摘要:

Diffuse pulmonary fibroleiomyomas were detected by open-lung biopsy in a 33-year-old male patient. Lung function studies revealed severe airflow obstruction, hyperinflation, grossly impaired single-breath-diffusing capacity and a decrease in PaO2 during exercise, i.e. data which are compatible with pulmonary emphysema. However, static lung compliance was within normal limits excluding the existence of pure emphysema. Additional special lung function tests confirmed the assumption that in diffuse fibroleiomyomas of the lung, functional patterns characteristic of obstructive and restrictive lung disease are present that are in agreement with the histological features of this disease

ISSN:0025-7931    

DOI:10.1159/000194286

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Ventilation (VA) perfusion (0) ratios distribution measured by the inert gases method is studied in 7 anesthetized dogs in supine position, in prone position at arespiratory frequency of 15 cpm, and in prone position at a respiratory frequency of 10 cpm so as to test the sensitivity of this VA/Q method. Despite the fact that the precise height-width characteristics of the distribution modes are unknown, our results show coherent changes and sensitivity of the log standard deviation of the perfusion curve, of the shunt, and of the dead space obtained with the inert gas method. After the change from supine to prone position, cardiac output increases, shunt, if it exists, diminishes, VA/Δ ratios distribution becomes more uniform, and PaO2 increases and (A-a)DO2 decreases. When respiratory frequency changes from 15 to 10 cpm, cardiac output, shunt, and dead space decrease, VA/Q ratios distribution curves are slightly less homogeneous. PaO2 and PaCO2 show no significant variation. This study shows the distribution mode’s characteristics can be considered as good and coherent approximatio

ISSN:0025-7931    

DOI:10.1159/000194287

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Ventilatory response to CO2 (ΔVE/ΔPco2), respiratory drive (z(P0.1t/ΔPco2), breath-holding time (BHT) on 100% O2 and log BHT/Pco2 slope during CO2 rebreathing was assessed, in 19 control subjects and in 22 patients with chronic obstructive pulmonary disease (COPD) with hypercapnia (Pco2 50 mmHg). The log BHT/Pco2 slope was expressed as the PCO2 increment to half the BHT. We found no correlation between BHT on 100% O2 and ΔVE/ΔPco2 or ΔP0.1/ΔPco2 in controls and COPD subjects. ΔPco2 halving BHT had an inverse statistical significant correlation with ΔVE/ΔPco2 and ΔP0.1/ΔPco2 in controls and patients. In contrast to ΔP0.1/ΔPco2, the ΔPco2 halving BHT increased in COPD patients and there are patients with normal respiratory drive but prolonged ΔPco2 halving BHT. The ΔPco2 halving BHT as ΔVE/ΔPco2 cannot be substituted for ΔP0.1/ΔPco2in the clinical assessment of respiratory chemosensitiv

ISSN:0025-7931    

DOI:10.1159/000194288

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The method of rheospirography was investigated in 26 voluntary test persons. By means of a spirometric measuring method and after calibration, quantitative statements about size and changes of respiratory minute volume and inspiratory volume could also be evaluated. Computerizing the computation method, rheospirography is suitable for long-term monitoring in intensive care patients.

ISSN:0025-7931    

DOI:10.1159/000194289

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Hemodynamic and ventilatory effects of i.v. administration of salbutamol (3 μg/kg body weight) have been studied in 6 patients affected by chronic obstructive lung disease. A fall of mean pulmonary arterial pressure (PAP), pulmonary vascular resistances index (PVRI), left ventricular end-diastolic pressure (LVEDP) and systemic vascular resistances index (SVRI) have been found significant. Furthermore, heart rate (HR), cardiac index (CI) and left ventricle dp/dt max (LV dp/dt max) were early and remarkably increased. At 30 min after drug administration such effects disappeared in all patients. Regarding the ventilatory data, the authors assume that a significant and precocious FEV1 and vital capacity increase was still present at 30 min. Hemodynamic effects can be related to either an increased venous return due to peripheral vasodilatation or to a β1-cardiac receptor stimulatio

ISSN:0025-7931    

DOI:10.1159/000194294

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

In a cross-over experiment, 16 adult asthmatics slowly inhaled, at functional residual capacity, cumulative doses of terbutaline spray with and without extension of the mouthpiece of the aerosol canister by a cylindrical tube (length 10.0 cm, diameter 3.2 cm). No difference was found between the two modes of treatment with regard to the bronchodilator response assessed by measurement of specific airway conductance, registration of expiratory flow-volume curves and determination of helium response. The results suggest that the use of an extension tube may not promote a more extensive nor a more peripheral deposition in the bronchial tree of a properly inhaled pressurized aerosol drug.

ISSN:0025-7931    

DOI:10.1159/000194290

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Severe hypokalemia (2.6 mEq/1), hypomagnesemia (0.6 mg/dl), mild hypercalcemia (10.9 mg/dl), and secondary hyperaldosteronism developed in a patient receiving viomycin for pulmonary tuberculosis. Reversible renal wasting of both potassium (K+) and magnesium (Mg++) was documented. Viomycin administered to 40 rats resulted in severe damage to the proximal tubule and mild damage to the distal tubule. The case report and experimental data suggest viomycin induces proximal tubule dysfunction that results in renal wasting of sodium, K+ and Mg++ and secondary hyperaldosteronism. Hypercalcemia, not previously associated with viomycin therapy, may be secondary to hypomagnesemia-induced hyperparathyroidism

ISSN:0025-7931    

DOI:10.1159/000194291

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0025-7931    

DOI:10.1159/000194292

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0025-7931    

DOI:10.1159/000194293

出版商:S. Karger AG    

年代:1980

数据来源: Karger