摘要:

The ability of human bone marrow particles to produce a microenvironment conducive to granulocytopoiesis was tested by culturing them in vitro without an exogenous source of colony stimulating activity (CSA). Granulocytopoiesis in this system was confirmed by the following observations: (1) presence of mitotic figures in promyelocytes and myelocytes; (2) early disappearance of mature granulocytes, followed by their reemergence after 4 days in culture, and (3) presence of immature granulocytes even after 10–14 days in culture. Although no exogenous source of CSA was added to the culture plates, a probable endogenous source was the dense accumulation of stromal elements in the core of particles; these cells may generate sufficiently high local levels of CSA to stimulate and nurture granulocyte proliferation and maturati

ISSN:0001-5792    

DOI:10.1159/000207809

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Viable T lymphocytes stimulate the proliferation of human syngeneic hemopoietic stem cells, but not influence their differentiation. The biological significance of this activity is discussed and its possible physiological role in the regulation of hemopoiesis is considered

ISSN:0001-5792    

DOI:10.1159/000207810

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Clots obtained from normal native platelet-poor plasma are dispersed by the addition of 5 m urea. Clots from plasma diluted > 1/4 and clots from undiluted plasma, thoroughly washed, are not dispersed by urea, but are rendered susceptible to its dispersing action by prior incubation in normal undiluted plasma or serum. The same phenomenon was observed by incubating the otherwise unsoluble clots in normal plasma or serum fractions precipitated at 33% saturation with (NH4)2SO4. The serum fraction does not interfere with the incorporation of putrescine into casein, although it conditions the urea-dispersing action on stable clots

ISSN:0001-5792    

DOI:10.1159/000207811

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

It was demonstrated that washed human platelets can bind minute amounts of 14C-DNA on their surface during short-term incubation. The binding was specific and firm in the described experimental conditions. Washed platelets bound also 14C-DNA anti-DNA antibody complexes, although to a lesser amount than 14C-DNA alone. The possible significance of these findings is briefly discussed

ISSN:0001-5792    

DOI:10.1159/000207812

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

An acute oral administration of 50 mg metoprolol (a selective β-1-receptor antagonist) to 18 healthy volunteers induced a significant increase in the peripheral platelet concentration lasting more than 4 h. It is suggested that this increment in the platelet count originates from the exchangeable splenic platelet pool. The mechanism by which metoprolol exerts its effect remains to be establishe

ISSN:0001-5792    

DOI:10.1159/000207813

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A 53-year-old woman with a history of recurrent bleeding complications since childhood and a positive family bleeding history, previously diagnosed as von WiUebrand’s disease, was investigated. She was found to have a markedly reduced level of antihemophilic factor (AHF) activity, a low AHF activity/AHF antigen ratio, normal Ristocetin-induced platelet aggregation and a normal level of von Willebrand factor activity. These findings were consistent with the diagnosis of classic hemophilia A which was confirmed by the results of similar studies in nine of the patient’s relatives. The report illustrates the usefulness of newer laboratory methods in the differentiation between classic hemophilia A and von Willebrand’s disease which may have important clinical implic

ISSN:0001-5792    

DOI:10.1159/000207814

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Nonspecific esterase activity using α-naphthyl butyrate as substrate was found to be present in hairy cells from patients with hairy cell leukemia. Activity of this enzyme was markedly diminished and in some instances obliterated by sodium fluoride. Since α-naphthyl butyrate is believed to be a more specific substrate for monocytic-type nonspecific esterase than α-naphthyl acetate, its presence in hairy cells combined with fluoride inhibition which is also characteristic of monocytic nonspecific esterase provides additional evidence of monocytic properties of hairy ce

ISSN:0001-5792    

DOI:10.1159/000207815

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Acute promyelocytic leukemia (APL) was diagnosed in 13 of 84 adult patients (15.4%) with acute myeloid leukemia (AML) first admitted between 1972 and 1976. All patients had clinical and/or laboratory evidence of defibrination syndrome. Four patients died of cerebral hemorrhage within 2 days of admission. Two patients died of generalized infection on days 7, and 16, respectively, after admission. The remaining 7 patients (54%) underwent complete remission (CR) with daunomycin, arabinosyl cytosine, and adriamycin. All patients received massive platelet transfusion, no heparin, and no granulocyte transfusion. CR was more frequent in patients with a very low blast cell count and a fibrinogen level higher than 100 mg/ 100 ml. Median survival of these seven CR patients with APL is similar (15 months) to that of CR patients with other types of AML treated at the same institution during the same period

ISSN:0001-5792    

DOI:10.1159/000207816

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A patient with multiple myeloma (MM) who developed Kaposi sarcoma (KS) is described. The KS appeared 18 months after the diagnosis of MM and 1 month after the treatment was changed from cyclophosphamide to melphalan. The treatment with melphalan was discontinued and the spread of the KS was arrested by irradiation and bleomycin. One month after the melphalan was restarted, the KS advanced. The patient died 28 months after the diagnosis of MM and 10 months after KS had developed.

ISSN:0001-5792    

DOI:10.1159/000207817

出版商:S. Karger AG    

年代:1977

数据来源: Karger