrome that may involve leukocytes and platelets as well as erythrocytes, with synthesis of autoantibodies specific for different blood cells.

ISSN:0001-5792    

DOI:10.1159/000207925

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In soft agar cultures of canine blood leukocytes, an inhibition of colony formation was observed relative to the size of the inoculum. Analysis of the cellular composition of the inoculum suggested that this inhibition was associated with the number of polymorphonuclear leukocytes present. Removal of phagocytic cells by the iron ingestion method or selective destruction of granulocytes by freezing in the presence of dimethyl sulfoxide eliminated the inhibitory action on colony formation. In mixed cultures of canine bone marrow and autologous blood leukocytes, a similar inhibition of colony formation was observed. The results presented indicate that polymorphonuclear leukocytes, if present in a concentration exceeding 2.5×106/ml of inoculum, inhibit in vitro granulocytic/monocytic colony formation

ISSN:0001-5792    

DOI:10.1159/000207926

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A new variant of glucose-6-phosphate dehydrogenase (G-6-PD) has been discovered in Northern Italy, in the district of Ferrara. This variant is characterized by high decrease of red blood cell enzyme activity (less than 5% of normal), high affinity for G-6-P and NADP, increased utilization of deamino-NADP and 2-deoxy-G-6-P, and faster electrophoretic mobility in the buffer systems commonly used for the classification of the G-6-PD variants. The new G-6-PD type was never associated with clinical manifestations in any cases except neonatal jaundice in some of the newborns with this enzyme deficiency. The frequency of the new variant in the Ferrara district indicates that it has probably appeared in this area by mutation some centuries ago. It is suggested that this variant should be named G-6-PD Ferrara.

ISSN:0001-5792    

DOI:10.1159/000207927

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In a patient with plasma cell leukemia, associated with pleural effusion, ultrastructural studies of the peripheral blood plasma cells showed an abundance of cytoplasmic fibrils. The nature of fibrils was not clarified, but they were not amyloid fibrils. This finding, coupled with a liaterature review, suggests that the cytoplasmic fibrils in plasma cells may be an additional cytological feature of this rare form of leukemia.

ISSN:0001-5792    

DOI:10.1159/000207928

出版商:S. Karger AG    

年代:1976

数据来源: Karger