摘要:

Specific interactions of some simple transition metal complexes with DNA are described. Several binding modes and reactions, intercalation, covalent modification, and oxidative cleavage, are discussed and all have in common the specific recognition by metal complexes of subtle features of DNA helical structure. The versatility of the metal center, from its spectroscopic properties to stereochemistry, suggests that coordination complexes may be promising candidates to exploit in the design of drugs and probes for DNA.

ISSN:0260-3594    

DOI:10.1080/02603598508079690

出版商:Taylor & Francis Group    

年代:1985

数据来源: Taylor

摘要:

Models that have been proposed for the substitution reactions of transition metal excited states generally involve high energy electronic configurations of intermediate species and such pathways may not be viable for vibrationally equilibrated excited states. Nevertheless, simple angular overlap considerations indicate that several dissociative and associative intermediate species are likely to have energies comparable to, or less than these vibrationally equilibrated ligand field excited states. A model is proposed for estimating the intrinsic nuclear barriers to formation of trigonal bipyramidal Cr(III) intermediates and there does seem to be some basis for stereoselectivity. Among possible seven-coordinate intermediates, the capped trigonal prismatic geometry seems most likely to be consistent with observed chromium photosubstitution chemistry.

ISSN:0260-3594    

DOI:10.1080/02603598508079691

出版商:Taylor & Francis Group    

年代:1985

数据来源: Taylor

摘要:

Various techniques used for the measurement of intramolecular electron-transfer rales in inorganic systems are considered, and recent applications are described. The methods include electron paramagnetic resonance, Mossbauer spectroscopy, nuclear magnetic resonance, vibrational spectroscopy, dielectric relaxation, pulse radiolysis, photochemistry, electrochemistry, and chemical approaches.

ISSN:0260-3594    

DOI:10.1080/02603598508079692

出版商:Taylor & Francis Group    

年代:1985

数据来源: Taylor

摘要:

This is a scanned image of the original Editorial Board page(s) for this issue.

ISSN:0260-3594    

DOI:10.1080/02603598508079689

出版商:Taylor & Francis Group    

年代:1985

数据来源: Taylor