ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

The healing and remodeling of a stromal incision is described at the gross, fibrillar, and cellular levels. The possibility that the healing of the wound and the clearing of the scar can be accelerated by biological interventions is discussed. Castroviejo Lecture was given on November 9, 1986.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

This article reports a case of bilateral corneal pellucid marginal degeneration. The right cornea had an acute hydrops. Both eyes underwent penetrating keratoplasty. A histopathological study of the corneal specimens was performed by light and electron microscopy. The histological changes observed on the right cornea showed breaks on Bowman's layer, edema and disorganization of the stromal collagen, and break of Descemet's membrane. The ultrastructural changes were similar to those observed in acute keratoconus, leading to the belief that these two corneal diseases are closely related.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

A healthy 28-year-old man developed a slowly progressive corneal ulcer 21 months after an episode of corneal trauma. Acid-fast bacilli were identified in corneal scrapings, and the causative organism was identified asMycobacterium avium-intracellulare.Medical treatment with topical amikacin and oral rifampin was ineffective, and a therapeutic penetrating keratoplasty was necessary to cure the infection. To the best of our knowledge, this is only the second reported case of a corneal infection caused by a slow-growing nontuberculous mycobacterium (Runyon groups I, II, and III) and the first caused byM. avium-intracellulare.Slowly growing nontuberculous mycobacteria should be considered among those organisms that cause corneal infection, especially in cases characterized by a protracted course and lack of response to conventional antimicrobial therapy.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Penetrating keratoplasty frequently results in postoperative astigmatism. A rabbit model was used to investigate the relationship between the ovality of the recipient bed and the resulting postoperative astigmatism as measured by keratometry. Animals were grouped based on the extent that the recipient bed deviated from a 7.25-mm diameter circle (ovality of bed). All animals received a round 7.75-mm donor corneal button. With increasing ovality of the recipient bed, there was a corresponding increase in the postoperative astigmatism at 3 months after all sutures were removed.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Successful corneal transplantation was accomplished following metabolic phosphorus magnetic resonance analysis. Four cat corneas were analyzed using phosphorus-31 magnetic resonance following storage in modified McCarey-Kaufman (M-K) medium for 24 h. Corneas were re-stored in M-K medium and transplanted 24 h after MR analysis. Four control corneas (contralateral eye, no magnetic resonance analysis performed) were also transplanted following storage in M-K medium under identical conditions. Successful corneal transplantation was accomplished with minimal ATP tissue levels. Corneas stored for 48 h maintained a pH of 7.3. The phosphorus-31 spectral modulus, which is the ratio of the high-energy phosphates to the low-energy phosphates, was calculated using the spectral integral (range, 0.49–0.77). No difference in endothelial cell density or morphology was detected between corneas following magnetic resonance analysis and control corneas when evaluated by specular microscopy.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Actin is associated with motility, cell morphology, and cell-substrate adhesion. The molecular probe NBD phallacidin, which reacts with filamentous actin, was used to study the distribution of actin filaments in the corneal and conjunctival epithelium, stroma, and endothelium. Frozen sections of human fetal eyes from 8 weeks to 40 weeks of gestation were reacted with NBD phallacidin. Pathologic tissues included keratoplasty specimens from patients with hereditary posterior polymorphous corneal dystrophy (PPMD) and surgically excised tissues removed for treatment of epithelial down-growth. Normal human cornea was used as a control. Immunofluorescent staining disclosed actin filament distribution in corneal epithelium as early as 9–10 weeks of gestation. Staining increased with maturation until term. Adult human corneal epithelium showed more pronounced staining of the surface layers. Stromal staining was more extensive in earlier stages of gestation and decreased in later stages of gestation, after 20–21 weeks. In pathologic corneas with posterior polymorphous dystrophy, there was localization of actin, as well as keratin in the abnormal epithelial-like layers lining the posterior cornea. In epithelial downgrowth, actin and keratin were demonstrated in multilayered squamous epithelium on the anterior iris surface. Actin appears to be involved in migration of corneal epithelial and endothelial cells.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

In order for a refractive surgical procedure to be generally accepted, it must give a predictable result as well as generate a suitable optical surface. Previously, in a non-human primate model, we showed that hydrogel intracorneal lenses could flatten the cornea and thereby be used as a potential treatment for myopia. Over 20 D of central corneal flattening was observed in some cases. It was evident that the major corneal flattening occurred only in a very small area covered by the first corneascopic ring and that this area was irregular in that an elliptical reflection was generally obtained. We herein present the results of myopic hydrogel lens design modification. By enlarging the size of the lens and optical zone, the central corneal flattening became more regular as judged by corneascopic analysis. With the most recent lens designs, animals with high-minus implants showed circular corneascopic images with an average of 10.0 D of central flattening. This observation of corneal flattening was confirmed with autorefractor readings (average, −8.5 D) and keratometric readings (average, −9.0 D). These results are compared with earlier lens implants 5.5 mm in diameter where flattening was documented by reading the central corneascopic ring and could not be confirmed with either keratometric or autorefractor data. We feel these preliminary attempts at lens design modification have significantly enhanced the potential for future clinical application of this technique.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Forty-nine cases of primary keratophakia and 13 cases of secondary keratophakia were analyzed for postoperative astigmatism. For primary cases, the surgically induced astigmatism was 1.55 D, whereas for secondary cases it was 0.19 D (insignificant). There was a tendency for both procedures to induce against-the-rule astigmatism, and both procedures were found capable of producing irregular astigmatism.

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0277-3740    

出版商:OVID    

年代:1987

数据来源: OVID