摘要:

Xeroderma pigmentosum is an uncommon inherited disorder characterized by hypersensitivity to ultraviolet radiation, with defective repair of DNA damage caused by short-wavelength radiation. Corneal complications of this disorder may require penetrating keratoplasty for visual rehabilitation. Surgery is rarely undertaken in these eyes due to multiple associated problems involving the ocular surface and the lids. We report three cases of successful penetrating keratoplasty in xeroderma pigmentosum and review nine cases reported earlier. Successful grafts were achieved in all 12 eyes initially. Persistent superficial punctate keratopathy was observed in one eye and graft rejection episodes in five eyes. However, graft failure occurred due to an untreated rejection episode in only one eye. Another eye was treated by exenteration for recurrent ocular malignancies. This report highlights the encouraging results of penetrating keratoplasty in carefully selected patients of xeroderma pigmentosum with corneal pathology.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

We describe a patient with congenital syphilis associated with corneal neovascularization and subsequent intra-corneal hemorrhage. Over time, this condition resulted in acquired posterior keratoconus. A review of our clinical case, the literature, and histologic findings is presented. To our knowledge, this is the first reported case of acquired posterior keratoconus associated with corneal vas-cularization and hemorrhage secondary to congenital syphilis. We also have provided histopathologic evidence for the prescence of an iron ring.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

A patient with a steroid-resistant conjunctival nodule developed severe necrotizing granulomatous conjunctivitis during aggressive treatment with topical, subconjunctival, and systemic steroids. Culture of the tissue yielded Coccidioides immitis. A cavitary lesion was noted on a chest radiograph, and the same organism was recovered from a lung biopsy specimen. The granulomatous conjunctivitis was controlled only after aggressive debridement of the affected area and months of treatment with topical amphotericin B and oral fluconazole. A review of the literature suggests that subclinical ocular involvement from pulmonary coccidioidomycosis may be more common than generally believed. Conditions that blunt the host immune response may lead to a higher incidence of clinically significant ocular involvement.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID