摘要:

45 patients with hypoproliferative or aregenerative anaemia were treated with oxymetholone, steroid an anabolic, androgenic steroid. Minimum treatment time accepted for entrance into the study was 3 months. Therapeutic effect was assessed by effect on bone marrow cellularity, haemoglobin concentration and granulocyte and platelet counts. Patients with a hypocellular marrow responded best. Of 18 cases, a partial remission was seen in 8 and a complete remission in 5. A complete remission was only seen in patients who did not have pancytopenia. Of the 7 patients with myelofibrosis, 4 had thrombocytopenia at the outset. Improvement after treatment was seen in all 4. The only serious side-effect that necessitated withdrawal of treatment was jaundice.

ISSN:0001-5792    

DOI:10.1159/000208422

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The increase of iron-binding capacity during pregnancy is not influenced by the increased production of oestriol from the fetoplacental unit.

ISSN:0001-5792    

DOI:10.1159/000208423

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Blood cultures in cases of chronic lymphocytic leukaemia showed a low number of macrophages in absence of phytohaemagglutinin (PHA), in addition to a low PHA blastic transformation of lymphocytes. Blood cultures from treated cases developed macrophages in quantities correlated to the grade of PHA blastic transformation and of therapeutic response. A relationship is suggested between the PHA blastic transformation of lymphocytes and the number of macrophages developing in vitro without PHA.

ISSN:0001-5792    

DOI:10.1159/000208424

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Two families are described in whom there is an inherited defect of platelet aggregation in response to ADP. This consists of a normal response to low concentrations but a reduced response to concentrations adequate to produce complete, irreversible aggregation in normal subjects. Ten times the usual concentration is required to produce such maximal aggregation. Aggregation in response to collagen is normal as is release of ADP in response to collagen. This anomalous behaviour is not due to a plasma ADPase. This defective behaviour can be duplicated by suitable manipulation of normal platelets and may not occur in vivo. The existence of this anomalous behaviour contradicts the hypothesis that collagen-induced aggregation is mediated by ADP released from platelets. This disorder has been named ‘Pearson-Stoba anomaly

ISSN:0001-5792    

DOI:10.1159/000208425

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The prolonged bleeding time in a 70- year-old man with a bleeding diathesis was attributed s to impaired platelet aggregation. This could be accounted for by the decrease of the platelet adhesiveness to collagen and the decreased release of adenosine diphosphate (ADP). The impaired availability of platelet factor 3 and acid phosphatase after induction by collagen was partly corrected by ADP or bovine fibrinogen. The total activity of platelet factor 3 and acid phosphatase was, however, normal in contrast to the lowered total activity of ADP and platelet factor 4, which showed even a disturbance of their release from platelets without any correction in the presence of ADP. Similarly, the total activity of β-glucuronidase was normal, though its release following collagen induction was impaired

ISSN:0001-5792    

DOI:10.1159/000208426

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208427

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208428

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208429

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208430

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208421

出版商:S. Karger AG    

年代:1973

数据来源: Karger