ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Fifty-five patients with extramammary Paget's disease were the source of material for this study. Step-sections were done through most of the specimens. Clinical information, including follow-up, was obtained on 45 of the 55 patients.Extramammary Paget's disease could be divided histologically according to where Paget cells were found, namely: 1) wholly within the epidermis and the epithelial structures of adnexa; 2) within the epidermis, the epithelial structures of adnexa, and the dermis; 3) within the epidermis, the epithelial structures of adnexa, and contiguous epithelia of other organs such as the genitourinary and gastrointestinal tracts.Our conclusions are that extramammary Paget's disease is more than one disease and in most instances begins in the epidermis as an adenocarcinoma and extends from there into contiguous epithelium of hair follicles and eccrine sweat ducts. Uncommonly, Paget cells extend from the epidermis into the dermis and from there may metastasize. Rarely, extramammary Paget's disease results from direct extension into the skin of an adenocarcinoma in a contiguous organ such as the genitourinary or gastrointestinal tract.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

Apoptosis is a distinctive mode of cell death with characteristic morphologic features which serves as a balance to mitosis in regulating the size of animal tissues. In contrast to coagulative necrosis, the cytologic features of apoptosis suggest active self-destruction rather than progressive disintegration. It typically affects scattered individual cells which condense and bud to produce many membrane-bounded fragments in which organelles appear intact when viewed by the electron microscope. These apoptotic bodies are then phagocytosed and digested by cells resident in the tissue. Apoptosis, unlike coagulative necrosis, does not itself evoke an inflammatory response. Apoptosis is a feature of such diverse processes as deletion of phylogenetic vestiges during normal embryonic development, involution of endocrine-dependent organs after withdrawal of trophic hormones, cell-mediated immune attack on tissues, and therapeutically induced regression of neoplasms.Apoptosis has received scant attention in dermatopathology. However, it is now known to be an important feature of lichen planus, certain drug eruptions, the skin lesions of graft-versus-host reactions, the regression of plane warts, and the effects of ultraviolet damage. It is also involved in the kinetics of cutaneous neoplasms. In some of these situations, apoptotic bodies have, in the past, been given names such as Civatte bodies, colloid bodies, single-cell necrobiosis, sunburn cells, and dyskeratotic cells without their basic nature having been recognized.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID