摘要:

The clinical and histological appearances of four cases of idiopathic atrophy of the nails are described. The findings do not support previous contentions that lichen planus is the underlying pathological process.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

We report the development of a lymphoproliferative reaction in the red areas of a tattoo in a 53-year-old man. The results of histologic and immunohistochemical studies were consistent with a diagnosis of lymphadenosis benigna cutis. Patch tests showed a strong, delayed-type hypersensitivity to several mercury products. The pathogenetic mechanisms operative in the development of this reaction are discussed.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A 39-year-old woman who had cryptogenic cirrhosis and who had received two liver transplants developed necrotic skin lesions over the chest, upper arms, and thighs. Biopsy showed enlarged endothelial cells with intranuclear and intracytoplasmic inclusions characteristic of cytomegalovirus (CMV) infection. However, a few multinucleated gaint cells were observed beneath a necrotic epidermis. This, combined with the clinical presentation, suggested to infectious disease consultants an infection with herpes simplex virus. Using the immunoperoxidase technique, inclusions stained positively with antibody to CMV and showed a negative reaction for herpes simplex antigen. In situ hybridization using biotinylated DNA probes on formalin-fixed, paraffin-embedded tissue sections confirmed the diagnosis of CMV infection and failed to substantiate infection with herpes simplex virus. Subsequently, blood cultures became positive for CMV. The early recognition of CMV infection in the skin permitted institution of antiviral therapy with gancyclovir. Specific skin lesions of CMV infection are likely to be encountered with increasing frequency among immunosuppressed patients. Lesions may be vesicular, and epidermal multinucleated giant cells can occasionally be identified. In situ hybridization is a technique that is readily adaptable to surgical pathology laboratories and permits both a rapid, specific diagnosis and the early institution of appropriate therapy.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

The metaplastic synovial cyst (synovial metaplasia of the skin) is a recently described intradermal cyst lined by a membrane that resembles hyperplastic synovium. All of the reported cases thus far have occurred in adults after surgical incision. A case of metaplastic synovial cyst after partial excision of nevus sebaceus in a 7-year-old girl is herein reported. Pathogenesis and light-microscopic and immunohistochemical features of this case are discussed.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A unique case of a cutaneous malignant melanoma arising in a black man with a familial history of neurofibromatosis (von Recklinghausen's disease) is reported. Although neurofibromatosis is believed to be a disorder of neural crest origin that is associated with a number of different malignancies; a definite association of malignant melanoma with neurofibromatosis has not been reported. The presence of a malignant melanoma arising on the trunk of a black man suggests an association of cutaneous malignant melanoma and neurofibromatosis—a malignancy and genodermatosis, respectively—of ultimate neural crest origin.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A case of an adenomatous sweat gland hamartoma present since birth is described. The histological and ultrastructural findings were similar to those of spiradenoma, and carcinoembryonic antigen, usually present in cutaneous sweat gland tumors, was also demonstrated. Sweat gland nevi are rare, and a spiradenomatous variant has not been previously documented.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID