摘要:

A patient with Hodgkin’s disease is described, in whom thrombocytopenic purpura was the presenting manifestation of recurrence 15 years after the initial manifestation of the disease. Diverse factors involved in the mechanism of thrombocytopenia in Hodgkin’s disease are discu

ISSN:0001-5792    

DOI:10.1159/000207818

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Light and dark field autoradiography of semithin sections prepared 6h after a treatment with APS showed that the incorporation of H3 -leucine into the cells of the convoluted tubules of the kidney was increased in mice. There was no difference in the H3-leucine incorporation in the liver, either in thrombocytopenic or inuntreated animals. The increased incorporation of leucine in the kidney in APS-induced thrombocytopenia showed coincidence with increased thrombopoietin production

ISSN:0001-5792    

DOI:10.1159/000207819

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A comparison of the effects of progestogen-only and combined progestogen-oestrogen types of oral contraceptives on anti-thrombin III activity and fibrinolysis in African subjects in South Africa is reported. The changes in anti-thrombin III activity are similar to those reported in other races, but the augmentation of fibrinolytic activity is more marked than has been reported elsewhere. The possible significance of these findings is discussed

ISSN:0001-5792    

DOI:10.1159/000207820

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In hypochromic anaemias (heterozygous β-thalassaemia and iron deficiency anaemia) lighter red cells lose more K+ than heavier ones, following incubation at 37 °C for 24 h. Both in the light and heavy fractions two subpopulations of cells with different permeability to K+ can be separated by a new centrifugation after incubation. On the basis of the results, a relationship between K+ permeability and probability of survival in hypochromic cells is suggest

ISSN:0001-5792    

DOI:10.1159/000207821

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A study was carried out of 332 babies suffering from severe neonatal jaundice who were admitted to the General Hospital, Kuala Lumpur, Malaysia. Of the 332 neonates, 51 were premature and 281 were full-term babies, 178 (110 Chinese, 58 Malay, 9 Indian and 1 European-Pakistani) had bilirubin levels of 20 mg%or higher, requiring exchange blood transfusion. Of the Chinese neonates, 23 (20.9%) had G6PD deficiency, 9 (8.2%) had Hb Bart’s and 2 (1.8%) had an abnormal haemoglobin, one Hb Q and one fetal variant. Among the Malay infants, 10 (17.2%) had G6PD deficiency, 7 (12.1%) had Hb Bart’s and 10 (17.2%) had abnormal haemoglobins (four had Hb E trait, one had Hb K and Bart’s in addition to Hb E, three had Hb CoSp with Hb Bart’s, one had Hb Q and one Hb Tak). One of the nine Indian neonates had G6PD deficiency and one had Hb S trait. The one European-Pakistani baby was a carrier of Hb D Punjab. In addition to G6PD deficiency, abnormal haemoglobins seem to have contributed to the high incidence of severe neonatal jaundice in Malaysia. The mean activities of GP, GR and GR after stimulation with FAD were higher, while the mean activity of PK and mean level of reduced glutathione were lower than in normal cord bloods. The percent increase of GR after FAD stimulation was significantly lower; fewer in this group had increases above 20% than in normal cord blood. The possible significance of the findings is d

ISSN:0001-5792    

DOI:10.1159/000207822

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The proportions of mouse erythrocyte rosette-forming (MERF) lymphocytes, immunoglobulin (Ig)-bearing cells and E rosettes were examined in the peripheral blood of patients with lymphoproliferative diseases. The proportion of MERF lymphocytes was considerably increased in chronic lymphocytic leukaemia. The correlation between the proportions of MERF and Ig-bearing cells, characteristic of healthy individuals, is not observed in the lymphoproliferative diseases. It is suggested that in a part of the patients with these diseases, the study of the proportion of MERF cells provides more accurate information on the proportion of lymphocytes of bursal origin than does counting of the Ig-bearing cells

ISSN:0001-5792    

DOI:10.1159/000207823

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A case of atypical B cell dyscrasia is described. The patient presented with a history of weakness, bone pain, and bleeding. A K-type paraprotein was found in serum and urine. The histology of bone marrow was that of a malignant lymphoma, but no enlargement of peripheral lymphoid organs was detectable. Peripheral blood lymphocytes were increased in number and included two populations of immature cells, one lymphoid and the other lymphoplasmocytoid. Immunofluorescent staining showed both populations to contain K and γ chains in their cytoplasm. The clinicopathological heterogeneity suggests a malignant clone of B cells undergoing incomplete maturation, with arrest at different stages of the cell cycl

ISSN:0001-5792    

DOI:10.1159/000207824

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The ultrastructural features of the plasma cells of a 32-year-old patient suffering from multiple myeloma are described. The high percentage (90%) of plasma cells in the bone marrow aspirate permitted the examination of an almost homogenous population. The appearance of the plasma cells seen with the transmission electron microscope did not differ from that described in other reports. The surface architecture of the plasma cells, such as revealed by the scanning electron microscope, differed from that of the normal and pathological white blood cells. Of particular interest were the membrane-bound portions of the cytoplasm seen as ‘buddings’, or round bodies in the vicinity of the plasma cells which contained most probably pathological prot

ISSN:0001-5792    

DOI:10.1159/000207825

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The susceptibility to autoxidation of red cell lipids was studied before and after transformation of normal red cells to PNH-like erythrocytes. The transformation was effected by treatment of the red cells with the sulfydryl compounds D-penicillamine (DP) and N-acetyl-L-cysteine (NAC). The autoxidation was induced by incubating the cells with H2O2 and was estimated by measuring the generated malonyl dialdehyde. The susceptibility to autoxidation was significantly higher in DP-treated cells, while the opposite was true for NAC-treated cells. However, both DP- and NAC-treated cells showed a similar sensitivity to lysis by acid serum and about the same degree of acetylcholinesterase (AChE) activity decrease, thus indicating that the susceptibility to autoxidation of lipids is not involved in the determination of complement sensitivity or in the AChE activity decrease of the sulfydryltreated cells. Finally, since, as evidenced from most of the reported cases in the literature, increased susceptibility to autoxidation is a feature of PNH cells, it seems reasonable to suggest that DP-treated cells should be used in preference to NAC-treated cells as a laboratory substitute for PNH cells

ISSN:0001-5792    

DOI:10.1159/000207826

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207827

出版商:S. Karger AG    

年代:1977

数据来源: Karger