摘要:

Using light and electron microscopy, we studied four keratectomy specimens obtained by penetrating keratoplasty from four patients (ages 33-54 years; mean age: 43 years old) who had clinical evidence of Descemet's folds and bullous keratopathy after ruptures in Descemet's membrane after forceps injury at birth. Histopathologically, three patients showed the typical features of forceps birth injury: Descemet's membrane at the margin of the rupture was folded and assumed a scroll-shape configuration. The fourth patient showed clusters of proliferated endothelial cells at the site of two ruptures, and from one site of the ruptures, these cells invaded into Descemet's membrane, forming a new basement membrane. Transmission electron microscopy revealed that these proliferated cells were epithelial-like cells characterized by desmosomal junctions, basal lamina, numerous microvilli, and 8-nm cytoplasmic filaments. The epithelial transformation of the corneal endothelium was identified in cases of posterior polymorphous dystrophy and assumed to be specific for this entity. The findings in our fourth patient represent the first documentation of epithelial- like cells on the posterior corneal surface in forceps birth-injury-associated keratopathy. Our results suggest that epithelial transformation may be a nonspecific reaction of the young cornea to various stimuli.

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

We describe a case of calcific band keratopathy in a patient with a nut-and-bolt keratoprosthesis. To our knowledge, this is the first reported case of this condition involving a prosthesis. The patient had initially suffered lye burns to both eyes. The prosthesis was placed in the right eye; numerous procedures had to be undertaken to maintain it. The patient was also treated surgically and pharmacologically for glaucoma. Seventeen years after initial implantation, white flakes appeared on the prosthesis in the classical band pattern. Pathologic examination revealed them to be calcific. Theories concerning corneal and contact lens calcific deposition are evaluated to assess their applicability to this case. We conclude that multiple factors may be responsible for calcific deposition on the keratoprosthesis and that this may call into question previous explanations of this disorder.

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

The Kayser-Fleischer ring of the cornea is usually considered a pathognomonic finding of Wilson's disease. case of a Kayser-Fleischer ring associated with non- Wilsonian liver disease is presented. The pathophysiology of copper deposition in the cornea and the differential diagnosis of this rare finding are discussed.

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

We report two unusual causes of giant papillary conjunctivitis (GPC). One patient developed GPC secondary to an elevated filtering bleb. Another patient developed focal GPC secondary to elevated calcific plaques (band keratopathy). The first patient's symptoms improved after treatment with sodium cromolyn drops. GPC resolved in the second patient after superficial keratectomy was performed. These cases represent two unusual causes of GPC and emphasize the role of mechanical trauma as causative factor.

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

Pythium insidiosumis a fungus-like organism known to infect a variety of animals. In humans, the few known cases involving Pythium have included arterial infections and cellulitis. We present what we believe to be the first case ofP. insidiosum recovered from a human corneal ulcer. The organism is difficult to isolate, causing delays in diagnosis. It is also resistant to the usual antifungal medications, making surgical excision the treatment choice.

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1993

数据来源: OVID