摘要:

104 patients with various cancers, excluding malignant lymphoma and leukemia, underwent bone marrow biopsy using a Jamshidi needle, regular type. In 100 patients an adequate piece of bone marrow was obtained. In 24 patients metastases were detected in the bone marrow. Metastases were found in 10 of 38 (26.3%) patients with breast cancer, in 5 of 17 (29.4%) patients with lung cancer, in 5 of 10 (50%) patients with cancer of the prostate, in 1 patient with rhabdomyosarcoma, 1 with chordoma and in 2 of 14 patients who underwent biopsy in search of unknown cancer. 71% of the patients with positive findings in the bone marrow had clinical signs of bone involvement, 80% had positive X-ray film and 78.9% had positive skeletal isotope survey. Hemogram, serum alkaline phosphatase, serum calcium level and sedimentation rate were of no value in predicting whether the marrow was involved or not. No complications were documented following biopsy. The use of the Jamshidi bone marrow biopsy needle for staging and early detection of metastases in a select group of cancer patients is suggested.

ISSN:0001-5792    

DOI:10.1159/000207569

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A study of E-rosette ultrathin sections has been undertaken in an attempt to analyze changes induced during the T-lymphocyte-sheep red blood cell interaction on the rosetted lymphocyte surface architecture.The formation of nonimmune rosettes implies different types of attachment between lymphocytes and sheep red blood cells which can affect the rosetted lymphocyte surface morphology: (a) Junctions not involving morphological changes which correspond to bands or point-to-point contact sites, (b) Junctions displaying localized morphological changes, which are revealed mainly in the form of microvilli or digitations. (c) Junctions involving broad morphological changes, revealed primarily by the development of various microvilli or other more complex structures. In both cases, the alterations are found only in those areas of the lymphocyte membrane-bound sheep red blood cells. The modifications that affect the rosetted lymphocyte make the validity of the E-rosette test questionable for studies aiming at the analysis of the lymphocyte surface architecture.

ISSN:0001-5792    

DOI:10.1159/000207570

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The ability of neutrophils from patients with hairy-cell leukaemia to kill Candida guilliermondii and Staphylococcus aureus in vitro was investigated. Of 10 patients, 8 showed defective Candida killing, 5 defective bacteria killing, in comparison with normal controls. Study of those patients who underwent splenectomy suggests that neutrophil function can be improved by splenectomy. The possible causes of defective function in this disease are discussed.

ISSN:0001-5792    

DOI:10.1159/000207571

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Terminal deoxynucleotidyl transferase (TdT) determinations were carried out on peripheral blood leukocytes or bone marrow cells from 61 adult patients with various types of leukemia. TdT activity was undetectable in the cells of patients with acute myeloeytic or acute myelomonocytic leukemia but was present in 12 of 13 patients with acute nonmyelocytic leukemia. None of 3 patients with acute myelocytic transformation of chronic myelocytic leukemia (CML) manifested TdT activity while 4 of 6 patients with lymphoid transformation had such activity.More patients with TdT in their leukemic cells responded to treatment than those without TdT activity. However, our findings suggest that TdT activity may be less useful in management of leukemia than has sometimes been supposed.

ISSN:0001-5792    

DOI:10.1159/000207572

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A case of a 37-year-old woman presenting with acute agnogenic myeloid metaplasia (AAMM) is described. The disease had a stormy course and was characterized by moderate splenomegaly, persistently depressed WBC counts, extramedullary hemopoiesis and presence of a high percentage of atypical myeloblasts in the peripheral smear. Platelets were persistently low, reticulocytes significantly below normal, notwithstanding anemia. Hct tended to fall progressively to intolerably low values in the absence of transfusion.The chromosomal mapping of peripheral blood revealed the presence of a trisomy of chromosome No. 8. This abnormality already demonstrated in two previous cases of acute myelofibrosis and the clinical course of the disease suggest that acute myelofibrosis and AAMM could be the same disease while chronic myelofibrosis should be considered a separate entity. Also, it is possible that AAMM with trisomy of chromosome No. 8 and stormy clinical course may be a different entity from the acute myeloproliferative disorders associated with other chromosomal abnormalities.

ISSN:0001-5792    

DOI:10.1159/000207573

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

This is the first report of a case of chronic myeloid leukaemia (CML) complicated by myasthenic syndrome. The patient suffered two prolonged periods of idiosyncratic busulphan-induced marrow aplasia, the first occurring 5 months after busulphan was stopped. Between these two episodes, and at a time when no therapy was required for the leukaemia, myasthenic syndrome developed. After the patient recovered from the second episode, the myasthenic syndrome disappeared, and, despite subsequent recrudescence of CML, there were no further myasthenic symptoms, and treatment with neostigmine was discontinued.

ISSN:0001-5792    

DOI:10.1159/000207574

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Plasma β-Thromboglobulin levels were determined in 22 multiple myeloma patients, in 15 patients with polycythaemia vera and in 70 healthy controls. In both multiple myeloma and polycythaemia vera significantly increased plasma concentrations of this platelet-specific protein were found

ISSN:0001-5792    

DOI:10.1159/000207575

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

6 patients with polycythaemia vera who also developed concomitant iron deficiency are reported. When oral iron therapy was given, there was a marked reduction in the previously elevated platelet counts in 4 patients; during 2–9 years of observation of these patients there was a significant inverse relationship between haemoglobin concentration and platelet count. In the other 2 patients the elevated platelet counts did not fall when iron therapy was given. The significance of these different patterns of response in relation to the causal mechanism of elevated platelet counts in patients with polycythaemia vera is discusse

ISSN:0001-5792    

DOI:10.1159/000207576

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A radioimmunoassay for measuring levels of lymphocyte autoantibody in chronic lymphocytic leukaemia (CLL) has been developed. Antibody in the form of crude IgG was extracted from patients’ sera and iodinated. The assay utilizes its cross-reactivity with other CLL cells. Levels were measured in 23 patients. The results show that an inverse relationship exists between the quantity of circulating CLL autoantibodies and the number of mouse red blood cell rosetting lymphocytes (M cells). The preliminary findings do not correlate with disease activity although it is our impression that patients who are maintaining higher levels of autoantibody and fewer M-rosetting cells have non-progressive diseas

ISSN:0001-5792    

DOI:10.1159/000207577

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The value of serum ferritin and mean corpuscular volume (MCV) measurement in distinguishing between iron deficient, β -thalassaemia trait and normal subjects has been studied. Normal subjects had normal ferritin and MCV, iron-deficient ones had low ferritin and low or normal MCV, and thalassaemics had normal ferritin and low MCV. By the combined use of these two measurements it was possible to identify individuals belonging to one of the three categories with an accuracy of over 95%. Although definitive diagnosis of β-thalassaemia trait requires the demonstration of abnormal haemoglobin A2 levels or reduced β-ehain synthesis, serum ferritin and MCV measurements are useful screening procedures for the initial diagnosis of β-thalassaemia trait and iron deficiency. Because of the very small amounts of blood required for both of these measurements, they are particularly suitable for surveying large numbers of subjects in populations with a high prevalence of hypochromic-microcytic anaem

ISSN:0001-5792    

DOI:10.1159/000207578

出版商:S. Karger AG    

年代:1979

数据来源: Karger