ISSN:0001-5792    

DOI:10.1159/000207618

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

20 out of 50 patients with well-functioning renal allograft displayed at least one platelet count below 110×109/1 (mean -2 SD of controls). For estimation of platelet production during thrombocytopenic episodes, the percentage of large platelets in the peripheral blood was determined which revealed an inverse relationship (p < 0.01) to the platelet count, indicating that these thrombocytopenias were due to increased platelet consumption. Immunosuppressive treatment as well as rejection processes could be excluded as major pathogenetic factors whereas anti-platelet autoantibodies may contribute to this phenomenon

ISSN:0001-5792    

DOI:10.1159/000207619

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In children with iron deficiency anemia, bactericidal capacity of polymorphonuclear leukocytes (PMN) and serum opsonic activity were studied. Nitroblue tetrazolium test (NBT), hexose monophosphate (HMP) shunt activation, and myeloperoxidase (MPO) activity of PMN of these cases were also examined. Bactericidal capacity and HMP shunt activation were found to be decreased in iron deficiency anemia (p > 0.001). MPO activity, NBT test, and serum opsonic activity were found to be within normal limits. After 11/2 months of iron therapy there was an improvement in bactericidal capacity and it returned to a normal level after 3 months of therapy.

ISSN:0001-5792    

DOI:10.1159/000207620

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The simplified Hb A2 determination based on microchromatography in Pasteur pipets filled with DEAE-cellulose with glycine-KCN-NaCl as developers [14] is compared with a reference Hb A2 determination procedure based on starch-block electrophoresis. The utility of microchromatography as a routine Hb A2 assay and as a screening method to detect β-thalassemia trait carriers and patients with iron deficiency anemia was investigated. Day-to-day variation of a control hemolysate and the correlation between the values obtained with the two methods and between determinations in duplicate on the same sample are given

ISSN:0001-5792    

DOI:10.1159/000207621

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A Basque Spanish family with heterozygous δβ-thalassemia is described. Patients with this anomaly usually present hematological findings observed in classical β-thalassemia, but clinical conditions and unbalanced chain synthesis are less severe. Our propositus, however, presented clinical and biosynthetic data similar to those described in thalassemia intermedia. A family study was also perform

ISSN:0001-5792    

DOI:10.1159/000207622

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The haematological indices of cord bloods from 430 South African Negro babies were determined by electronic cell counting and their haemoglobin (Hb) patterns examined by alkaline cellulose acetate electrophoresis. A fast-moving, anodal band, identified as Hb Bart’s, was found in 7 (l,6%) of the specimens, this being the lowest incidence of the variant yet found in an indigenous African population. The levels of Hb Bart’s ranged from 1.3 to 5.5% of the haemoglobin. These findings were confirmed by alkaline-starch gel electrophoresis and at the same time absence of the slow-moving haemoglobin, Hb Constant Spring was established. Subsequent follow-up of 4 of the infants at 4 months of postnatal life showed that the abnormal component had disappeared. The babies with Hb Bart’s had a marked microcytosis and low mean corpuscular haemoglobin levels whilst their parents showed no haematological or electrophoretic signs of α-thalassaemia. The significance of these findings is discussed in the light of previously reported studies on various Negro

ISSN:0001-5792    

DOI:10.1159/000207623

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

An abnormal, fast-moving haemoglobin was observed in 5 healthy subjects of a family from Calabria (southern Italy). In all these carriers the abnormal haemoglobin, which structural studies identified as Hb Norfolk (α257(E6) GIy→Aspβ2) [4], occurs at a level averaging 33% of the total haemoglobin. Biosynthetic studies showed no evidence for unbalance of the globin chain synthetic ratio. In order to account for the observed percentages of Hb Norfolk, current concepts about the α-globin chain genetic system are reviewed, and different genie arrangements which would be in agreement with the experimental findings are discu

ISSN:0001-5792    

DOI:10.1159/000207624

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

This paper presents data on the occurrence and pattern of inherited bleeding syndromes (IBS) in Jordan, a hitherto unexplored problem. In 1978, during the first 12 months of a prospective study at a major medical center, 91 patients from 51 families were diagnosed as having IBS. All patients were referred because of moderate-to-severe bleeding diatheses; they included 52 hemophiliacs, 27 patients with von Willebrand’s disease, 4 with hemophilia B (IX-deficit), 2 with afibrinogenemia, 1 with prothrombin deficiency, and 4 were thought to have platelet dysfunction. The clinical and laboratory features of the patients observed in Jordan do not seem to be significantly different from those of patients in Western Europe or North Americ

ISSN:0001-5792    

DOI:10.1159/000207625

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Amydopyrine is known to cause agranulocytosis by an immunological mechanism [2]. However, pancytopenia due to amydopyrine is extremely rare and usually mild and transient [3]. This report describes a patient with severe pancytopenia presumably due to amydopyrine sensitivity. Granulocytotoxic and lymphocytotoxic antibodies were detected in the patient’s serum using a 51Cr-release tes

ISSN:0001-5792    

DOI:10.1159/000207626

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A modified method of Cavill for the separation of the complex of isotopically labelled iron and transferrin from unbound iron residues is described. The method employing an ion exchanger permits to obtain preparations with a high radioactivity per volume unit of solution, which is necessary for carrying out ferrokinetic studies on small laboratory animals.

ISSN:0001-5792    

DOI:10.1159/000207627

出版商:S. Karger AG    

年代:1979

数据来源: Karger