摘要:

The serum levels of haptoglobin (Hp) and hemopexin (Hx) have been investigated in favism and thalassemia. In 25 children with favism, Hp was absent in 22 and both Hp and Hx in 7 cases. In 45 children with Cooley’s anemia, Hp was absent in 13 and Hx in 37 cases. In 25 adult carriers of thalassemia minor, the findings were similar to those observed in healthy controls. The absence of Hx in spite of moderate hemolysis in most cases of Cooley’s anemia is emphasi

ISSN:0001-5792    

DOI:10.1159/000208222

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The haematological effects of the economically important alkylphosphates, trichlorophone and dimethoate, were tested experimentally on rats. A pronounced haematotoxic action of these pesticidal organophosphate compounds was found, including severe hyperplasia of the haematopoietic parenchyma of bone marrow and extra-osseous myeloid metaplasia, particularly in liver and spleen. The interpretation of the results in terms of a myeloproliferation (panmyelosis) and myeloid leukosis and their practical implications are discussed.

ISSN:0001-5792    

DOI:10.1159/000208223

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The number of circulating platelets gradually increases in splenectomized mice exceeding the starting level of 50% during the second week. Nearly identical amounts of 75Se-methionine given at different times after splenectomy, or in the control group after sham-operation, appear in the circulating platelets of both experimental groups of mice. It is unlikely that increased platelet production could play a decisive role in the development of post-splenectomy thrombocytosis.

ISSN:0001-5792    

DOI:10.1159/000208224

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A continuous cell culture was established from unstimulated peripheral blood lymphocytes of a patient with chronic lymphocytic leukemia. The cells grew singly and in free-floating aggregates, and the population was mixed and contained lymphoid, plasmacytoid, reticulum cells, and blast cells. HL-A typing of the established cell line was identical to the preculture cells, and remained unaltered. Electron microscopy demonstrated HLV particles. Although aneuploidy was present, the predominant chromosomal mode was 46, male. Glycolytic enzyme patterns showed predominance of the enzymes utilized in the anaerobic pathway. The cell generation time was found to be 30–50

ISSN:0001-5792    

DOI:10.1159/000208225

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A case suffering from a so-called pure monocytic leukemia displayed excessive monocytic hyperproliferation, moderate histiocytic infiltrations in lymph nodes and liver, hyperproliferation of plasma cells and monoclonal hypergammaglobulinemia of the IgG type. Monocytic cells proved to be normal with respect to morphology including electron microscopy, cytochemistry, capacity of phagocytosis, motility and differentiation potential. An increased fraction of immature monocytic cells gained access to the blood. The immature cells being able to egress from the marrow proved incapable to leave the microcirculation. They continued to circulate until completion of differentiation to mature monocytes which finally developed a normal emigration potential.

ISSN:0001-5792    

DOI:10.1159/000208226

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A case of λ-type IgG myeloma with serum hyperviscosity, a strong positive Sia test, and few clinical manifestations is described. As the M-component concentration is not excessively high, after study by thin-layer chromatography these phenomena are attributed to the molecular shape and probably (although to a lesser degree) to M-component aggregation

ISSN:0001-5792    

DOI:10.1159/000208227

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The diagnosis of spontaneous haemophilia A with severe antihaemophilic globulin deficiency (less than 1%) was established in an 11-year-old girl with a normal female chromosomal pattern. Coagulation studies proved that the proposita is the offspring of a normal father with negative history for bleeding disorders and a normal mother who had an antihaemophilic globulin concentration of 200%. Family history revealed no bleeding disorder in 3 successive generations of the maternal side. This together with AHF activity exceeding slightly AHF-like antigen concentration provides good evidence against the carrier state of the mother. The possible mechanisms through which spontaneous haemophilia may occur in a genotypically normal female are discussed.

ISSN:0001-5792    

DOI:10.1159/000208228

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A case of disseminated intravascular coagulation (DIC) during a fatal Mycoplasma pneumoniae infection is reported. The results of several laboratory investigations suggested the presence of an autoimmune abnormality. Recurrence of DIC in the final period may have been due to circulating complement activating immune complexes.

ISSN:0001-5792    

DOI:10.1159/000208229

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208230

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208231

出版商:S. Karger AG    

年代:1974

数据来源: Karger