摘要:

Comparisons with 14 normal, younger, male native residents of La Paz showed that 20 patients with Monge’s syndrome have significantly higher mean body surface areas, hemoglobin, resting tidal volumes [VT (BTPS)], and resting minute volumes [VE (BTPS)]. If [VE (BTPS) is subdivided into its components of alveolar [Va (BTPS)] and dead space ventilations [VDS (BTPS)], it becomes apparent that the former is significantly smaller and the latter much larger in the Monge patients than in the controls. Alveolar hypoventilation in the Monge group is evidenced by an elevated mean PaCO2; a lower mean pH of 7.349, contrasted with that of 7.399 in the controls; a PaO2 of 48.1 mm Hg, compared with 57.7 mm Hg in the normals. Simultaneous surface scanning of the right upper and lower lung zones, using a central venous injection of 131I-HSA (human iodinated serum albumin), showed a reduction of total isotope activity in the right upper zones of the Monge grou

ISSN:0025-7931    

DOI:10.1159/000192835

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

In 23 patients with anemia or polycythemia but normal lung function, a statistically significant correlation between hemoglobin concentration in the blood -and the diffusing capacity of the lung for CO was found. A change of 1 g hemoglobin per 100 ml blood changes blood the diffusing capacity for about 6.5 % of the predicted value. The diffusing capacity of the lung membrane will be less than 50 % of the total lung capacity with decreasing hemoglobin concentration in the blood. This result confirms the theory of Koyama and Mochizuki [1969] that the resistance to diffusion of the lung membrane is a function of the hemoglobin concentration of the lung capillary blood.

ISSN:0025-7931    

DOI:10.1159/000192836

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The relationships between various inspired oxygen concentrations and the oxygen saturation of endcapillary pulmonary blooddependentonventilation perfusion and diffusing capacity – perfusion abnormalities can be estimated by means of a diagram. It lends itself to general considerations about the rational use of oxygen in patients with chronic pulmonary disease. It is shown that these considerations are highly applicable to several groups of patients in which these abnormalities have been investigated and that inspired oxygen concentration may be limited to various degrees relevant to the nature of the functional disturbances.Relationships Between Oxygen Saturation of Endcapillary Pulmonary Blood and Inspired Oxygen Concentrations in the Inhomogeneous Lung Considerations About the Rational Application of Oxygen in Chronic Pulmonary Disease Untersuchungen der letzten Jahre haben ergeben, dass die kontinuier-liche Sauerstoffanwendung zur Behandlung von Patienten mit chronisch-obstruktiven Lungenerkrankungen und respiratorischer Insuffizienz gerecht-fertigt ist. Durch die bessere Oxygenierung des Blutes werden nicht nur der Atemwegswiderstand signifikant gesenkt und die Polyglobulie zum Ver-schwinden gebracht, sondern vor allem wird auch die pulmonale Hyper-tonie entscheidend gesenkt [14,18]. Zahlreiche klinische Beobachtungen haben aber gezeigt, dass der Erfolg der Sauerstofftherapie bezüglich der V

ISSN:0025-7931    

DOI:10.1159/000192837

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Gaseous exchange and pulmonary hemodynamic data were studied in 34 patients with chronic obstructive lung disease, during acute respiratory failure. Control tests were carried out in 20 patients after recovery. Pulmonary hemodynamic studies were performed by the microcatheterization method (floating catheter). On an average cardiac output was found normal during acute failure and it did not change significantly after recovery. During acute respiratory failure the mean PAP increased from 25.6 to 39.4 mm Hg (P < 0.001). Hypoxia accounts the best for this increase of the PAP : PAP is well correlated with the decrease of arterial PO2 during acute failure (r = 0.75; P < 0.001). The influence of hypercapnia and acidosis on pulmonary hemodynamics seems to be very small in our patients; likewise the influence of mechanical factors (elevated alveolar pressure) seems to be negligible. Contrary to some authors we have not found elevated pulmonary capillary pressures during acute respiratory failure.

ISSN:0025-7931    

DOI:10.1159/000192838

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The incidence of complications after pulmonary resection was studied in 122 patients with different pulmonary diseases and varying degrees of ventilatory insufficiency. These patients had preoperative tests to determine if there was a contraindication to the type of surgery planned. From the results of the pulmonary function tests a resection of more than a lobe was considered contraindicated if the vital capacity in the first second was less than one liter and if the ventilation was evenly distributed between the two lungs. Because of this, surgery could not be carried out in nine patients. The pulmonary resection was uneventful in 97 patients, 25 patients (22 % of the total number) had complications and 5 of them died (4 % mortality rate). The pulmonary function studies showed a marked ventilatory insufficiency and a functionless left lung, in the patient who died from respiratory insufficiency after a left pneumonectomy. In the other patients mechanical and infectious factors were involved in the production of complications. Pulmonary function studies were needed to establish the contraindications for surgery. Regional lung function studies were valuable to map the extent of resection.

ISSN:0025-7931    

DOI:10.1159/000192839

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0025-7931    

DOI:10.1159/000192840

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0025-7931    

DOI:10.1159/000192841

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0025-7931    

DOI:10.1159/000192834

出版商:S. Karger AG    

年代:1971

数据来源: Karger