摘要:

This study of mammary Paget's disease was carried out with the objects of clarifying its histogenesis and of determining optimal diagnostic measures. Ten consecutive cases of mammary Paget's disease with their underlying ductal carcinomas were compared. Histologic, histochemical, and immunocytochemical examination mainly supported the hypothesis that mammary Paget's disease is an extension of mammary ductal carcinoma into the overlying nipple epithelium. However, two of our ductal carcinomas stained strongly with S-100 protein, while Paget's disease was uniformly negative with this antibody. The significance of this finding is not known. Optimal diagnostic accuracy is obtained by using a combination of routinely stained sections along with a panel of immunocytochemical stains. Nipple wedge biopsy may demonstrate both intraduct carcinoma and Paget's disease, and is thus a superior biopsy technique.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

The term parapsoriasis refers to a group of chronic asymptomatic scaly dermatoses of unknown etiology about which there is still controversy over the nosology and nomenclature of the different conditions that comprise the group, particularly pityriasis lichenoides chronica (PLC) and small plaque parapsoriasis (SPP). In an attempt to establish the distinctive clinicopathologic features of these two dermatosis, we prospectively studied 44 patients who presented with the typical clinical and histologic picture of either of these two diseases. SPP was clinically characterized by scaly oval plaques on the trunk and proximal aspect of extremities. Spongiosis was the salient histopathologic feature, with absence of fibrosis or melanophages. PLC presented with a scaly papular eruption over the trunk and extremities and histologically was characterized by an interface dermatitis. We conclude that sufficient clinical and histologic features differentiate these two entities and we propose that the term parapsoriasis be used only to designate SPP and large plaque parapsoriasis.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Although it was first described by Pinkus in 1970, the entity known as large cell acanthoma (LCA) has been largely ignored. In this paper, we review the clinical and histopathologic features of 11 solitary and three multiple cases of LCA. We also compare this series with two previous reports, one by Rahbari and Pinkus and one by Rabinowitz. From the analysis of these 70 cases, we conclude that although LCA is not uncommon (it occurs in 1–2.55 per 1,000 cutaneous biopsies), as an asymptomatic, slightly keratotic lesion, usually less than 10 mm in size, it has been largely underestimated. It is more common in women than in men and mainly affects middle-aged and elderly patients. LCA is found mainly on the face and upper limbs yet in the multiple cases, the lesions seem to occur on the limbs and the back. Histologically, it can be distinguished by the large size of the malpighian cells, both nucleus and cytoplasm. The lesion is sharply limited from normal epidermis and usually shows acanthosis, hypergranulosis, and hyperorthokeratosis. Finally, we discuss the nature of LCA. Based on the frequent disordered arrangement of the malpighian cells, its nuclear variability and the occasional finding of dyskeratoses and suprabasal mitoses, as well as the involvement of skin appendages, we conclude that LCA is probably a cytologic variant of Bowen's disease.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Three cutaneous tumors showing massively thickened nerve fascicles, with a myxomatous matrix in a diffuse tumor mass, were studied by light and electron microscopy, immunohistochemically, and with3H-thymidine autoradiography. Corresponding to plexiforme neurofibroma, these tumors were called plexiforme neurofibroma of the skin and are compared with nerve sheath myxoma (i.e., cutaneous lobular neuromyxoma, bizarre cutaneous neurofibroma, neurothekoma, and others). In the tumors, a high proportion of perineurial cells (30%) could be detected. Compared with results from regenerating nerves, organized traumatic neuroma, and other types of neurofibroma, these findings show that all constituents of normal peripheral nerves, especially Schwann cells and perineurial cells, may be involved in the growth of peripheral nerve sheath tumors. Furthermore, autoradiography demonstrated a high proliferative activity in one of the tumors. The possible clinical relevance of this finding and the question of whether these tumors may bear a higher risk for malignancy will be discussed.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

We report the clinical and histological changes of small pustules that developed in four patients with Kawasaki disease (KD). The small pustules were superimposed on the urticarial erythem and symmetrically arranged on the genital area, buttocks, axillae, and extensor surface of the extremities. These lesions showed spongiform pustules histologically and were different from miliarial pustules. Reviewing previous reports, the clinical and histological characteristics of pustules in KD are summarized herein. This study indicates that small pustules underwent the consecutive changes related to the generalized polymorphous exanthem in KD.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

We treated a 13-year-old girl who had annular erythematous lesions with central atrophic areas, which had been present on her trunk and limbs for 4 months. Histological examination revealed patchy dermal lymphohistiocytic infiltration with multinucleated giant cells which were phagocytosing elastic fibers, causing them to disappear. The active border of the lesions regressed after intradermal injection of corticosteroids. The classification of the disease and its differential diagnosis from the usual granuloma annulare, inflammatory anetoderma, O'Brien's actinic granuloma, and Convit's disease are discussed.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A 16-year old girl developed multiple, well-demarcated, extremely painful, hyperkeratotic nodules on her left sole. Histologic examination revealed a cornoid lamella and transepidermal elimination of blood vessels and collagen fibers which may be caused by the acceleration of keratinization. The pain and tenderness may have been partially related to epidermal disruption.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A case is presented of a multifocal malignant neoplasm involving the skin of the upper back in a 10-year-old boy following radiation therapy to the head and neck for a cerebellar medulloblastoma. Histologically, the neoplastic cells were remarkable for the presence of abundant periodic acid-Schiff (PAS)-positive diastase-resistant intracytoplasmic eosinophilic granules. Immunoperoxidase procedures revealed strong positive staining of the tumor cells with desmin, vimentin, and smooth muscle myosin antibodies, and negative staining for myoglobin, S-100 protein and keratin, thus supporting a smooth muscle line of differentiation for this neoplasm. Electron-microscopy demonstrated numerous intracytoplasmic autophagic vacuoles that corresponded to the granules observed under the light microscope. Leiomyosarcoma should be entertained in the differential diagnosis of poorly differentiated cutaneous neoplasms histologically characterized by a proliferation of cells containing abundant granular eosinophilic cytoplasm.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A case of metastatic adenocarcinoma in the skin of the thigh with an unconfirmed origin is described. Bullous pemphigoid antigen, which is present in the normal basement zone of stratified epithelia, was haphazardly present in the basement membrane zone of the aggregated tumor cells and within the cytoplasm of some cells. This finding indicates that metastatic malignant epithelial cells may produce bullous pemphigoid antigen in the alternative environment, especially if situated in the skin.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

A 90-year-old white woman developed a low-grade cutaneous angiosarcoma arising on a chronically lymphedematous extremity 15 years after a radical mastectomy for breast carcinoma. This neoplasm had the clinical appearance of lymphangioma circumscriptum and was characterized by an unusually benign course with a 3-year follow-up.

ISSN:0193-1091    

出版商:OVID    

年代:1988

数据来源: OVID