摘要:

In comparison to other criteria of iron status, higher degrees of association have been computed between the diffuse Prussian blue reaction of the bone marrow macrophages and intestinal ferrous iron absorption, when test doses of 0.56 mg, 50 mg in solution, and 50 mg in quick-release capsules were given to fasting iron-replete controls and iron-deficient subjects in 59Fe absorption whole-body retention tests. The variability of the results increased with rise of the test doses. Antecedent oral iron substitution and unallowed intake of food depressed ferrous iron absorption considerably.

ISSN:0001-5792    

DOI:10.1159/000208395

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Haemophilic synovial membranes obtained by synovectomy have been histochemically studied for the locausation of plasminogen activator. In the two histological types of synovial membrane (vascular and fibrous type), different degrees of fibrinolysis were detected. Higher fibrinolytic activity was found in the vascular type of haemophilic synovial membrane as compared to the normal synovial tissues. Activity was low or absent in the synovial membrane undergoing a process of fibrosis. These results may help to explain the mechanism of bleeding in haemophilic joints.

ISSN:0001-5792    

DOI:10.1159/000208396

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The cerebrospinal fluid (CSF) of 22 consecutive untreated children with acute lymphocytic leukemia who entered total study VII from September to December 1971 at St. Jude Children’s Research Hospital was examined. Four patients had periodic acid-Schiff (PAS)-positive, Sudan black B- and peroxidase-negative lymphoblasts in the CSF at diagnosis. Two of the 4 developed meningeal leukemia 3 and 5 months following diagnosis. None revealed pleocytosis and/or detectable atypical cells on a Wright-stained smear of CSF sediment at diagnosis. Two patients had no more detectable PAS-positive lymphoblasts after ‘prophylactic’ central nervous system (CNS) radiotherapy. They are in continuous complete remission for 9 and 10 months. The recognition of a small number of CSF-abnormal cells with PAS reaction and the differentiation of blasts from inflammatory cells may allow an earlier diagnosis and treatment of CNS involvement in childhood acute lymphocytic leu

ISSN:0001-5792    

DOI:10.1159/000208404

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Muramidase, acid phosphatase and nonspecific esterase were investigated in mononuclear cells of skin window exudate in normal persons and patients with various forms of leukemia. While acid phosphatase and nonspecific esterase gradually increased, muramidase activity was reduced. Fifty hours after the onset of the experiment, most of the mononuclear cells were muramidase-negative. In monocytic leukemia, mononuclear cells appeared rapidly in the exudate. The ready liberation of muramidase may play a significant role for the increased muramidase in this type of leukemia.

ISSN:0001-5792    

DOI:10.1159/000208397

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The occurrence of a light chain related myeloma protein, which was defective compared with complete light chains, gave rise to further investigation of its structure. Mixing of 125I-labelled polypeptide chains resulting from the reduction of this protein with heavy and light polypeptide chains of an 131I-labelled myeloma protein showed recombination to a considerable extent. Fragments of L-chains, as it appears from these experiments, may exist as dimers stabilized by noncovalent bonds. Their interaction with light and heavy chains in vivo might compete with the normal assembly of immunoglobulin polypeptide chains.

ISSN:0001-5792    

DOI:10.1159/000208398

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The occurrence of multiple myeloma in mother and daughter is described. To the best of our knowledge, this has not been previously reported with both famismaly members available for detailed study.

ISSN:0001-5792    

DOI:10.1159/000208399

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A patient with chronic myeloid leukemia of 5 years duration developed myelofibrosis shortly before death. Severe destructive bone lesions were found preterminally in the femur, ribs, pelvis and skull. Hypercalcemia of 14.2 mg%was present as well. Although the serum calcium level was reduced by treatment to 11.5 mg%, the patient died in renal failure and pulmonary infection shortly thereafter. Hypercalcemia with its clinical implications should be suspected in the presence of myelofibrosis and bone pain complicating chronic myeloid leukemia.

ISSN:0001-5792    

DOI:10.1159/000208401

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208402

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208403

出版商:S. Karger AG    

年代:1973

数据来源: Karger