摘要:

Cytochemical studies of various enzymes were carried out on megakaryocytes obtained from patients with disorders of megakaryocytes. In patients with idiopathic thrombocytopenic purpura megakaryocytes have uniformly low levels of the enzymes studied, as estimated by formazan deposition. In contrast, megakaryocytes obtained from patients with agnogenic myeloid metaplasia and especially essential thrombocythemia showed elevated enzymatic activities, particularly those of glycolytic enzymes such as lactic dehydrogenase. These findings presumably reflect the neoplastic nature of these myeloproliferative megakaryocytes.

ISSN:0001-5792    

DOI:10.1159/000208405

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In cultured human lymphoblasts methionine synthase(MS)-activity is enhanced during the logarithmic phase of population growth. MS is a ‘logphase enzyme’. Little activity is found in normal leukocytes and in cells of patients with chronic myelocytic leukemia. Acute myelocytic and lymphocytic leukemias show markedly enhanced values. Compared to thymidine kinase and DNA-polymerase, the very stable MS gives the same possibility to control the treatment of leukemic patie

ISSN:0001-5792    

DOI:10.1159/000208406

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In a series of 20 normal subjects, the δ-aminolaevulinic acid synthetase activity in liver homogenate has been assayed. The values ranged from 8.9 to 29.6 nmoles δ-aminolaevulinic acid/g liver/h; mean value 19.66±SD 6.64. The results are compared to those published by other authors using the same or other metho

ISSN:0001-5792    

DOI:10.1159/000208407

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The splenic pool size has been measured in 50 patients with splenomegaly due to myelo- and lympho-proliferative disorders. Splenic pool size was related primarily to spleen size and was not significantly influenced by the pathological disorder. Changes in spleen size due to treatment or progressive disease altered the pool size. The splenic pool could be discharged with adrenaline and noradrenaline.

ISSN:0001-5792    

DOI:10.1159/000208408

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In 74 adults with serum B12 Z. 140 pg/ml with or without anaemia, unsaturated B12-binding capacity (UBBC), total B12-binding capacity and transcobalamin I and II (TC I, TC II) were determined using 57Co B12. The results were statistically analysed in relatíon to severity of anaemia and vitamin B12 deficiency. In severe vitamin B12 deficiency, TC II was reduced and contributed to the reduction of UBBC. Greater unsaturation and moderate increase in total TC I were also seen. It is suggested that anaemia is a contributory factor in the moderate increase of TCI. On the basis of limited evidence presently available, it is argued that abnormal intestinal structure and function associ; ciency may result in impaired synthesis of TC II

ISSN:0001-5792    

DOI:10.1159/000208409

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Corticosteroid treatment of patients with hypereosinophilic syndromes resulted in dissolution of the granules in the blood eosinophil leukocytes. Although the mechanism of these changes and their consequences are not known, they may represent a preparatory step in which the granule components in the cellsto be marginated or removed from circulation are labilized.

ISSN:0001-5792    

DOI:10.1159/000208410

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

To investigate the anaemia found in chronic alcoholics with liver damage, model experiments in mice were performed, lasting from 5 weeks up to 1 year. Four groups were tested obtaining tapwater (controls), 100/o alcohol, tap-water containing small amounts of methotrexate, or methotrexate plus 10% alcohol in tap-water. Alcohol or methotrexate alone induced no haematological changes. When combining both agents, heavy anaemia developed, indicating a synergistic effect of alcohol and folic acid deficiency. Only minimal changes could be observed in the livers of animals receiving alcohol or alcohol plus methotrexate, respectively.

ISSN:0001-5792    

DOI:10.1159/000208411

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208412

出版商:S. Karger AG    

年代:1973

数据来源: Karger