摘要:

AbstractThe paper presents results and experience obtained in the isolation of a number of basic polar/non‐polar solutes (drugs, their metabolites and structural derivatives) from biological samples by using the separation minicolumns SeparcolRSI and SeparcolRSI C18 L/T. The aim was to provide insight into some simple procedures yielding optimal selectivity/specificity of the isolation of the studied solutes either by proper selection of the sorbent or by applying sophisticated elution schemes which use to advantage different properties of the eluents/solvent

ISSN:0269-3879    

DOI:10.1002/bmc.1130060112

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

摘要:

AbstractOrosomucoid, a member of the lipocalin family, may function in thein vivotransport of lipophilic compounds such as basic and neutral drugs. We describe the identification of 7‐chloro‐1‐methyl‐1,5‐benzodiazepine‐2,4‐dione (clobazam) bound to the serum orosomucoid from individuals actively taking this tranquillizer. This suggests not only that other endogenous factors limit access to the benzodiazepine binding site on human serum albumin, but also that the differential binding of benzodiazepines and their metabolites by orosomucoid should be considered in determining therapeutic doses, particularly in the acute p

ISSN:0269-3879    

DOI:10.1002/bmc.1130060113

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

ISSN:0269-3879    

DOI:10.1002/bmc.1130060114

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY

ISSN:0269-3879    

DOI:10.1002/bmc.1130060101

出版商:John Wiley&Sons, Ltd.    

年代:1992

数据来源: WILEY