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1. |
LE or Not LE-That Is the QuestionAn Unsuccessful Attempt to Separate Lymphocytic Infiltration From the Spectrum of Discoid Lupus Erythematosus |
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The American Journal of Dermatopathology,
Volume 20,
Issue 3,
1998,
Page 225-232
Wolfgang Weyers,
Matthias Bonczkowitz,
Imke Weyers,
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摘要:
Lymphocytic infiltration of the skin (LIS) has been claimed to be a distinct entity that differs from discoid lupus erythematosus (DLE) by the lack of epidermal changes, negative immunofluorescence tests, and differences in the composition of the inflammatory cell infiltrate. In studies that sought to distinguish both conditions, however, cases of established lupus erythematosus without epidermal involvement have not been considered. We studied 72 patients with the clinical and histopathologic diagnosis of either LIS or DLE in regard to the same clinical, histopathologic, immunofluorescence, and immunohistochemical criteria. No significant differences were noted between cases with and without epidermal involvement on the one hand and between cases with and without immunofluorescence or clinical findings suggestive of lupus erythematosus on the other. Based on our findings, it is not possible to separate LIS from the spectrum of DLE.
ISSN:0193-1091
出版商:OVID
年代:1998
数据来源: OVID
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2. |
Apoptosis in the Pathogenesis of Cutaneous Lupus Erythematosus |
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The American Journal of Dermatopathology,
Volume 20,
Issue 3,
1998,
Page 233-241
Jin Chung,
Oh Kwon,
Hee Eun,
Jai Youn,
Yeong Song,
Joong Kim,
Kwang Cho,
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摘要:
Defective regulation of apoptosis may play a role in the development of autoimmune diseases such as systemic lupus erythematosus, in which the skin is a prominent target. To our knowledge, however, the nature of epidermal changes in cutaneous lupus erythematosus (LE) has not previously been investigated. We investigated the involvement of apoptosis in cutaneous LE. A total of 44 lesional skin samples from patients with cutaneous LE, 44 skin samples from patients with scleroderma, five skin specimens from patients suffering from dermatomyositis, and 13 normal skin samples were stained immunohistochemically with monoclonal antibodies to Ki-67, p53 (DO-7), and bcl-2. The lesional skin from cutaneous LE, except LE profundus, showed a marked increase in Ki-67- and p53-positive keratinocytes, which were predominantly located in the basal layer of the epidermis and follicle, and a drastic reduction in the number of bcl-2-positive cells localized in the basal cell compartment. With TdT-mediated dUTP-biotin nick end-labeling staining, we demonstrated that extensive apoptosis occurred in almost the whole epidermis of cutaneous LE, except in cases of LE profundus. This abnormal expression of Ki-67, p53, and bcl-2 and the occurrence of apoptosis in the epidermis was also observed in epidermis from patients with dermatomyositis, but not in that from patients with scleroderma.
ISSN:0193-1091
出版商:OVID
年代:1998
数据来源: OVID
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3. |
Membranocystic Lesions in a Patient With Cytophagic Histiocytic Panniculitis Associated With Subcutaneous T-cell Lymphoma |
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The American Journal of Dermatopathology,
Volume 20,
Issue 3,
1998,
Page 276-280
Naoki Ohtake,
Shoko Shimada,
Shimako Mizoguchi,
Mitsuru Setoyama,
Tamotsu Kanzaki,
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摘要:
A 51-year-old Japanese woman had erythematous, tender subcutaneous nodules on her lower legs and buttocks, as well as fever, pancytopenia, and liver dysfunction. Histopathologic examination of the nodules showed subcutaneous T-cell lymphoma with cytophagocytosis and membranocystic lesions. Our patient was unique in having the combination of cytophagic histiocytic panniculitis due to subcutaneous T-cell lymphoma and membranocystic lesions.
ISSN:0193-1091
出版商:OVID
年代:1998
数据来源: OVID
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