摘要:

SummaryMurine toxoplasmosis caused by a low virulence, cyst‐forming strain ofToxcoplasma gondii(Pe strain) is characterized by splenomegaly, lymphadenopathy, decreased delayed‐type hypersensitivity (DTH), and the presence of toxoplasma cysts in brain tissue. Cyclophosphamide (CY) in a single dose of 100 mg/kg injected 3 days before infection, or splenectomy 3 weeks before infection, augmented DTH and decreased the number of toxoplasma brain cysts. CY‐induced augmentation of resistance during the first 3 weeks of murine toxoplasmosis was associated with: (1) an increase in mononuclear phagocytes and a decrease in T lymphocytes (including Lyt2+cells) in spleens and lymph nodes; (2) suppressed toxoplasma antigen induced proliferation of cultured spleen cells: (3) augmentation of antigen induced proliferation of cultured lymph node cells; and (4) low levels of interferon‐γ production in both spleen and lymph node cultures. The best correlate of the enhanced in‐vivo effects of CY was proliferation of nylon wool‐purified lymph node cells to toxoplasma antigen. The presence of Lyt2+cells in lymph nodes of toxoplasma infected mice inhibited maximal p

ISSN:0141-9838    

DOI:10.1111/j.1365-3024.1987.tb00493.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryThe participation ofToxocara canislarval excretory‐secretory antigens in immune‐mediated adherence was determinedin vitro.Adsorption of immune sera with excretory‐secretory antigens removed some complement components, removed IgG antibody directed against larval surfaces, and abrogated all adherence observed with untreated immune serum. At least four antigens could be implicated in adherence, by Western blot analysis of adherence mediating sera.Scanning and transmission electron microscopic examination of larvaleosinophil interactions revealed that eosinophils adhered to a membranous sheath‐like layer that was frequently detached from the larval epicuticle. The layers appeared to be composed of surface antigens and antibody, and may provide larvae with protection against antibody and eosinophil toxins by preventing their contact with the epicuticle. The release of surface antigens also may be important in allowing larvae to evade the host's immune response by facilitating the removal of antibody and eosinophils from the larval

ISSN:0141-9838    

DOI:10.1111/j.1365-3024.1987.tb00494.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0141-9838    

DOI:10.1111/j.1365-3024.1987.tb00495.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY