ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Sixteen skin biopsy specimens from early eruptive, evolving papules and well-developed plaques were obtained from eight patients with established atopic dermatitis. We found that the chronological and histopathological sequence begins with a perivascular interstitial spongiotic dermatitis, evolves into a psoriasiform microvesicular spongiotic dermatitis, which is sometimes locally lichenoid, and eventually concludes as a psoriasiform dermatitis. Thus, atopic dermatitis has characteristic and diagnostic histopathologic findings. These are portrayed and contrasted to what has been previously reported.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Eeerine epithelioma is an exceedingly rare cutaneous tumor thought to represent the malignant counterpart of the eccrine dermal syringoma. To date, only 10 accepted cases appear to have been reported. Two additional cases are described here and the literature is reviewed. The first case showed the typical histologic features of eccrine epithelioma. The second case showed extensive clear cell change (due to glycogen accumulation), reminiscent of the clear cell syringoma; conspicuous pseudo-apocrine metaplasia was also noted. The latter appearance has not been previously described in eccrine epithelioma.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

10 fmol ER/mg protein) at 11 fmol. The melanomas in 97% of the cases we studied were ER negative by two or three different assays. Eow-level estrogen binding of MM tissues may be the result of interactions other than with Type 1 true ER. The low frequency of ER positivity of malignant melanomas appears to preclude the clinical use of ER status as an indicator for response to hormonal manipulation in patients with malignant melanoma.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Chemical warfare agents have been used in recent conflicts. We present a review of the clinical manifestations of mustard gas casualties and we studied the histological presentation of cutaneous lesions. Four groups of alterations were recognized, namely (a) alterations of kerati-nocytes. (b) epidermal hyperplasia with or without atypia. (c) alterations of the melanocytic system, and (d) structural changes of the dermis.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Oral hairy leukoplakia (HL) was studied in 32 patients infected with the human immunodeficiency virus (HIV). Features most often found were parakeratosis of variable thickness, aeanthosis, little or absent submueosal chronic inflammatory cell infiltrate, association with candidiasis in 71.8%, and intranuclear herpetic type inclusions in keratinocytes, associated with ballooned or ground-glass cytoplasm. The last feature was found in all biopsies and was most striking at the top of the stratum spinosum, just beneath the parakeratotic surface.We consider that intranuclear inclusions are the histologic hallmark of HL, which, together with other features described, make it possible to diagnose HI, specifically by light microscopic examination. Ultrastructural studies were carried out in 20 cases. Viral particles of the human herpesvirus group were detected in 17 cases. Particles of papillomavirus (HPV) were not found in any of the specimens. Immunohistoehemical studies were made in 26 cases using a rabbit antiserum to papillomavirus. Nuclear positivity was observed in 25 cases. Despite such apparently contradictory results, we think that a cross reaction may exist between the antiserum used against HPV and some antigens of the Epstein-Barr virus (EBV).

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Numerous nodular xanthomatous lesions arose, gradually increasing in number on the back, chest, lips, tongue, and exposed “V” area of the chest on a 78-year-old man. Painful oral nodules and hoarseness developed subsequently. Histologic examination of the skin revealed a suppurative and granulomatous inflammation with an accumulation of acute polymorphonuclear neutrophils, nuclear dust, and xanthomatous histiocytes. Giant cells were rare and cholesterol clefts were absent. Biopsy of the oral mucosa and the larynx showed a similar process. Direct immunofluorescenee was positive for vascular immune reactants at the basement membrane and fibrin in between collagen bundles. The patient had a serum IgA level of 432 mg/dl (normal level, up to 380), with normal Igü and IgM serum concentrations. A Raji cell assay was 240 $mUg/AHGEQ/ml (normal < 5). CH-50 was decreased and C2, C4, and C3 were within normal limits. The dermatopathology was initially thought to be consistent with erythema elevatum diutinum, and the patient was treated with dapsone and prednisone, with a marginal response. There were no dermatopathologic findings of vasculitis. On review, the patient's dermatopathology was more consistent with necrobiotic xanthogranuloma (NXG). To our knowledge, this is the first report of an association of NXG with an IgA gammopathy and the second reported case of extracutaneous involvement with NXG.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

We report a case of subcutaneous splenosis in the abdominal wall of a 38-year-old woman who had suffered splenic trauma 30 years earlier. A review of the literature shows only five previous cases with subcutaneous involvement.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

A carcinoma arising in the skin of the lip metastasized to the lymph nodes in the neck of a 53-year-old white man. Electron microscopy of the initial excisional biopsy specimen revealed that the tumor cells contained dense-cored vesicles (100 nm in diameter) in their cytoplasm and were joined by simple junctions. Cells from the nodal metastases were found to be immunoreactive for neuron-specific enolase, keratin intermediate filaments, and chromogranin A, but not for neurofilaments. The tumor was thus classified as a neuroendocrine skin carcinoma. In addition, its metastatie cells shared immunoreactive and ultrastructural characteristics of Merkel cells, which are situated in the basal epidermis of normal skin. Primary cultures from a nodal metastasis were established and characterized. The cells attached and proliferated on culture flask surfaces. The population-doubling time was 2 days. This is the first report where cells from a neuroendocrine skin carcinoma have been demonstrated to retain their characteristic ultrastructure in an in vitro environment (10 days). Studies of cells cultured from neuroendocrine skin carcinomas may prove useful in understanding the pathobiology of this disease and help define the in vitro growth requirements of nontransformed Merkel cells as well.

ISSN:0193-1091    

出版商:OVID    

年代:1990

数据来源: OVID