摘要:

A case of systemic mastocytosis with unusual clinical manifestations, appearing as an isolated splenohepatomegaly, is described. The proliferative character is evident from the cytological characteristics of immaturity and the presence of a moderate percentage of mast cells in the peripheral blood. These cells make up 40%of the total cells in the bone marrow Special attention is given to the optical, morphological, cytochemical, and ultrastructural studies of the disease. Some anomalies were found at the subcellular level which apparently have not been recorded until present Various dyshematopoietic features of this case are reported, which may be considered as manifestations of a paraneoplastic syndrome

ISSN:0001-5792    

DOI:10.1159/000207846

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Bone marrow smears from 57 patients with chronic renal failure were morphologically analysed. In 55 patients on regular haemodialysis there was a slight ‘shift to the left’ and a significant eosinophilia within the granulopoiesis concurrently with slight megaloblastic changes of the erythroblasts. It is suggested that these abnormalities are caused by the dialysis procedure and not by the uraemia pe

ISSN:0001-5792    

DOI:10.1159/000207847

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The effect of conservative treatment of aplastic anaemia was evaluated retrospectively in 40 patients. No significant beneficial effect was provided by long-term high-dose oxymethalone in 20 patients or by metenolone, adrenostenolone, or testosterone in 14 patients. Splenectomy gave no improvement in the majority of cases, although in some it decreased the transfusion requirement. Immunosuppressive treatment was successful in 1 patient with a positive LE phenomenon. Until a specific treatment becomes available, the possibility offered by alternative treatment, e.g. bone marrow transplantation, in cases with poor prognostic parameters should be considered

ISSN:0001-5792    

DOI:10.1159/000207848

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The first case of Fletcher factor deficiency from the African continent is described. This was the only case of symptomatic Fletcher factor deficiency detected in a total population survey of 40,522 persons. This patient differs from other reported cases in that the child had symptoms of severe bleeding defect such as recurrent haemarthrosis and haematoma. The clinical features appear to improve with age. Both the PTT ‘time course’ and cold-induced EACA acceleration of the thromboplastin time are useful diagnostic tests for detecting homozygous patients. Our results confirm an earlier report that the EACA test is a sensitive test for detecting heterozyg

ISSN:0001-5792    

DOI:10.1159/000207849

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207850

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207851

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207852

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207845

出版商:S. Karger AG    

年代:1977

数据来源: Karger