摘要:

The results obtained by chemo + radiotherapy in 100 patients with Hodgkin’s disease at stage I or II as defined by clinical and radiological staging are analysed. All patients were treated by chemotherapy followed by radiotherapy; 74 received a complement chemotherapy after the radiotherapy. Statistical analysis emphasizes the usefulness of associating two cycles of chemotherapy with the classical radiotherapy. With this treatment which gives a constant remission rate of about 90% a long-term chemotherapy is no longer necessary and the interest of exploratory laparotomy becomes negligibl

ISSN:0001-5792    

DOI:10.1159/000208024

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The anemia of dialyzed uremic patients is due to several factors: loss of blood and proteins; increased destruction of erythrocytes, and alteration of erythropoietin feedback. In an anemic dialyzed patient the number of reticulocytes is normal while a sudden worsening of the anemia is followed by severe reticulocytosis.

ISSN:0001-5792    

DOI:10.1159/000208025

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Aspirates from bone marrow, spleen and liver were morphologically analysed in 15 untreated patients with chronic myeloid leukaemia. Megaloblastic changes of the erythroblasts were found to be more common in the spleen and liver than in the bone marrow. A significant increase of ‘erythroblastic islands’, i.e. erythroblasts in contact with reticulum cells, were recorded in the leukaemia patients compared to 15 healthy controls. It is suggested that the presence of such formations may indicate an increased death rate of defective erythroblasts followed by phagocytosis into reticuloendothelial ce

ISSN:0001-5792    

DOI:10.1159/000208026

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The possibility that oxymetholone might induce or enhance leukemia after androgen therapy for aplastic anemia prompted us to study the direct action of oxymetholone on the DNA synthesis of AML cells in vitro. The peripheral blasts of 10 patients, 8 with AML and 2 with CML in blast crisis have been studied. The DNA synthesis of the leukemic cells with and without oxymetholone was measured by the 3H-methyl-thymidine incorporation determined by liquid scintillation. The results have shown a wide variation of DNA synthesis from patient to patient with a range from 2,000 to 40,000 cpm but no significant difference between test and control cultures. We may conclude that oxymetholone does not increase directly the proliferation capacity of the peripheral AML cells cultured in vitro.

ISSN:0001-5792    

DOI:10.1159/000208027

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Red cell membrane glycopeptides of subjects suffering from different hematological disorders (PNH, hemolytic anemias, dyserythropoietic anemias and polycythemia vera) have been characterized. In most cases, except in polycythemia vera, a decrease of sialic acid and galactosamine was detected. The role of these alterations is discussed with regard to the decrease of membrane glycopeptides during, physiological aging of the red cell.

ISSN:0001-5792    

DOI:10.1159/000208028

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Human lysozyme in physiologic concentrations (10–400 μg/ml) significantly (p < 0.001) stimulates the phagocytosis of yeast cells by human polymorphonuclear leukocytes. This stimulating effect was observed even in the absence of serum factors. Hen egg white lysozyme or protamine sulfate had no effect on phagocytosis. The stimulating effect of human lysozyme was not the result of opsonization but was apparently related to the effects on constituent membranes of the phagocytic cel

ISSN:0001-5792    

DOI:10.1159/000208029

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Salicylamide-glucuronide formation has been determined in 27 children who underwent a favism crisis, 25 parents, and in 25 normal children who served as controls. A highly significant mean lower glucuronide formation was observed in the favism group in respect to the controls. The difference between fabic children and their parents was significant, and between parents and controls there was no significant difference.

ISSN:0001-5792    

DOI:10.1159/000208030

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Blood group phenotypes of anthropologic significance are described for inhabitants of two Israeli Arab communities with foci of hemoglobin S (HbS). The presence of Fy(a-b-), Rh0, hrV+, and Js(a+) among the Hulah Valley Bedouin, and of Fy(a-b-), Rh0, and hrV+ in Acre are indicative of genetic admixture of African origin. These non-African foci of HbS are thereby distinguished from previously described HbS foci in India, Greece, and Turkey where low or absent Rh0 phenotypes imply secondary dispersions of the HbS gene from the Arabian peninsula.

ISSN:0001-5792    

DOI:10.1159/000208031

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Increased plasma erythropoietin (ESF) activity, a rise in RBC 2,3-DPG, and a ‘right shift’ of the oxygen hemoglobin equilibrium curve following androgen administration to mice in ambient or hyperoxic conditions, was demonstrated. If androgens had a direct effect on the RBC metabolism, increased 2,3-DPG would result in a facilitated release of oxygen to the tissue. This would have been accompanied by a decrease rather than an increase in the level of ESF. Hyperoxia has abolished detectable rising levels of plasma ESF and RBC 2,3-DPG following androgen administration. These levels were close to those seen in the ambient nontreated m

ISSN:0001-5792    

DOI:10.1159/000208032

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Haemoglobin Belfast was initially observed in an Irish patient. The second case, found in a French patient suffering from a metastatic carcinoma, is here described. Both observations are compared from clinical, haematological and biochemical points of view. Functional and spectrophotometrical studies confirmed the slight abnormalities already described.

ISSN:0001-5792    

DOI:10.1159/000208033

出版商:S. Karger AG    

年代:1976

数据来源: Karger