摘要:

Adult male mice from four inbred albino strains (SJL/J, NZW/BL, BALB/c HeA, and SWR/J) were subjected to ultraviolet radiation (UVR) exposure (302 nm peak wavelength, intensity 398 µW/cm2for 3.25 min and photographed 4 days postexposure to assess corneal clouding. Corneal extracts from control (unexposed) mice from each strain, were also monitored for aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) activity and soluble protein content. The SWR/J strain exhibited more extensive corneal clouding after UV exposure than did the other strains, and control SWR/J mice exhibited a low activity variant phenotype for the major ocular ALDH AHD-4, and decreased levels of soluble protein in corneal extracts. These data support earlier proposals for a major role for ALDH in assisting the cornea in protecting the eye against UVR-induced tissue damage.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

90% of the cases. Recurrence of keratoconus following penetrating keratoplasty has been previously reported, based on a clinical diagnosis, and confirmed by histopathological examination. We report the clinicopathologic features of two further cases of recurrent keratoconus.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

We report herein a patient with iridoschisis and keratoconus. Since the posterior layers of the cornea and the iris stroma have a common embryological deviation, the combination of these two conditions suggests an interrelated pathogenesis. This case is similar to those of patients with progressive essential iris atrophy and keratoconus described by Cavanagh.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Crouzon's syndrome is an autosomal dominant disorder characterized by premature craniosynostosis leading multiple ocular abnormalities and vision loss. Strabismus, optic atrophy, exposure keratitis, hypertelorism, nystagmus, and unexplained visual loss have been reported. Keratoconus has been described only once previously patient with other ocular abnormalities. This article reports bilateral keratoconus in a patient with Crouzon's syndrome without other ocular pathology. We emphasize the importance of early recognition and therapy of this treatable cause of decreased vision in Crouzon's syndrome.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Three patients with corneal or scleral defects were treated with Gore-Tex grafting, including one case of corneal ulcer, one case of Mooren's ulcer, and one case of necrotizing scleritis. These eyes remained inflamed after Gore-Tex grafting. The interval between grafting and removal ranged from 2 months to 1 year. Pathologically, none of these grafts showed evident epithelial or fibrous tissue ingrowth of the Gore-Tex graft. Fungal inhabitation was noted in one graft, and fungal endophthalmitis developed 5 months after graft removal and penetrating keratoplasty. Although Gore-Tex offers some advantages, it has disadvantages when it is used without adequate conjunctival covering, including poor epithelialization, poor adhesion between graft and surrounding tissue, and potential infectious route.

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1994

数据来源: OVID